| | | |
| February 15, 2025 | L | Chicago Hounds 25 at Houston SaberCats 22 | Final |
| February 23, 2025 | L | Houston SaberCats 12 at Rugby FC Los Angeles 28 | Final |
| March 1, 2025 | W | Seattle Seawolves 21 at Houston SaberCats 24 | Final |
| March 8, 2025 | W | Houston SaberCats 37 at Utah Warriors 17 | Final |
| March 22, 2025 | W | Houston SaberCats 46 at Anthem Rugby Carolina 45 | Final |
| March 29, 2025 | W | San Diego Legion 14 at Houston SaberCats 34 | Final |
| April 5, 2025 | L | Rugby FC Los Angeles 24 at Houston SaberCats 22 | Final |
| April 12, 2025 | L | Houston SaberCats 22 at Miami Sharks 31 | Final |
| April 19, 2025 | W | NOLA Gold 15 at Houston SaberCats 17 | Final |
| April 26, 2025 | W | Old Glory DC 27 at Houston SaberCats 48 | Final |
| May 4, 2025 | L | Houston SaberCats 17 at New England Free Jacks 36 | Final |
| May 10, 2025 | W | Houston SaberCats 37 at San Diego Legion 20 | Final |
| May 17, 2025 | W | Utah Warriors 19 at Houston SaberCats 40 | Final |
| May 23, 2025 | L | Houston SaberCats 9 at Seattle Seawolves 14 | Final |
| June 4, 2025 | L | Houston SaberCats 12 at Chicago Hounds 15 | Final |
| June 8, 2025 | W | Anthem Rugby Carolina 14 at Houston SaberCats 26 | Final |
| June 15, 2025 | | Rugby FC Los Angeles at Houston SaberCats (Playoff) | 8:30 p.m. |
Houston SaberCats Schedule
