| | | |
| March 27, 2022 | T | New England Revolution II 2 at New York City FC II 2 | Final (PK 4-3) |
| April 3, 2022 | W | Rochester New York FC 1 at New England Revolution II 3 | Final |
| April 17, 2022 | W | FC Cincinnati 2 2 at New England Revolution II 3 | Final |
| April 24, 2022 | T | New England Revolution II 0 at Orlando City B 0 | Final (PK 3-4) |
| May 1, 2022 | W | Inter Miami CF II 0 at New England Revolution II 1 | Final |
| May 8, 2022 | L | Columbus Crew 2 4 at New England Revolution II 0 | Final |
| May 14, 2022 | W | New England Revolution II 1 at Toronto FC II 0 | Final |
| May 22, 2022 | W | New England Revolution II 1 at FC Cincinnati 2 0 | Final |
| May 27, 2022 | W | Philadelphia Union II 0 at New England Revolution II 1 | Final |
| June 4, 2022 | | New England Revolution II at Inter Miami CF II | 7:00 p.m. |
| June 11, 2022 | | Orlando City B at New England Revolution II | 8:00 p.m. |
| June 18, 2022 | | Rochester New York FC at New England Revolution II | 7:00 p.m. |
| June 26, 2022 | | New England Revolution II at Chicago Fire FC II | 5:00 p.m. |
| July 3, 2022 | | New England Revolution II at Toronto FC II | 7:00 p.m. |
| July 10, 2022 | | New York City FC II at New England Revolution II | 6:00 p.m. |
| July 24, 2022 | | New England Revolution II at Columbus Crew 2 | 5:00 p.m. |
| July 31, 2022 | | Toronto FC II at New England Revolution II | 7:00 p.m. |
| August 7, 2022 | | New England Revolution II at Inter Miami CF II | 7:00 p.m. |
| August 14, 2022 | | Chicago Fire FC II at New England Revolution II | 6:00 p.m. |
| August 21, 2022 | | New England Revolution II at Philadelphia Union II | 7:00 p.m. |
| August 27, 2022 | | New England Revolution II at Rochester New York FC | 7:00 p.m. |
| September 2, 2022 | | Orlando City B at New England Revolution II | 5:30 p.m. |
| September 10, 2022 | | New England Revolution II at New York City FC II | 8:00 p.m. |
| September 18, 2022 | | Philadelphia Union II at New England Revolution II | 3:00 p.m. |
New England Revolution II Schedule
