| | | |
| March 7, 2025 | L | Chattanooga FC 2 at Inter Miami CF II 1 | Final |
| March 13, 2025 | T | Carolina Core FC 1 at Inter Miami CF II 1 | Final (PK 4-2) |
| March 23, 2025 | W | Columbus Crew 2 2 at Inter Miami CF II 4 | Final |
| April 6, 2025 | | Inter Miami CF II 1 at Atlanta United 2 1 | Susp. |
| April 7, 2025 | L | Inter Miami CF II 2 at Atlanta United 2 3 | Final |
| April 10, 2025 | L | Toronto FC II 1 at Inter Miami CF II 0 | Final |
| April 15, 2025 | W | Orlando City B 2 at Inter Miami CF II 3 | Final |
| April 27, 2025 | L | Inter Miami CF II 0 at Huntsville City Football Club 4 | Final |
| May 4, 2025 | W | New York City FC II 2 at Inter Miami CF II 4 | Final |
| May 9, 2025 | L | Inter Miami CF II 2 at Crown Legacy FC 4 | Final |
| May 17, 2025 | L | Inter Miami CF II 0 at Orlando City B 3 | Final |
| May 25, 2025 | W | Inter Miami CF II 1 at Philadelphia Union II 0 | Final |
| June 1, 2025 | L | Carolina Core FC 2 at Inter Miami CF II 1 | Final |
| June 7, 2025 | T | Inter Miami CF II 3 at Chattanooga FC 3 | Final (PK 4-5) |
| June 12, 2025 | L | Inter Miami CF II 0 at Toronto FC II 2 | Final |
| June 25, 2025 | L | Chicago Fire FC II 3 at Inter Miami CF II 1 | Final |
| June 29, 2025 | | Atlanta United 2 at Inter Miami CF II | Ppd. |
| July 4, 2025 | W | Inter Miami CF II 2 at Carolina Core FC 1 | Final |
| July 13, 2025 | L | Crown Legacy FC 4 at Inter Miami CF II 3 | Final |
| July 19, 2025 | T | Inter Miami CF II 2 at Chattanooga FC 2 | Final (PK 4-5) |
| July 27, 2025 | L | FC Cincinnati 2 3 at Inter Miami CF II 0 | Final |
| August 3, 2025 | W | Atlanta United 2 1 at Inter Miami CF II 2 | Final |
| August 14, 2025 | T | Huntsville City Football Club 2 at Inter Miami CF II 2 | Final (PK 3-1) |
| August 22, 2025 | L | Inter Miami CF II 0 at Crown Legacy FC 6 | Final |
| August 27, 2025 | L | Inter Miami CF II 1 at Atlanta United 2 4 | Final |
| September 7, 2025 | L | Inter Miami CF II 0 at Columbus Crew 2 4 | Final |
| September 14, 2025 | T | Orlando City B 1 at Inter Miami CF II 1 | Final (PK 5-3) |
| September 21, 2025 | T | Inter Miami CF II 1 at New York Red Bulls II 1 | Final (PK 4-2) |
| September 28, 2025 | L | Inter Miami CF II 1 at Huntsville City Football Club 4 | Final |
| October 5, 2025 | L | New England Revolution II 5 at Inter Miami CF II 2 | Final |
Inter Miami CF II Schedule
