| | | |
| March 26, 2022 | L | Minnesota United FC 2 1 at North Texas SC 3 | Final |
| April 3, 2022 | L | Sporting Kansas City II 2 at Minnesota United FC 2 0 | Final |
| April 8, 2022 | W | Minnesota United FC 2 3 at Real Monarchs 2 | Final |
| April 17, 2022 | W | Colorado Rapids 2 0 at Minnesota United FC 2 4 | Final |
| April 24, 2022 | W | Minnesota United FC 2 4 at St. Louis City SC 2 0 | Final |
| May 8, 2022 | T | Minnesota United FC 2 0 at Chicago Fire FC II 0 | Final (PK 7-6) |
| May 14, 2022 | T | Houston Dynamo 2 1 at Minnesota United FC 2 1 | Final (PK 4-5) |
| May 21, 2022 | T | Minnesota United FC 2 2 at Vancouver Whitecaps FC 2 2 | Final (PK 3-1) |
| May 29, 2022 | | Colorado Rapids 2 at Minnesota United FC 2 | 2:00 p.m. |
| June 4, 2022 | | Minnesota United FC 2 at Sporting Kansas City II | 8:00 p.m. |
| June 8, 2022 | | Minnesota United FC 2 at Earthquakes II | 10:00 p.m. |
| June 26, 2022 | | Minnesota United FC 2 at North Texas SC | 8:30 p.m. |
| July 2, 2022 | | Vancouver Whitecaps FC 2 at Minnesota United FC 2 | 8:00 p.m. |
| July 10, 2022 | | St. Louis City SC 2 at Minnesota United FC 2 | 9:00 p.m. |
| July 17, 2022 | | Minnesota United FC 2 at Tacoma Defiance | 10:00 p.m. |
| July 24, 2022 | | Minnesota United FC 2 at Houston Dynamo 2 | 8:00 p.m. |
| July 31, 2022 | | Portland Timbers 2 at Minnesota United FC 2 | 6:00 p.m. |
| August 6, 2022 | | Minnesota United FC 2 at Colorado Rapids 2 | 12:00 a.m. |
| August 15, 2022 | | Tacoma Defiance at Minnesota United FC 2 | 8:00 p.m. |
| August 21, 2022 | | Real Monarchs at Minnesota United FC 2 | 9:00 p.m. |
| August 27, 2022 | | Houston Dynamo 2 at Minnesota United FC 2 | 7:00 p.m. |
| September 3, 2022 | | North Texas SC at Minnesota United FC 2 | 7:00 p.m. |
| September 11, 2022 | | Minnesota United FC 2 at Portland Timbers 2 | 5:00 p.m. |
| September 18, 2022 | | Earthquakes II at Minnesota United FC 2 | 7:00 p.m. |
Minnesota United FC 2 Schedule
