Michigan Panthers Schedule
All times Eastern
Complete Schedule
| March 30, 2025 | W | Michigan Panthers 26 at Memphis Showboats 12 | Final |
| April 4, 2025 | L | Birmingham Stallions 21 at Michigan Panthers 12 | Final |
| April 13, 2025 | W | San Antonio Brahmas 23 at Michigan Panthers 26 | Final |
| April 18, 2025 | W | Memphis Showboats 9 at Michigan Panthers 27 | Final |
| April 26, 2025 | L | Michigan Panthers 27 at St. Louis Battlehawks 32 | Final |
| May 4, 2025 | W | DC Defenders 14 at Michigan Panthers 38 | Final |
| May 10, 2025 | W | Michigan Panthers 25 at Arlington Renegades 24 | Final |
| May 17, 2025 | W | Michigan Panthers 30 at Houston Roughnecks 18 | Final |
| May 24, 2025 | L | Michigan Panthers 22 at Birmingham Stallions 26 | Final |
| May 31, 2025 | L | Houston Roughnecks 19 at Michigan Panthers 12 | Final |
| June 8, 2025 | W | Michigan Panthers 44 at Birmingham Stallions 29 (Playoff) | Final |
| June 14, 2025 | L | DC Defenders 58 at Michigan Panthers 34 (Championship; St. Louis) | Final |
