| | | |
| March 15, 2025 | L | Portland Thorns FC 1 at Kansas City Current 3 | Final |
| March 21, 2025 | T | Angel City FC 1 at Portland Thorns FC 1 | Final |
| March 29, 2025 | T | North Carolina Courage 0 at Portland Thorns FC 0 | Final |
| April 11, 2025 | W | Portland Thorns FC 1 at Utah Royals FC 0 | Final |
| April 18, 2025 | L | Portland Thorns FC 0 at Seattle Reign FC 1 | Final |
| April 22, 2025 | W | NJ/NY Gotham FC 1 at Portland Thorns FC 4 | Final |
| April 27, 2025 | T | Racing Louisville FC 3 at Portland Thorns FC 3 | Final |
| May 3, 2025 | W | Orlando Pride 0 at Portland Thorns FC 1 | Final |
| May 10, 2025 | T | Portland Thorns FC 1 at San Diego Wave FC 1 | Final |
| May 16, 2025 | W | Portland Thorns FC 4 at Houston Dash 1 | Final |
| June 7, 2025 | L | Portland Thorns FC 0 at Bay FC 1 | Final |
| June 15, 2025 | W | Washington Spirit 0 at Portland Thorns FC 2 | Final |
| June 21, 2025 | W | Chicago Stars FC 0 at Portland Thorns FC 1 | Final |
| August 3, 2025 | L | Portland Thorns FC 1 at Washington Spirit 2 | Final |
| August 10, 2025 | W | Seattle Reign FC 2 at Portland Thorns FC 4 | Final |
| August 16, 2025 | T | Portland Thorns FC 1 at North Carolina Courage 1 | Final |
| August 23, 2025 | L | Kansas City Current 2 at Portland Thorns FC 0 | Final |
| August 29, 2025 | L | Utah Royals FC 2 at Portland Thorns FC 1 | Final |
| September 5, 2025 | W | Portland Thorns FC 2 at Racing Louisville FC 1 | Final |
| September 14, 2025 | T | Portland Thorns FC 1 at Chicago Stars FC 1 | Final |
| September 20, 2025 | T | San Diego Wave FC 1 at Portland Thorns FC 1 | Final |
| September 26, 2025 | L | Portland Thorns FC 0 at NJ/NY Gotham FC 3 | Final |
| October 4, 2025 | W | Bay FC 1 at Portland Thorns FC 2 | Final |
| October 10, 2025 | L | Portland Thorns FC 0 at Orlando Pride 1 | Final |
| October 19, 2025 | W | Portland Thorns FC 2 at Angel City FC 0 | Final |
| November 2, 2025 | W | Houston Dash 0 at Portland Thorns FC 2 | Final |
| November 9, 2025 | W | San Diego Wave FC 0 at Portland Thorns FC 1 (Playoff) | Final |
| November 15, 2025 | L | Portland Thorns FC 0 at Washington Spirit 2 (Playoff) | Final |
Portland Thorns FC Schedule
