| | | |
| May 26, 2022 | W | Scarborough Shooting Stars 80 at Guelph Nighthawks 89 | Final |
| May 31, 2022 | L | Niagara River Lions 95 at Guelph Nighthawks 84 | Final |
| June 2, 2022 | L | Guelph Nighthawks 85 at Brampton Honey Badgers 103 | Final |
| June 5, 2022 | L | Guelph Nighthawks 74 at Montreal Alliance 94 | Final |
| June 9, 2022 | W | Ottawa BlackJacks 79 at Guelph Nighthawks 86 | Final |
| June 11, 2022 | W | Montreal Alliance 84 at Guelph Nighthawks 86 | Final |
| June 14, 2022 | W | Newfoundland Growlers 82 at Guelph Nighthawks 89 | Final |
| June 16, 2022 | W | Guelph Nighthawks 83 at Ottawa BlackJacks 73 | Final |
| June 19, 2022 | W | Brampton Honey Badgers 83 at Guelph Nighthawks 89 | Final |
| June 21, 2022 | L | Vancouver Bandits 90 at Guelph Nighthawks 85 | Final |
| June 30, 2022 | L | Guelph Nighthawks 76 at Brampton Honey Badgers 95 | Final |
| July 7, 2022 | L | Guelph Nighthawks 89 at Scarborough Shooting Stars 94 | Final |
| July 9, 2022 | L | Guelph Nighthawks 88 at Niagara River Lions 101 | Final |
| July 13, 2022 | W | Montreal Alliance 80 at Guelph Nighthawks 96 | Final |
| July 15, 2022 | W | Guelph Nighthawks 87 at Vancouver Bandits 79 | Final |
| July 21, 2022 | L | Guelph Nighthawks 81 at Saskatchewan Rattlers 84 | Final |
| July 23, 2022 | L | Guelph Nighthawks 100 at Edmonton Stingers 101 | Final |
| July 27, 2022 | W | Saskatchewan Rattlers 82 at Guelph Nighthawks 104 | Final |
| July 29, 2022 | W | Guelph Nighthawks 87 at Newfoundland Growlers 80 | Final |
| August 4, 2022 | W | Guelph Nighthawks 90 at Vancouver Bandits 85 (Playoff) | Final |
| August 6, 2022 | L | Guelph Nighthawks 78 at Niagara River Lions 99 (Playoff) | Final |
Guelph Nighthawks Schedule
