| | | |
| April 5, 2022 | W | Scranton/Wilkes-Barre RailRiders 5 at Syracuse Mets 0 | Final |
| April 6, 2022 | W | Scranton/Wilkes-Barre RailRiders 5 at Syracuse Mets 3 | Final |
| April 7, 2022 | | Scranton/Wilkes-Barre RailRiders at Syracuse Mets | Ppd. |
| April 8, 2022 | W | Scranton/Wilkes-Barre RailRiders 7 at Syracuse Mets 6 (Game 1) | Final (8) |
| April 8, 2022 | W | Scranton/Wilkes-Barre RailRiders 10 at Syracuse Mets 1 (Game 2) | Final (7) |
| April 9, 2022 | L | Scranton/Wilkes-Barre RailRiders 3 at Syracuse Mets 4 | Final (10) |
| April 10, 2022 | | Scranton/Wilkes-Barre RailRiders at Syracuse Mets | Ppd. |
| April 12, 2022 | L | Norfolk Tides 3 at Scranton/Wilkes-Barre RailRiders 1 | Final |
| April 13, 2022 | L | Norfolk Tides 5 at Scranton/Wilkes-Barre RailRiders 1 | Final |
| April 14, 2022 | L | Norfolk Tides 12 at Scranton/Wilkes-Barre RailRiders 5 | Final |
| April 15, 2022 | L | Norfolk Tides 14 at Scranton/Wilkes-Barre RailRiders 7 | Final |
| April 16, 2022 | | Norfolk Tides at Scranton/Wilkes-Barre RailRiders | Ppd. |
| April 17, 2022 | L | Norfolk Tides 5 at Scranton/Wilkes-Barre RailRiders 1 (Game 1) | Final (7) |
| April 17, 2022 | W | Norfolk Tides 0 at Scranton/Wilkes-Barre RailRiders 1 (Game 2) | Final (7) |
| April 19, 2022 | | Scranton/Wilkes-Barre RailRiders at Buffalo Bisons | Ppd. |
| April 20, 2022 | L | Scranton/Wilkes-Barre RailRiders 1 at Buffalo Bisons 2 (Game 1) | Final (7) |
| April 20, 2022 | L | Scranton/Wilkes-Barre RailRiders 5 at Buffalo Bisons 6 (Game 2) | Final (8) |
| April 21, 2022 | L | Scranton/Wilkes-Barre RailRiders 3 at Buffalo Bisons 7 | Final |
| April 22, 2022 | W | Scranton/Wilkes-Barre RailRiders 5 at Buffalo Bisons 3 | Final |
| April 23, 2022 | W | Scranton/Wilkes-Barre RailRiders 7 at Buffalo Bisons 4 | Final |
| April 24, 2022 | L | Scranton/Wilkes-Barre RailRiders 0 at Buffalo Bisons 4 | Final |
| April 26, 2022 | | Lehigh Valley IronPigs at Scranton/Wilkes-Barre RailRiders | Ppd. |
| April 27, 2022 | W | Lehigh Valley IronPigs 3 at Scranton/Wilkes-Barre RailRiders 4 | Final |
| April 28, 2022 | W | Lehigh Valley IronPigs 6 at Scranton/Wilkes-Barre RailRiders 15 | Final |
| April 29, 2022 | L | Lehigh Valley IronPigs 11 at Scranton/Wilkes-Barre RailRiders 3 (Game 1) | Final (7) |
| April 29, 2022 | L | Lehigh Valley IronPigs 7 at Scranton/Wilkes-Barre RailRiders 3 (Game 2) | Final (7) |
| April 30, 2022 | L | Lehigh Valley IronPigs 2 at Scranton/Wilkes-Barre RailRiders 0 | Final |
| May 1, 2022 | L | Lehigh Valley IronPigs 9 at Scranton/Wilkes-Barre RailRiders 3 | Final |
| May 3, 2022 | L | Scranton/Wilkes-Barre RailRiders 0 at Rochester Red Wings 2 | Final |
| May 4, 2022 | | Scranton/Wilkes-Barre RailRiders at Rochester Red Wings | Ppd. |
| May 5, 2022 | L | Scranton/Wilkes-Barre RailRiders 0 at Rochester Red Wings 2 | Final |
| May 6, 2022 | W | Scranton/Wilkes-Barre RailRiders 8 at Rochester Red Wings 7 | Final (10) |
| May 7, 2022 | L | Scranton/Wilkes-Barre RailRiders 2 at Rochester Red Wings 9 (Game 1) | Final (7) |
| May 7, 2022 | L | Scranton/Wilkes-Barre RailRiders 6 at Rochester Red Wings 7 (Game 2) | Final (10) |
| May 8, 2022 | L | Scranton/Wilkes-Barre RailRiders 1 at Rochester Red Wings 2 | Final |
| May 10, 2022 | W | Syracuse Mets 0 at Scranton/Wilkes-Barre RailRiders 2 | Final |
| May 11, 2022 | L | Syracuse Mets 8 at Scranton/Wilkes-Barre RailRiders 7 | Final |
| May 12, 2022 | L | Syracuse Mets 4 at Scranton/Wilkes-Barre RailRiders 0 | Final |
| May 13, 2022 | L | Syracuse Mets 3 at Scranton/Wilkes-Barre RailRiders 0 | Final |
| May 14, 2022 | W | Syracuse Mets 1 at Scranton/Wilkes-Barre RailRiders 4 | Final |
| May 15, 2022 | W | Syracuse Mets 1 at Scranton/Wilkes-Barre RailRiders 3 | Final |
| May 17, 2022 | L | Scranton/Wilkes-Barre RailRiders 3 at Worcester Red Sox 4 | Final |
| May 18, 2022 | L | Scranton/Wilkes-Barre RailRiders 2 at Worcester Red Sox 5 | Final |
| May 19, 2022 | L | Scranton/Wilkes-Barre RailRiders 2 at Worcester Red Sox 3 | Final |
| May 20, 2022 | L | Scranton/Wilkes-Barre RailRiders 2 at Worcester Red Sox 6 | Final |
| May 21, 2022 | W | Scranton/Wilkes-Barre RailRiders 7 at Worcester Red Sox 6 | Final |
| May 22, 2022 | W | Scranton/Wilkes-Barre RailRiders 6 at Worcester Red Sox 2 | Final |
| May 24, 2022 | L | Jacksonville Jumbo Shrimp 3 at Scranton/Wilkes-Barre RailRiders 0 | Final |
| May 25, 2022 | W | Jacksonville Jumbo Shrimp 1 at Scranton/Wilkes-Barre RailRiders 2 | Final |
| May 26, 2022 | | Jacksonville Jumbo Shrimp at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| May 27, 2022 | | Jacksonville Jumbo Shrimp at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| May 28, 2022 | | Jacksonville Jumbo Shrimp at Scranton/Wilkes-Barre RailRiders | 4:05 p.m. |
| May 29, 2022 | | Jacksonville Jumbo Shrimp at Scranton/Wilkes-Barre RailRiders | 1:05 p.m. |
| May 31, 2022 | | Lehigh Valley IronPigs at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| June 1, 2022 | | Lehigh Valley IronPigs at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| June 2, 2022 | | Lehigh Valley IronPigs at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| June 3, 2022 | | Lehigh Valley IronPigs at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| June 4, 2022 | | Lehigh Valley IronPigs at Scranton/Wilkes-Barre RailRiders | 6:05 p.m. |
| June 5, 2022 | | Lehigh Valley IronPigs at Scranton/Wilkes-Barre RailRiders | 1:05 p.m. |
| June 7, 2022 | | Scranton/Wilkes-Barre RailRiders at Syracuse Mets | 6:35 p.m. |
| June 8, 2022 | | Scranton/Wilkes-Barre RailRiders at Syracuse Mets | 6:35 p.m. |
| June 9, 2022 | | Scranton/Wilkes-Barre RailRiders at Syracuse Mets | 6:35 p.m. |
| June 10, 2022 | | Scranton/Wilkes-Barre RailRiders at Syracuse Mets | 6:35 p.m. |
| June 11, 2022 | | Scranton/Wilkes-Barre RailRiders at Syracuse Mets | 6:35 p.m. |
| June 12, 2022 | | Scranton/Wilkes-Barre RailRiders at Syracuse Mets | 1:05 p.m. |
| June 14, 2022 | | Rochester Red Wings at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| June 15, 2022 | | Rochester Red Wings at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| June 16, 2022 | | Rochester Red Wings at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| June 17, 2022 | | Rochester Red Wings at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| June 18, 2022 | | Rochester Red Wings at Scranton/Wilkes-Barre RailRiders | 6:05 p.m. |
| June 19, 2022 | | Rochester Red Wings at Scranton/Wilkes-Barre RailRiders | 1:05 p.m. |
| June 21, 2022 | | Scranton/Wilkes-Barre RailRiders at Toledo Mud Hens | 7:05 p.m. |
| June 22, 2022 | | Scranton/Wilkes-Barre RailRiders at Toledo Mud Hens | 7:05 p.m. |
| June 23, 2022 | | Scranton/Wilkes-Barre RailRiders at Toledo Mud Hens | 7:05 p.m. |
| June 24, 2022 | | Scranton/Wilkes-Barre RailRiders at Toledo Mud Hens | 7:05 p.m. |
| June 25, 2022 | | Scranton/Wilkes-Barre RailRiders at Toledo Mud Hens | 7:05 p.m. |
| June 26, 2022 | | Scranton/Wilkes-Barre RailRiders at Toledo Mud Hens | 4:05 p.m. |
| June 28, 2022 | | Buffalo Bisons at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| June 29, 2022 | | Buffalo Bisons at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| June 30, 2022 | | Buffalo Bisons at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| July 1, 2022 | | Buffalo Bisons at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| July 2, 2022 | | Buffalo Bisons at Scranton/Wilkes-Barre RailRiders | 6:05 p.m. |
| July 3, 2022 | | Buffalo Bisons at Scranton/Wilkes-Barre RailRiders | 1:05 p.m. |
| July 4, 2022 | | Scranton/Wilkes-Barre RailRiders at Worcester Red Sox | 6:45 p.m. |
| July 6, 2022 | | Scranton/Wilkes-Barre RailRiders at Worcester Red Sox | 6:45 p.m. |
| July 7, 2022 | | Scranton/Wilkes-Barre RailRiders at Worcester Red Sox | 6:45 p.m. |
| July 8, 2022 | | Scranton/Wilkes-Barre RailRiders at Worcester Red Sox | 6:45 p.m. |
| July 9, 2022 | | Scranton/Wilkes-Barre RailRiders at Worcester Red Sox | 4:05 p.m. |
| July 10, 2022 | | Scranton/Wilkes-Barre RailRiders at Worcester Red Sox | 1:05 p.m. |
| July 12, 2022 | | Louisville Bats at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| July 13, 2022 | | Louisville Bats at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| July 14, 2022 | | Louisville Bats at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| July 15, 2022 | | Louisville Bats at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| July 16, 2022 | | Louisville Bats at Scranton/Wilkes-Barre RailRiders | 6:05 p.m. |
| July 17, 2022 | | Louisville Bats at Scranton/Wilkes-Barre RailRiders | 1:05 p.m. |
| July 22, 2022 | | Scranton/Wilkes-Barre RailRiders at Lehigh Valley IronPigs | 7:05 p.m. |
| July 23, 2022 | | Scranton/Wilkes-Barre RailRiders at Lehigh Valley IronPigs | 6:35 p.m. |
| July 24, 2022 | | Scranton/Wilkes-Barre RailRiders at Lehigh Valley IronPigs | 5:35 p.m. |
| July 26, 2022 | | Scranton/Wilkes-Barre RailRiders at Rochester Red Wings | 7:05 p.m. |
| July 27, 2022 | | Scranton/Wilkes-Barre RailRiders at Rochester Red Wings | 6:05 p.m. |
| July 28, 2022 | | Scranton/Wilkes-Barre RailRiders at Rochester Red Wings | 11:05 a.m. |
| July 29, 2022 | | Scranton/Wilkes-Barre RailRiders at Rochester Red Wings | 7:05 p.m. |
| July 30, 2022 | | Scranton/Wilkes-Barre RailRiders at Rochester Red Wings | 7:05 p.m. |
| July 31, 2022 | | Scranton/Wilkes-Barre RailRiders at Rochester Red Wings | 1:05 p.m. |
| August 2, 2022 | | Buffalo Bisons at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| August 3, 2022 | | Buffalo Bisons at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| August 4, 2022 | | Buffalo Bisons at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| August 5, 2022 | | Buffalo Bisons at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| August 6, 2022 | | Buffalo Bisons at Scranton/Wilkes-Barre RailRiders | 6:05 p.m. |
| August 7, 2022 | | Buffalo Bisons at Scranton/Wilkes-Barre RailRiders | 1:05 p.m. |
| August 9, 2022 | | Worcester Red Sox at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| August 10, 2022 | | Worcester Red Sox at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| August 11, 2022 | | Worcester Red Sox at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| August 12, 2022 | | Worcester Red Sox at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| August 13, 2022 | | Worcester Red Sox at Scranton/Wilkes-Barre RailRiders | 6:05 p.m. |
| August 14, 2022 | | Worcester Red Sox at Scranton/Wilkes-Barre RailRiders | 1:05 p.m. |
| August 16, 2022 | | Scranton/Wilkes-Barre RailRiders at St. Paul Saints | 8:07 p.m. |
| August 17, 2022 | | Scranton/Wilkes-Barre RailRiders at St. Paul Saints | 8:07 p.m. |
| August 18, 2022 | | Scranton/Wilkes-Barre RailRiders at St. Paul Saints | 8:07 p.m. |
| August 19, 2022 | | Scranton/Wilkes-Barre RailRiders at St. Paul Saints | 8:07 p.m. |
| August 20, 2022 | | Scranton/Wilkes-Barre RailRiders at St. Paul Saints | 8:07 p.m. |
| August 21, 2022 | | Scranton/Wilkes-Barre RailRiders at St. Paul Saints | 3:07 p.m. |
| August 23, 2022 | | Scranton/Wilkes-Barre RailRiders at Omaha Storm Chasers | 8:05 p.m. |
| August 24, 2022 | | Scranton/Wilkes-Barre RailRiders at Omaha Storm Chasers | 8:05 p.m. |
| August 25, 2022 | | Scranton/Wilkes-Barre RailRiders at Omaha Storm Chasers | 8:05 p.m. |
| August 26, 2022 | | Scranton/Wilkes-Barre RailRiders at Omaha Storm Chasers | 8:05 p.m. |
| August 27, 2022 | | Scranton/Wilkes-Barre RailRiders at Omaha Storm Chasers | 8:05 p.m. |
| August 28, 2022 | | Scranton/Wilkes-Barre RailRiders at Omaha Storm Chasers | 3:05 p.m. |
| August 30, 2022 | | Syracuse Mets at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| August 31, 2022 | | Syracuse Mets at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| September 1, 2022 | | Syracuse Mets at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| September 2, 2022 | | Syracuse Mets at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| September 3, 2022 | | Syracuse Mets at Scranton/Wilkes-Barre RailRiders | 6:05 p.m. |
| September 4, 2022 | | Syracuse Mets at Scranton/Wilkes-Barre RailRiders | 1:05 p.m. |
| September 5, 2022 | | Scranton/Wilkes-Barre RailRiders at Durham Bulls | 5:05 p.m. |
| September 7, 2022 | | Scranton/Wilkes-Barre RailRiders at Durham Bulls | 6:35 p.m. |
| September 8, 2022 | | Scranton/Wilkes-Barre RailRiders at Durham Bulls | 6:35 p.m. |
| September 9, 2022 | | Scranton/Wilkes-Barre RailRiders at Durham Bulls | 6:35 p.m. |
| September 10, 2022 | | Scranton/Wilkes-Barre RailRiders at Durham Bulls | 6:35 p.m. |
| September 11, 2022 | | Scranton/Wilkes-Barre RailRiders at Durham Bulls | 5:05 p.m. |
| September 13, 2022 | | Worcester Red Sox at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| September 14, 2022 | | Worcester Red Sox at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| September 15, 2022 | | Worcester Red Sox at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| September 16, 2022 | | Worcester Red Sox at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| September 17, 2022 | | Worcester Red Sox at Scranton/Wilkes-Barre RailRiders | 6:05 p.m. |
| September 18, 2022 | | Worcester Red Sox at Scranton/Wilkes-Barre RailRiders | 1:05 p.m. |
| September 20, 2022 | | Scranton/Wilkes-Barre RailRiders at Lehigh Valley IronPigs | 7:05 p.m. |
| September 21, 2022 | | Scranton/Wilkes-Barre RailRiders at Lehigh Valley IronPigs | 7:05 p.m. |
| September 22, 2022 | | Scranton/Wilkes-Barre RailRiders at Lehigh Valley IronPigs | 7:05 p.m. |
| September 23, 2022 | | Scranton/Wilkes-Barre RailRiders at Lehigh Valley IronPigs | TBD |
| September 24, 2022 | | Scranton/Wilkes-Barre RailRiders at Lehigh Valley IronPigs | TBD |
| September 25, 2022 | | Scranton/Wilkes-Barre RailRiders at Lehigh Valley IronPigs | TBD |
| September 26, 2022 | | Buffalo Bisons at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| September 27, 2022 | | Buffalo Bisons at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
| September 28, 2022 | | Buffalo Bisons at Scranton/Wilkes-Barre RailRiders | 6:35 p.m. |
Scranton/Wilkes-Barre RailRiders Schedule
