| | | |
| March 7, 2025 | L | Colorado Rapids 2 2 at Austin FC II 4 | Final |
| March 23, 2025 | T | Colorado Rapids 2 2 at Real Monarchs 2 | Final (PK 6-7) |
| April 6, 2025 | W | Colorado Rapids 2 1 at St. Louis City SC 2 0 | Final |
| April 13, 2025 | W | Colorado Rapids 2 2 at Portland Timbers 2 1 | Final |
| April 20, 2025 | W | Colorado Rapids 2 3 at North Texas SC 2 | Final |
| April 24, 2025 | L | Minnesota United FC 2 2 at Colorado Rapids 2 0 | Final |
| April 27, 2025 | W | Sporting Kansas City II 0 at Colorado Rapids 2 3 | Final |
| May 4, 2025 | L | Colorado Rapids 2 2 at LAFC2 3 | Final |
| May 9, 2025 | | Colorado Rapids 2 at Houston Dynamo 2 | 7:00 p.m. |
| May 18, 2025 | | Real Monarchs at Colorado Rapids 2 | 4:30 p.m. |
| May 25, 2025 | | The Town FC at Colorado Rapids 2 | 8:00 p.m. |
| June 1, 2025 | | Colorado Rapids 2 at Sporting Kansas City II | 1:00 p.m. |
| June 8, 2025 | | Austin FC II at Colorado Rapids 2 | 8:00 p.m. |
| June 15, 2025 | | St. Louis City SC 2 at Colorado Rapids 2 | 8:00 p.m. |
| June 18, 2025 | | North Texas SC at Colorado Rapids 2 | 8:00 p.m. |
| June 28, 2025 | | Colorado Rapids 2 at Minnesota United FC 2 | 8:00 p.m. |
| July 6, 2025 | | Houston Dynamo 2 at Colorado Rapids 2 | 8:00 p.m. |
| July 13, 2025 | | Vancouver Whitecaps FC 2 at Colorado Rapids 2 | 8:00 p.m. |
| July 20, 2025 | | Tacoma Defiance at Colorado Rapids 2 | 8:00 p.m. |
| August 2, 2025 | | Colorado Rapids 2 at North Texas SC | 8:45 p.m. |
| August 10, 2025 | | Colorado Rapids 2 at St. Louis City SC 2 | 7:00 p.m. |
| August 15, 2025 | | Austin FC II at Colorado Rapids 2 | 8:00 p.m. |
| August 20, 2025 | | Portland Timbers 2 at Colorado Rapids 2 | 8:00 p.m. |
| August 31, 2025 | | Colorado Rapids 2 at Sporting Kansas City II | 1:00 p.m. |
| September 14, 2025 | | Houston Dynamo 2 at Colorado Rapids 2 | 8:00 p.m. |
| September 21, 2025 | | Colorado Rapids 2 at Tacoma Defiance | 10:00 p.m. |
| September 27, 2025 | | Minnesota United FC 2 at Colorado Rapids 2 | 4:30 p.m. |
| October 5, 2025 | | Colorado Rapids 2 at Ventura County FC | 4:00 p.m. |
Colorado Rapids 2 Schedule
