| | | |
| March 8, 2025 | T | Colorado Springs Switchbacks FC 2 at El Paso Locomotive FC 2 | Final |
| March 15, 2025 | T | Phoenix Rising FC 4 at El Paso Locomotive FC 4 | Final |
| March 22, 2025 | L | El Paso Locomotive FC 0 at New Mexico United 1 | Final |
| March 29, 2025 | W | El Paso Locomotive FC 2 at Hartford Athletic 1 | Final |
| April 5, 2025 | W | Lexington Sporting Club 1 at El Paso Locomotive FC 2 | Final |
| April 13, 2025 | L | El Paso Locomotive FC 1 at Birmingham Legion FC 3 | Final |
| April 19, 2025 | T | El Paso Locomotive FC 1 at Colorado Springs Switchbacks FC 1 | Final |
| April 26, 2025 | T | El Paso Locomotive FC 0 at Texoma FC 0 (Jagermeister Cup) | Final |
| May 3, 2025 | | New Mexico United at El Paso Locomotive FC | 9:00 p.m. |
| May 10, 2025 | | El Paso Locomotive FC at FC Tulsa | 8:00 p.m. |
| May 16, 2025 | | Indy Eleven at El Paso Locomotive FC | 9:00 p.m. |
| May 24, 2025 | | El Paso Locomotive FC at Las Vegas Lights FC | 10:30 p.m. |
| May 31, 2025 | | Colorado Springs Switchbacks FC at El Paso Locomotive FC | 9:00 p.m. |
| June 7, 2025 | | El Paso Locomotive FC at Oakland Roots | 10:00 p.m. |
| June 14, 2025 | | Orange County SC at El Paso Locomotive FC | 9:00 p.m. |
| June 21, 2025 | | El Paso Locomotive FC at Monterey Bay FC | 10:00 p.m. |
| July 4, 2025 | | San Antonio FC at El Paso Locomotive FC | 9:00 p.m. |
| July 12, 2025 | | El Paso Locomotive FC at Sacramento Republic FC | 11:00 p.m. |
| July 19, 2025 | | Phoenix Rising FC at El Paso Locomotive FC | 9:00 p.m. |
| July 26, 2025 | | El Paso Locomotive FC at Union Omaha | 8:00 p.m. |
| August 2, 2025 | | Las Vegas Lights FC at El Paso Locomotive FC | 9:00 p.m. |
| August 9, 2025 | | El Paso Locomotive FC at Miami FC | 7:00 p.m. |
| August 16, 2025 | | Monterey Bay FC at El Paso Locomotive FC | 9:00 p.m. |
| August 23, 2025 | | Sacramento Republic FC at El Paso Locomotive FC | 9:00 p.m. |
| August 30, 2025 | | El Paso Locomotive FC at Phoenix Rising FC | 10:30 p.m. |
| September 6, 2025 | | Loudoun United FC at El Paso Locomotive FC | 9:00 p.m. |
| September 12, 2025 | | El Paso Locomotive FC at North Carolina FC | 7:00 p.m. |
| September 20, 2025 | | Charleston Battery at El Paso Locomotive FC | 9:00 p.m. |
| September 27, 2025 | | Rhode Island FC at El Paso Locomotive FC | 9:00 p.m. |
| October 1, 2025 | | Oakland Roots at El Paso Locomotive FC | 2:00 p.m. |
| October 4, 2025 | | El Paso Locomotive FC at Orange County SC | 10:00 p.m. |
| October 11, 2025 | | El Paso Locomotive FC at Lexington Sporting Club | 7:00 p.m. |
| October 18, 2025 | | FC Tulsa at El Paso Locomotive FC | 9:00 p.m. |
| October 25, 2025 | | El Paso Locomotive FC at San Antonio FC | 8:30 p.m. |
El Paso Locomotive FC Schedule
