| | | |
| May 4, 2021 | L | Scranton/Wilkes-Barre RailRiders 2 at Syracuse Mets 5 | Final |
| May 5, 2021 | W | Scranton/Wilkes-Barre RailRiders 7 at Syracuse Mets 5 | Final |
| May 6, 2021 | W | Scranton/Wilkes-Barre RailRiders 17 at Syracuse Mets 11 | Final |
| May 7, 2021 | W | Scranton/Wilkes-Barre RailRiders 7 at Syracuse Mets 3 | Final (6) |
| May 8, 2021 | W | Scranton/Wilkes-Barre RailRiders 4 at Syracuse Mets 2 | Final |
| May 9, 2021 | W | Scranton/Wilkes-Barre RailRiders 15 at Syracuse Mets 10 | Final |
| May 11, 2021 | W | Lehigh Valley IronPigs 0 at Scranton/Wilkes-Barre RailRiders 6 | Final |
| May 12, 2021 | L | Lehigh Valley IronPigs 3 at Scranton/Wilkes-Barre RailRiders 2 | Final |
| May 13, 2021 | W | Lehigh Valley IronPigs 2 at Scranton/Wilkes-Barre RailRiders 5 | Final |
| May 14, 2021 | W | Lehigh Valley IronPigs 4 at Scranton/Wilkes-Barre RailRiders 6 | Final |
| May 15, 2021 | L | Lehigh Valley IronPigs 5 at Scranton/Wilkes-Barre RailRiders 4 | Final |
| May 16, 2021 | W | Lehigh Valley IronPigs 1 at Scranton/Wilkes-Barre RailRiders 3 | Final |
| May 18, 2021 | W | Scranton/Wilkes-Barre RailRiders 11 at Rochester Red Wings 6 | Final |
| May 19, 2021 | W | Scranton/Wilkes-Barre RailRiders 3 at Rochester Red Wings 2 | Final |
| May 20, 2021 | L | Scranton/Wilkes-Barre RailRiders 3 at Rochester Red Wings 5 | Final |
| May 21, 2021 | W | Scranton/Wilkes-Barre RailRiders 6 at Rochester Red Wings 3 | Final |
| May 22, 2021 | W | Scranton/Wilkes-Barre RailRiders 9 at Rochester Red Wings 8 | Final |
| May 23, 2021 | L | Scranton/Wilkes-Barre RailRiders 1 at Rochester Red Wings 3 | Final |
| May 25, 2021 | L | Buffalo Bisons 5 at Scranton/Wilkes-Barre RailRiders 2 | Final |
| May 26, 2021 | | Buffalo Bisons at Scranton/Wilkes-Barre RailRiders | Susp. |
| May 27, 2021 | W | Buffalo Bisons 2 at Scranton/Wilkes-Barre RailRiders 4 (Game 1) | Final |
| May 27, 2021 | W | Buffalo Bisons 2 at Scranton/Wilkes-Barre RailRiders 3 (Game 2) | Final (7) |
| May 28, 2021 | | Buffalo Bisons at Scranton/Wilkes-Barre RailRiders | Ppd. |
| May 29, 2021 | W | Buffalo Bisons 2 at Scranton/Wilkes-Barre RailRiders 3 | Final |
| May 30, 2021 | | Buffalo Bisons at Scranton/Wilkes-Barre RailRiders | Ppd. |
| June 1, 2021 | L | Lehigh Valley IronPigs 5 at Scranton/Wilkes-Barre RailRiders 2 | Final |
| June 2, 2021 | W | Lehigh Valley IronPigs 2 at Scranton/Wilkes-Barre RailRiders 10 | Final |
| June 3, 2021 | W | Lehigh Valley IronPigs 1 at Scranton/Wilkes-Barre RailRiders 5 | Final |
| June 4, 2021 | L | Lehigh Valley IronPigs 5 at Scranton/Wilkes-Barre RailRiders 4 | Final |
| June 5, 2021 | L | Lehigh Valley IronPigs 9 at Scranton/Wilkes-Barre RailRiders 6 | Final |
| June 6, 2021 | W | Lehigh Valley IronPigs 3 at Scranton/Wilkes-Barre RailRiders 4 | Final |
| June 8, 2021 | W | Scranton/Wilkes-Barre RailRiders 7 at Buffalo Bisons 5 | Final |
| June 9, 2021 | | Scranton/Wilkes-Barre RailRiders at Buffalo Bisons | Ppd. |
| June 10, 2021 | W | Scranton/Wilkes-Barre RailRiders 3 at Buffalo Bisons 2 (Game 1) | Final (7) |
| June 10, 2021 | L | Scranton/Wilkes-Barre RailRiders 0 at Buffalo Bisons 10 (Game 2) | Final (7) |
| June 11, 2021 | L | Scranton/Wilkes-Barre RailRiders 2 at Buffalo Bisons 4 | Final |
| June 12, 2021 | W | Scranton/Wilkes-Barre RailRiders 6 at Buffalo Bisons 4 | Final (10) |
| June 13, 2021 | W | Scranton/Wilkes-Barre RailRiders 8 at Buffalo Bisons 0 | Final |
| June 15, 2021 | W | Syracuse Mets 6 at Scranton/Wilkes-Barre RailRiders 12 | Final |
| June 16, 2021 | W | Syracuse Mets 7 at Scranton/Wilkes-Barre RailRiders 10 | Final (10) |
| June 17, 2021 | W | Syracuse Mets 2 at Scranton/Wilkes-Barre RailRiders 4 | Final |
| June 18, 2021 | W | Syracuse Mets 5 at Scranton/Wilkes-Barre RailRiders 7 | Final |
| June 19, 2021 | | Syracuse Mets at Scranton/Wilkes-Barre RailRiders | Ppd. |
| June 20, 2021 | W | Syracuse Mets 3 at Scranton/Wilkes-Barre RailRiders 4 | Final |
| June 22, 2021 | W | Scranton/Wilkes-Barre RailRiders 14 at Lehigh Valley IronPigs 5 | Final |
| June 23, 2021 | L | Scranton/Wilkes-Barre RailRiders 2 at Lehigh Valley IronPigs 3 | Final (12) |
| June 24, 2021 | W | Scranton/Wilkes-Barre RailRiders 10 at Lehigh Valley IronPigs 2 | Final |
| June 25, 2021 | L | Scranton/Wilkes-Barre RailRiders 3 at Lehigh Valley IronPigs 6 | Final |
| June 26, 2021 | W | Scranton/Wilkes-Barre RailRiders 10 at Lehigh Valley IronPigs 4 | Final |
| June 27, 2021 | W | Scranton/Wilkes-Barre RailRiders 19 at Lehigh Valley IronPigs 1 | Final |
| June 29, 2021 | W | Scranton/Wilkes-Barre RailRiders 9 at Worcester Red Sox 7 | Final |
| June 30, 2021 | | Scranton/Wilkes-Barre RailRiders at Worcester Red Sox | Susp. |
| July 1, 2021 | L | Scranton/Wilkes-Barre RailRiders 2 at Worcester Red Sox 6 (Game 1) | Final |
| July 1, 2021 | W | Scranton/Wilkes-Barre RailRiders 1 at Worcester Red Sox 0 (Game 2) | Final (5) |
| July 2, 2021 | | Scranton/Wilkes-Barre RailRiders at Worcester Red Sox | Ppd. |
| July 3, 2021 | L | Scranton/Wilkes-Barre RailRiders 3 at Worcester Red Sox 4 | Final |
| July 4, 2021 | L | Scranton/Wilkes-Barre RailRiders 4 at Worcester Red Sox 5 | Final |
| July 6, 2021 | W | Syracuse Mets 3 at Scranton/Wilkes-Barre RailRiders 8 | Final |
| July 7, 2021 | W | Syracuse Mets 2 at Scranton/Wilkes-Barre RailRiders 3 (Game 1) | Final (7) |
| July 7, 2021 | L | Syracuse Mets 5 at Scranton/Wilkes-Barre RailRiders 0 (Game 2) | Final (6) |
| July 8, 2021 | | Syracuse Mets at Scranton/Wilkes-Barre RailRiders | Ppd. |
| July 9, 2021 | L | Syracuse Mets 2 at Scranton/Wilkes-Barre RailRiders 1 | Final (10) |
| July 10, 2021 | L | Syracuse Mets 6 at Scranton/Wilkes-Barre RailRiders 5 (Game 1) | Final (8) |
| July 10, 2021 | W | Syracuse Mets 0 at Scranton/Wilkes-Barre RailRiders 1 (Game 2) | Final (7) |
| July 11, 2021 | L | Syracuse Mets 9 at Scranton/Wilkes-Barre RailRiders 8 | Final (10) |
| July 13, 2021 | W | Scranton/Wilkes-Barre RailRiders 5 at Worcester Red Sox 2 | Final |
| July 14, 2021 | W | Scranton/Wilkes-Barre RailRiders 4 at Worcester Red Sox 3 (Game 1) | Final (7) |
| July 14, 2021 | L | Scranton/Wilkes-Barre RailRiders 2 at Worcester Red Sox 3 (Game 2) | Final (7) |
| July 15, 2021 | W | Scranton/Wilkes-Barre RailRiders 11 at Worcester Red Sox 3 | Final |
| July 16, 2021 | W | Scranton/Wilkes-Barre RailRiders 7 at Worcester Red Sox 2 | Final |
| July 17, 2021 | | Scranton/Wilkes-Barre RailRiders at Worcester Red Sox | Susp. |
| July 18, 2021 | | Scranton/Wilkes-Barre RailRiders at Worcester Red Sox (Game 2) | Ppd. |
| July 18, 2021 | | Scranton/Wilkes-Barre RailRiders at Worcester Red Sox (Game 1) | Susp. |
| July 20, 2021 | W | Rochester Red Wings 6 at Scranton/Wilkes-Barre RailRiders 7 | Final (10) |
| July 21, 2021 | W | Rochester Red Wings 0 at Scranton/Wilkes-Barre RailRiders 8 | Final |
| July 22, 2021 | L | Rochester Red Wings 9 at Scranton/Wilkes-Barre RailRiders 0 | Final |
| July 23, 2021 | W | Rochester Red Wings 5 at Scranton/Wilkes-Barre RailRiders 14 | Final |
| July 24, 2021 | W | Rochester Red Wings 1 at Scranton/Wilkes-Barre RailRiders 4 | Final |
| July 25, 2021 | L | Rochester Red Wings 7 at Scranton/Wilkes-Barre RailRiders 4 | Final |
| July 27, 2021 | L | Scranton/Wilkes-Barre RailRiders 8 at Syracuse Mets 10 | Final |
| July 28, 2021 | W | Scranton/Wilkes-Barre RailRiders 9 at Syracuse Mets 8 | Final (10) |
| July 29, 2021 | W | Scranton/Wilkes-Barre RailRiders 3 at Syracuse Mets 1 | Final |
| July 30, 2021 | L | Scranton/Wilkes-Barre RailRiders 0 at Syracuse Mets 6 | Final |
| July 31, 2021 | L | Scranton/Wilkes-Barre RailRiders 3 at Syracuse Mets 5 | Final |
| August 1, 2021 | | Scranton/Wilkes-Barre RailRiders at Syracuse Mets | Cancelled |
| August 3, 2021 | L | Worcester Red Sox 7 at Scranton/Wilkes-Barre RailRiders 2 | Final |
| August 4, 2021 | W | Worcester Red Sox 3 at Scranton/Wilkes-Barre RailRiders 7 | Final |
| August 5, 2021 | L | Worcester Red Sox 5 at Scranton/Wilkes-Barre RailRiders 3 | Final (11) |
| August 6, 2021 | L | Worcester Red Sox 4 at Scranton/Wilkes-Barre RailRiders 3 | Final (11) |
| August 7, 2021 | L | Worcester Red Sox 2 at Scranton/Wilkes-Barre RailRiders 1 | Final |
| August 8, 2021 | W | Worcester Red Sox 3 at Scranton/Wilkes-Barre RailRiders 4 | Final |
| August 10, 2021 | L | Lehigh Valley IronPigs 8 at Scranton/Wilkes-Barre RailRiders 1 | Final |
| August 11, 2021 | L | Lehigh Valley IronPigs 9 at Scranton/Wilkes-Barre RailRiders 3 | Final |
| August 12, 2021 | W | Lehigh Valley IronPigs 3 at Scranton/Wilkes-Barre RailRiders 10 | Final (8) |
| August 13, 2021 | L | Lehigh Valley IronPigs 6 at Scranton/Wilkes-Barre RailRiders 4 | Final |
| August 14, 2021 | W | Lehigh Valley IronPigs 5 at Scranton/Wilkes-Barre RailRiders 6 | Final (10) |
| August 15, 2021 | L | Lehigh Valley IronPigs 5 at Scranton/Wilkes-Barre RailRiders 4 | Final |
| August 17, 2021 | W | Scranton/Wilkes-Barre RailRiders 7 at Worcester Red Sox 4 (Game 1) | Final |
| August 17, 2021 | L | Scranton/Wilkes-Barre RailRiders 0 at Worcester Red Sox 2 (Game 2) | Final |
| August 18, 2021 | W | Scranton/Wilkes-Barre RailRiders 9 at Worcester Red Sox 1 | Final |
| August 19, 2021 | L | Scranton/Wilkes-Barre RailRiders 3 at Worcester Red Sox 5 (Game 1) | Final (7) |
| August 19, 2021 | W | Scranton/Wilkes-Barre RailRiders 5 at Worcester Red Sox 0 (Game 2) | Final (7) |
| August 20, 2021 | W | Scranton/Wilkes-Barre RailRiders 14 at Worcester Red Sox 2 | Final |
| August 21, 2021 | L | Scranton/Wilkes-Barre RailRiders 0 at Worcester Red Sox 2 | Final |
| August 22, 2021 | | Scranton/Wilkes-Barre RailRiders at Worcester Red Sox | Cancelled |
| August 24, 2021 | W | Scranton/Wilkes-Barre RailRiders 5 at Lehigh Valley IronPigs 2 | Final |
| August 25, 2021 | W | Scranton/Wilkes-Barre RailRiders 10 at Lehigh Valley IronPigs 3 | Final |
| August 26, 2021 | W | Scranton/Wilkes-Barre RailRiders 6 at Lehigh Valley IronPigs 0 | Final |
| August 27, 2021 | W | Scranton/Wilkes-Barre RailRiders 11 at Lehigh Valley IronPigs 4 | Final |
| August 28, 2021 | L | Scranton/Wilkes-Barre RailRiders 8 at Lehigh Valley IronPigs 9 | Final (12) |
| August 29, 2021 | L | Scranton/Wilkes-Barre RailRiders 5 at Lehigh Valley IronPigs 10 | Final |
| August 31, 2021 | L | Buffalo Bisons 5 at Scranton/Wilkes-Barre RailRiders 1 (Game 1) | Final (7) |
| August 31, 2021 | L | Buffalo Bisons 3 at Scranton/Wilkes-Barre RailRiders 0 (Game 2) | Final (7) |
| September 1, 2021 | | Buffalo Bisons at Scranton/Wilkes-Barre RailRiders | Cancelled |
| September 2, 2021 | L | Buffalo Bisons 5 at Scranton/Wilkes-Barre RailRiders 3 | Final |
| September 3, 2021 | L | Buffalo Bisons 1 at Scranton/Wilkes-Barre RailRiders 0 | Final |
| September 4, 2021 | L | Buffalo Bisons 8 at Scranton/Wilkes-Barre RailRiders 4 (Game 1) | Final (7) |
| September 4, 2021 | L | Buffalo Bisons 6 at Scranton/Wilkes-Barre RailRiders 2 (Game 2) | Final (7) |
| September 5, 2021 | L | Buffalo Bisons 9 at Scranton/Wilkes-Barre RailRiders 6 | Final (11) |
| September 7, 2021 | W | Rochester Red Wings 1 at Scranton/Wilkes-Barre RailRiders 4 | Final |
| September 8, 2021 | | Rochester Red Wings at Scranton/Wilkes-Barre RailRiders | Ppd. |
| September 9, 2021 | W | Rochester Red Wings 1 at Scranton/Wilkes-Barre RailRiders 5 (Game 1) | Final (7) |
| September 9, 2021 | W | Rochester Red Wings 3 at Scranton/Wilkes-Barre RailRiders 11 (Game 2) | Final (7) |
| September 10, 2021 | W | Rochester Red Wings 1 at Scranton/Wilkes-Barre RailRiders 3 | Final |
| September 11, 2021 | W | Rochester Red Wings 9 at Scranton/Wilkes-Barre RailRiders 11 | Final |
| September 12, 2021 | L | Rochester Red Wings 8 at Scranton/Wilkes-Barre RailRiders 7 | Final |
| September 14, 2021 | W | Scranton/Wilkes-Barre RailRiders 4 at Lehigh Valley IronPigs 2 | Final |
| September 15, 2021 | | Scranton/Wilkes-Barre RailRiders at Lehigh Valley IronPigs | Susp. |
| September 16, 2021 | L | Scranton/Wilkes-Barre RailRiders 5 at Lehigh Valley IronPigs 9 | Final |
| September 17, 2021 | L | Scranton/Wilkes-Barre RailRiders 8 at Lehigh Valley IronPigs 10 | Final |
| September 18, 2021 | W | Scranton/Wilkes-Barre RailRiders 6 at Lehigh Valley IronPigs 2 (Game 1) | Final |
| September 18, 2021 | W | Scranton/Wilkes-Barre RailRiders 4 at Lehigh Valley IronPigs 1 (Game 2) | Final (7) |
| September 19, 2021 | W | Scranton/Wilkes-Barre RailRiders 5 at Lehigh Valley IronPigs 1 | Final |
| September 22, 2021 | | Syracuse Mets at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| September 23, 2021 | | Syracuse Mets at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| September 24, 2021 | | Syracuse Mets at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| September 25, 2021 | | Syracuse Mets at Scranton/Wilkes-Barre RailRiders | 4:05 p.m. |
| September 26, 2021 | | Syracuse Mets at Scranton/Wilkes-Barre RailRiders | 1:05 p.m. |
| September 29, 2021 | | Scranton/Wilkes-Barre RailRiders at Rochester Red Wings | 6:05 p.m. |
| September 30, 2021 | | Scranton/Wilkes-Barre RailRiders at Rochester Red Wings | 6:05 p.m. |
| October 1, 2021 | | Scranton/Wilkes-Barre RailRiders at Rochester Red Wings | 6:05 p.m. |
| October 2, 2021 | | Scranton/Wilkes-Barre RailRiders at Rochester Red Wings | 6:05 p.m. |
| October 3, 2021 | | Scranton/Wilkes-Barre RailRiders at Rochester Red Wings | 1:05 p.m. |
Scranton/Wilkes-Barre RailRiders Schedule
