| | | |
| March 8, 2025 | L | Sporting Kansas City II 1 at Houston Dynamo 2 3 | Final |
| March 14, 2025 | L | St. Louis City SC 2 1 at Sporting Kansas City II 0 | Final |
| March 23, 2025 | L | Sporting Kansas City II 0 at St. Louis City SC 2 2 | Final |
| March 28, 2025 | T | Sporting Kansas City II 3 at North Texas SC 3 | Final (PK 5-4) |
| April 9, 2025 | L | Minnesota United FC 2 4 at Sporting Kansas City II 2 | Final |
| April 23, 2025 | L | Tacoma Defiance 4 at Sporting Kansas City II 1 | Final |
| April 27, 2025 | L | Sporting Kansas City II 0 at Colorado Rapids 2 3 | Final |
| May 2, 2025 | T | Sporting Kansas City II 0 at Austin FC II 0 | Final (PK 6-7) |
| May 18, 2025 | | The Town FC at Sporting Kansas City II | 1:00 p.m. |
| May 23, 2025 | | LAFC2 at Sporting Kansas City II | 7:00 p.m. |
| June 1, 2025 | | Colorado Rapids 2 at Sporting Kansas City II | 1:00 p.m. |
| June 7, 2025 | | Sporting Kansas City II at Houston Dynamo 2 | 7:00 p.m. |
| June 27, 2025 | | Sporting Kansas City II at Austin FC II | 8:30 p.m. |
| July 5, 2025 | | Portland Timbers 2 at Sporting Kansas City II | 1:00 p.m. |
| July 13, 2025 | | Sporting Kansas City II at The Town FC | 8:00 p.m. |
| July 18, 2025 | | North Texas SC at Sporting Kansas City II | 8:30 p.m. |
| July 27, 2025 | | Sporting Kansas City II at LAFC2 | 10:00 p.m. |
| July 31, 2025 | | Sporting Kansas City II at Vancouver Whitecaps FC 2 | 9:00 p.m. |
| August 3, 2025 | | Austin FC II at Sporting Kansas City II | 1:00 p.m. |
| August 8, 2025 | | Sporting Kansas City II at Minnesota United FC 2 | 8:00 p.m. |
| August 17, 2025 | | Houston Dynamo 2 at Sporting Kansas City II | 1:00 p.m. |
| August 24, 2025 | | Sporting Kansas City II at St. Louis City SC 2 | 7:00 p.m. |
| August 31, 2025 | | Colorado Rapids 2 at Sporting Kansas City II | 1:00 p.m. |
| September 6, 2025 | | Real Monarchs at Sporting Kansas City II | 8:30 p.m. |
| September 14, 2025 | | Sporting Kansas City II at North Texas SC | 8:30 p.m. |
| September 19, 2025 | | Vancouver Whitecaps FC 2 at Sporting Kansas City II | 7:00 p.m. |
| September 28, 2025 | | Ventura County FC at Sporting Kansas City II | 1:00 p.m. |
| October 5, 2025 | | Sporting Kansas City II at Minnesota United FC 2 | 4:00 p.m. |
Sporting Kansas City II Schedule
