| | | |
| April 21, 2022 | L | Kentucky Wild Health Genomes 5 at High Point Rockers 10 | Final |
| April 22, 2022 | W | Kentucky Wild Health Genomes 2 at High Point Rockers 1 | Final (10) |
| April 23, 2022 | W | Kentucky Wild Health Genomes 3 at High Point Rockers 1 | Final |
| April 24, 2022 | L | Kentucky Wild Health Genomes 2 at High Point Rockers 7 | Final |
| April 26, 2022 | L | Kentucky Wild Health Genomes 1 at Gastonia Honey Hunters 12 | Final |
| April 27, 2022 | L | Kentucky Wild Health Genomes 4 at Gastonia Honey Hunters 17 | Final |
| April 28, 2022 | L | Kentucky Wild Health Genomes 4 at Gastonia Honey Hunters 6 | Final |
| April 29, 2022 | L | Kentucky Wild Health Genomes 9 at Southern Maryland Blue Crabs 14 | Final |
| April 30, 2022 | L | Kentucky Wild Health Genomes 2 at Southern Maryland Blue Crabs 16 | Final |
| May 1, 2022 | L | Kentucky Wild Health Genomes 6 at Southern Maryland Blue Crabs 8 | Final |
| May 3, 2022 | L | Charleston Dirty Birds 9 at Kentucky Wild Health Genomes 6 | Final (7) |
| May 4, 2022 | W | Charleston Dirty Birds 1 at Kentucky Wild Health Genomes 7 | Final |
| May 5, 2022 | W | Charleston Dirty Birds 7 at Kentucky Wild Health Genomes 8 | Final (10) |
| May 6, 2022 | L | Southern Maryland Blue Crabs 8 at Kentucky Wild Health Genomes 2 | Final |
| May 7, 2022 | W | Southern Maryland Blue Crabs 2 at Kentucky Wild Health Genomes 7 | Final |
| May 8, 2022 | L | Southern Maryland Blue Crabs 9 at Kentucky Wild Health Genomes 7 | Final |
| May 10, 2022 | | Kentucky Wild Health Genomes at Lexington Legends | Susp. |
| May 11, 2022 | | Kentucky Wild Health Genomes at Lexington Legends (Game 2) | Ppd. |
| May 11, 2022 | | Kentucky Wild Health Genomes at Lexington Legends (Game 1) | Susp. |
| May 12, 2022 | W | Kentucky Wild Health Genomes 7 at Lexington Legends 1 (Game 1) | Final (7) |
| May 12, 2022 | W | Kentucky Wild Health Genomes 5 at Lexington Legends 0 (Game 2) | Final (7) |
| May 13, 2022 | W | Kentucky Wild Health Genomes 7 at Lexington Legends 2 (Game 1) | Final |
| May 13, 2022 | L | Kentucky Wild Health Genomes 2 at Lexington Legends 3 (Game 2) | Final (7) |
| May 14, 2022 | W | Kentucky Wild Health Genomes 9 at Lexington Legends 3 | Final |
| May 15, 2022 | L | Kentucky Wild Health Genomes 1 at Lexington Legends 10 | Final |
| May 17, 2022 | L | Charleston Dirty Birds 16 at Kentucky Wild Health Genomes 2 | Final |
| May 18, 2022 | W | Charleston Dirty Birds 0 at Kentucky Wild Health Genomes 2 | Final |
| May 19, 2022 | W | Charleston Dirty Birds 9 at Kentucky Wild Health Genomes 10 | Final (11) |
| May 20, 2022 | L | Lancaster Stormers 16 at Kentucky Wild Health Genomes 10 | Final |
| May 21, 2022 | L | Lancaster Stormers 13 at Kentucky Wild Health Genomes 3 | Final |
| May 22, 2022 | W | Lancaster Stormers 0 at Kentucky Wild Health Genomes 5 | Final |
| May 24, 2022 | | Kentucky Wild Health Genomes at Lexington Legends | Ppd. |
| May 25, 2022 | | Kentucky Wild Health Genomes at Lexington Legends | Ppd. |
| May 26, 2022 | | Kentucky Wild Health Genomes at Lexington Legends | Ppd. |
| May 30, 2022 | W | Lexington Legends 5 at Kentucky Wild Health Genomes 9 (Game 1) | Final (7) |
| May 30, 2022 | W | Lexington Legends 3 at Kentucky Wild Health Genomes 9 (Game 2) | Final (7) |
| May 31, 2022 | L | Lexington Legends 5 at Kentucky Wild Health Genomes 1 (Game 1) | Final (7) |
| May 31, 2022 | W | Lexington Legends 5 at Kentucky Wild Health Genomes 12 (Game 2) | Final (7) |
| June 1, 2022 | | Lexington Legends at Kentucky Wild Health Genomes | Susp. |
| June 2, 2022 | W | Lexington Legends 9 at Kentucky Wild Health Genomes 11 (Game 1) | Final |
| June 2, 2022 | W | Lexington Legends 1 at Kentucky Wild Health Genomes 9 (Game 2) | Final |
| June 3, 2022 | L | Kentucky Wild Health Genomes 4 at York Revolution 10 | Final |
| June 4, 2022 | L | Kentucky Wild Health Genomes 11 at York Revolution 14 | Final |
| June 5, 2022 | W | Kentucky Wild Health Genomes 8 at York Revolution 6 | Final |
| June 7, 2022 | W | High Point Rockers 3 at Kentucky Wild Health Genomes 11 | Final |
| June 8, 2022 | W | High Point Rockers 6 at Kentucky Wild Health Genomes 9 | Final |
| June 9, 2022 | W | High Point Rockers 2 at Kentucky Wild Health Genomes 8 | Final |
| June 10, 2022 | L | York Revolution 8 at Kentucky Wild Health Genomes 3 | Final |
| June 11, 2022 | W | York Revolution 4 at Kentucky Wild Health Genomes 5 | Final |
| June 12, 2022 | L | York Revolution 10 at Kentucky Wild Health Genomes 2 | Final |
| June 14, 2022 | L | Kentucky Wild Health Genomes 4 at Lancaster Stormers 9 | Final |
| June 15, 2022 | W | Kentucky Wild Health Genomes 7 at Lancaster Stormers 2 | Final |
| June 16, 2022 | W | Kentucky Wild Health Genomes 2 at Lancaster Stormers 1 | Final |
| June 17, 2022 | L | Kentucky Wild Health Genomes 0 at Long Island Ducks 4 | Final |
| June 18, 2022 | L | Kentucky Wild Health Genomes 0 at Long Island Ducks 10 | Final |
| June 19, 2022 | L | Kentucky Wild Health Genomes 1 at Long Island Ducks 7 | Final |
| June 21, 2022 | W | Lexington Legends 4 at Kentucky Wild Health Genomes 6 (Game 1) | Final (7) |
| June 21, 2022 | L | Lexington Legends 5 at Kentucky Wild Health Genomes 2 (Game 2) | Final (7) |
| June 22, 2022 | L | Lexington Legends 8 at Kentucky Wild Health Genomes 6 | Final |
| June 23, 2022 | L | Lexington Legends 5 at Kentucky Wild Health Genomes 3 (Game 1) | Final (7) |
| June 23, 2022 | W | Kentucky Wild Health Genomes 5 at Lexington Legends 4 (Game 2) | Final (7) |
| June 24, 2022 | W | Charleston Dirty Birds 3 at Kentucky Wild Health Genomes 4 | Final |
| June 25, 2022 | W | Charleston Dirty Birds 8 at Kentucky Wild Health Genomes 11 | Final |
| June 26, 2022 | L | Charleston Dirty Birds 7 at Kentucky Wild Health Genomes 6 | Final |
| June 28, 2022 | L | Kentucky Wild Health Genomes 0 at Gastonia Honey Hunters 4 | Final |
| June 29, 2022 | W | Kentucky Wild Health Genomes 11 at Gastonia Honey Hunters 2 | Final |
| June 30, 2022 | W | Kentucky Wild Health Genomes 7 at Gastonia Honey Hunters 6 | Final |
| July 1, 2022 | L | Kentucky Wild Health Genomes 1 at Charleston Dirty Birds 2 | Final (11) |
| July 2, 2022 | W | Kentucky Wild Health Genomes 7 at Charleston Dirty Birds 5 | Final (10) |
| July 3, 2022 | W | Kentucky Wild Health Genomes 7 at Charleston Dirty Birds 6 | Final |
| July 4, 2022 | W | Lexington Legends 1 at Kentucky Wild Health Genomes 2 (Game 1) | Final (7) |
| July 4, 2022 | W | Lexington Legends 5 at Kentucky Wild Health Genomes 6 (Game 2) | Final (7) |
| July 5, 2022 | W | Kentucky Wild Health Genomes 11 at Lexington Legends 8 | Final |
| July 6, 2022 | W | Kentucky Wild Health Genomes 8 at Lexington Legends 2 | Final |
| July 7, 2022 | L | Kentucky Wild Health Genomes 1 at Lexington Legends 7 | Final |
| July 8, 2022 | L | Kentucky Wild Health Genomes 5 at Lancaster Stormers 18 | Final |
| July 9, 2022 | L | Kentucky Wild Health Genomes 1 at Lancaster Stormers 5 | Final |
| July 10, 2022 | L | Kentucky Wild Health Genomes 4 at Lancaster Stormers 10 | Final |
| July 12, 2022 | L | Gastonia Honey Hunters 8 at Kentucky Wild Health Genomes 6 | Final |
| July 13, 2022 | L | Gastonia Honey Hunters 6 at Kentucky Wild Health Genomes 2 | Final |
| July 14, 2022 | L | Gastonia Honey Hunters 4 at Kentucky Wild Health Genomes 1 | Final |
| July 15, 2022 | W | Long Island Ducks 0 at Kentucky Wild Health Genomes 5 | Final |
| July 16, 2022 | W | Long Island Ducks 0 at Kentucky Wild Health Genomes 3 | Final |
| July 17, 2022 | W | Long Island Ducks 4 at Kentucky Wild Health Genomes 9 | Final |
| July 19, 2022 | W | Kentucky Wild Health Genomes 3 at Staten Island FerryHawks 0 | Final |
| July 20, 2022 | W | Kentucky Wild Health Genomes 5 at Staten Island FerryHawks 2 | Final |
| July 21, 2022 | W | Kentucky Wild Health Genomes 7 at Staten Island FerryHawks 4 | Final |
| July 22, 2022 | L | Kentucky Wild Health Genomes 3 at Charleston Dirty Birds 4 | Final |
| July 23, 2022 | L | Kentucky Wild Health Genomes 2 at Charleston Dirty Birds 7 | Final |
| July 24, 2022 | L | Kentucky Wild Health Genomes 2 at Charleston Dirty Birds 13 | Final |
| July 26, 2022 | W | High Point Rockers 4 at Kentucky Wild Health Genomes 10 | Final |
| July 27, 2022 | W | High Point Rockers 7 at Kentucky Wild Health Genomes 8 | Final |
| July 28, 2022 | L | High Point Rockers 9 at Kentucky Wild Health Genomes 7 | Final |
| July 29, 2022 | W | Long Island Ducks 1 at Kentucky Wild Health Genomes 11 | Final |
| July 30, 2022 | L | Long Island Ducks 3 at Kentucky Wild Health Genomes 1 | Final |
| July 31, 2022 | W | Long Island Ducks 6 at Kentucky Wild Health Genomes 9 | Final |
| August 2, 2022 | W | Kentucky Wild Health Genomes 10 at High Point Rockers 9 | Final |
| August 3, 2022 | L | Kentucky Wild Health Genomes 4 at High Point Rockers 9 | Final |
| August 4, 2022 | W | Kentucky Wild Health Genomes 6 at High Point Rockers 2 | Final |
| August 5, 2022 | W | Kentucky Wild Health Genomes 13 at Lexington Legends 3 | Final |
| August 6, 2022 | L | Kentucky Wild Health Genomes 2 at Lexington Legends 8 | Final |
| August 7, 2022 | W | Kentucky Wild Health Genomes 18 at Lexington Legends 1 | Final (7) |
| August 9, 2022 | W | Kentucky Wild Health Genomes 5 at Lexington Legends 2 (Game 1) | Final (7) |
| August 9, 2022 | | Lexington Legends at Kentucky Wild Health Genomes (Game 2) | Susp. |
| August 10, 2022 | W | Lexington Legends 3 at Kentucky Wild Health Genomes 4 (Game 1) | Final (8) |
| August 10, 2022 | | Lexington Legends at Kentucky Wild Health Genomes (Game 2) | Ppd. |
| August 11, 2022 | L | Lexington Legends 10 at Kentucky Wild Health Genomes 2 | Final |
| August 12, 2022 | W | Kentucky Wild Health Genomes 12 at York Revolution 2 | Final |
| August 13, 2022 | L | Kentucky Wild Health Genomes 3 at York Revolution 5 | Final |
| August 14, 2022 | W | Kentucky Wild Health Genomes 13 at York Revolution 2 | Final |
| August 16, 2022 | L | Kentucky Wild Health Genomes 6 at Lexington Legends 7 | Final (10) |
| August 17, 2022 | L | Kentucky Wild Health Genomes 3 at Lexington Legends 4 | Final (10) |
| August 18, 2022 | L | Kentucky Wild Health Genomes 7 at Lexington Legends 8 | Final |
| August 19, 2022 | L | Kentucky Wild Health Genomes 7 at Southern Maryland Blue Crabs 8 | Final |
| August 20, 2022 | W | Kentucky Wild Health Genomes 6 at Southern Maryland Blue Crabs 4 | Final |
| August 21, 2022 | W | Kentucky Wild Health Genomes 2 at Southern Maryland Blue Crabs 0 | Final |
| August 23, 2022 | L | Staten Island FerryHawks 9 at Kentucky Wild Health Genomes 7 | Final |
| August 24, 2022 | W | Staten Island FerryHawks 0 at Kentucky Wild Health Genomes 4 | Final |
| August 25, 2022 | W | Staten Island FerryHawks 11 at Kentucky Wild Health Genomes 13 | Final |
| August 26, 2022 | W | Lexington Legends 1 at Kentucky Wild Health Genomes 6 | Final |
| August 27, 2022 | | Lexington Legends at Kentucky Wild Health Genomes (Game 1) | Ppd. |
| August 27, 2022 | | Lexington Legends at Kentucky Wild Health Genomes (Game 2) | Ppd. |
| August 28, 2022 | L | Lexington Legends 9 at Kentucky Wild Health Genomes 6 (Game 1) | Final |
| August 28, 2022 | L | Lexington Legends 11 at Kentucky Wild Health Genomes 8 (Game 2) | Final (7) |
| August 30, 2022 | L | Kentucky Wild Health Genomes 1 at Lexington Legends 5 | Final |
| August 31, 2022 | L | Kentucky Wild Health Genomes 16 at Lexington Legends 17 | Final (11) |
| September 1, 2022 | W | Kentucky Wild Health Genomes 10 at Lexington Legends 3 | Final |
| September 2, 2022 | W | Kentucky Wild Health Genomes 3 at Gastonia Honey Hunters 2 | Final |
| September 3, 2022 | L | Kentucky Wild Health Genomes 3 at Gastonia Honey Hunters 5 | Final |
| September 4, 2022 | W | Kentucky Wild Health Genomes 5 at Gastonia Honey Hunters 4 | Final |
| September 6, 2022 | L | Gastonia Honey Hunters 5 at Kentucky Wild Health Genomes 2 | Final |
| September 7, 2022 | L | Gastonia Honey Hunters 6 at Kentucky Wild Health Genomes 3 | Final |
| September 8, 2022 | L | Gastonia Honey Hunters 9 at Kentucky Wild Health Genomes 4 | Final |
| September 9, 2022 | L | High Point Rockers 12 at Kentucky Wild Health Genomes 3 | Final |
| September 10, 2022 | L | High Point Rockers 14 at Kentucky Wild Health Genomes 2 | Final |
| September 11, 2022 | W | High Point Rockers 7 at Kentucky Wild Health Genomes 9 | Final |
| September 13, 2022 | L | Kentucky Wild Health Genomes 1 at Staten Island FerryHawks 4 | Final |
| September 14, 2022 | W | Kentucky Wild Health Genomes 16 at Staten Island FerryHawks 10 | Final |
| September 15, 2022 | W | Kentucky Wild Health Genomes 12 at Staten Island FerryHawks 4 | Final |
| September 16, 2022 | W | Lexington Legends 5 at Kentucky Wild Health Genomes 7 | Final (7) |
| September 17, 2022 | W | Lexington Legends 6 at Kentucky Wild Health Genomes 8 (Game 1) | Final (7) |
| September 17, 2022 | L | Lexington Legends 12 at Kentucky Wild Health Genomes 9 (Game 2) | Final (7) |
| September 18, 2022 | L | Lexington Legends 20 at Kentucky Wild Health Genomes 9 | Final (7) |
Kentucky Wild Health Genomes Schedule
