| | | |
| April 4, 2025 | L | Lake County Captains 8 at Great Lakes Loons 1 | Final |
| April 5, 2025 | W | Lake County Captains 1 at Great Lakes Loons 6 | Final |
| April 6, 2025 | L | Lake County Captains 13 at Great Lakes Loons 2 | Final |
| April 8, 2025 | W | Great Lakes Loons 10 at Lansing Lugnuts 5 | Final |
| April 9, 2025 | L | Great Lakes Loons 2 at Lansing Lugnuts 8 | Final (6) |
| April 10, 2025 | W | Great Lakes Loons 3 at Lansing Lugnuts 2 | Final |
| April 11, 2025 | L | Great Lakes Loons 3 at Lansing Lugnuts 4 | Final |
| April 12, 2025 | W | Great Lakes Loons 12 at Lansing Lugnuts 6 | Final |
| April 13, 2025 | L | Great Lakes Loons 11 at Lansing Lugnuts 12 | Final (12) |
| April 15, 2025 | L | Dayton Dragons 10 at Great Lakes Loons 2 | Final |
| April 16, 2025 | W | Dayton Dragons 5 at Great Lakes Loons 10 | Final |
| April 17, 2025 | L | Dayton Dragons 9 at Great Lakes Loons 2 | Final |
| April 18, 2025 | W | Dayton Dragons 2 at Great Lakes Loons 7 | Final |
| April 19, 2025 | W | Dayton Dragons 4 at Great Lakes Loons 5 | Final |
| April 20, 2025 | W | Dayton Dragons 4 at Great Lakes Loons 8 | Final |
| April 22, 2025 | W | Great Lakes Loons 9 at Lake County Captains 3 | Final |
| April 23, 2025 | L | Great Lakes Loons 0 at Lake County Captains 4 | Final |
| April 24, 2025 | W | Great Lakes Loons 3 at Lake County Captains 1 | Final |
| April 25, 2025 | | Great Lakes Loons at Lake County Captains | Ppd. |
| April 26, 2025 | L | Great Lakes Loons 1 at Lake County Captains 6 (Game 1) | Final (7) |
| April 26, 2025 | L | Great Lakes Loons 2 at Lake County Captains 3 (Game 2) | Final (7) |
| April 27, 2025 | W | Great Lakes Loons 12 at Lake County Captains 11 | Final |
| April 29, 2025 | L | Quad Cities River Bandits 12 at Great Lakes Loons 5 | Final |
| April 30, 2025 | W | Quad Cities River Bandits 5 at Great Lakes Loons 6 | Final |
| May 1, 2025 | | Quad Cities River Bandits at Great Lakes Loons | Ppd. |
| May 2, 2025 | L | Quad Cities River Bandits 7 at Great Lakes Loons 5 | Final |
| May 3, 2025 | L | Quad Cities River Bandits 8 at Great Lakes Loons 1 (Game 1) | Final (7) |
| May 3, 2025 | L | Quad Cities River Bandits 4 at Great Lakes Loons 0 (Game 2) | Final (7) |
| May 4, 2025 | W | Quad Cities River Bandits 3 at Great Lakes Loons 7 | Final |
| May 6, 2025 | W | Great Lakes Loons 3 at Dayton Dragons 2 | Final |
| May 7, 2025 | W | Great Lakes Loons 4 at Dayton Dragons 3 | Final |
| May 8, 2025 | L | Great Lakes Loons 2 at Dayton Dragons 3 | Final (10) |
| May 9, 2025 | L | Great Lakes Loons 4 at Dayton Dragons 9 | Final |
| May 10, 2025 | W | Great Lakes Loons 13 at Dayton Dragons 5 | Final |
| May 11, 2025 | W | Great Lakes Loons 7 at Dayton Dragons 2 | Final |
| May 13, 2025 | W | Lake County Captains 1 at Great Lakes Loons 3 | Final |
| May 14, 2025 | | Lake County Captains at Great Lakes Loons | Ppd. |
| May 15, 2025 | L | Lake County Captains 9 at Great Lakes Loons 1 (Game 1) | Final (7) |
| May 15, 2025 | L | Lake County Captains 2 at Great Lakes Loons 0 (Game 2) | Final (7) |
| May 16, 2025 | W | Lake County Captains 4 at Great Lakes Loons 11 | Final |
| May 17, 2025 | W | Lake County Captains 6 at Great Lakes Loons 7 | Final |
| May 18, 2025 | W | Lake County Captains 1 at Great Lakes Loons 9 | Final |
| May 20, 2025 | | Great Lakes Loons at West Michigan Whitecaps | Ppd. |
| May 21, 2025 | | Great Lakes Loons at West Michigan Whitecaps (Game 2) | Ppd. |
| May 21, 2025 | | Great Lakes Loons at West Michigan Whitecaps (Game 1) | Susp. |
| May 22, 2025 | L | Great Lakes Loons 1 at West Michigan Whitecaps 2 (Game 1) | Final (7) |
| May 22, 2025 | L | Great Lakes Loons 1 at West Michigan Whitecaps 7 (Game 2) | Final (7) |
| May 23, 2025 | W | Great Lakes Loons 3 at West Michigan Whitecaps 2 | Final |
| May 24, 2025 | W | Great Lakes Loons 4 at West Michigan Whitecaps 0 (Game 1) | Final (7) |
| May 24, 2025 | L | Great Lakes Loons 3 at West Michigan Whitecaps 4 (Game 2) | Final (8) |
| May 25, 2025 | L | Great Lakes Loons 2 at West Michigan Whitecaps 5 | Final |
| May 27, 2025 | W | Fort Wayne TinCaps 1 at Great Lakes Loons 4 | Final |
| May 28, 2025 | W | Fort Wayne TinCaps 1 at Great Lakes Loons 10 | Final |
| May 29, 2025 | L | Fort Wayne TinCaps 7 at Great Lakes Loons 5 | Final |
| May 30, 2025 | W | Fort Wayne TinCaps 4 at Great Lakes Loons 10 | Final |
| May 31, 2025 | L | Fort Wayne TinCaps 6 at Great Lakes Loons 2 | Final |
| June 1, 2025 | W | Fort Wayne TinCaps 5 at Great Lakes Loons 6 | Final |
| June 3, 2025 | L | Great Lakes Loons 3 at South Bend Cubs 11 | Final |
| June 4, 2025 | | Great Lakes Loons at South Bend Cubs | Ppd. |
| June 5, 2025 | L | Great Lakes Loons 5 at South Bend Cubs 6 (Game 1) | Final (7) |
| June 5, 2025 | W | Great Lakes Loons 3 at South Bend Cubs 0 (Game 2) | Final (7) |
| June 6, 2025 | | Great Lakes Loons at South Bend Cubs | Susp. |
| June 7, 2025 | W | Great Lakes Loons 2 at South Bend Cubs 1 (Game 1) | Final |
| June 7, 2025 | W | Great Lakes Loons 2 at South Bend Cubs 1 (Game 2) | Final (7) |
| June 8, 2025 | L | Great Lakes Loons 2 at South Bend Cubs 11 | Final |
| June 10, 2025 | L | Wisconsin Timber Rattlers 10 at Great Lakes Loons 3 | Final |
| June 11, 2025 | W | Wisconsin Timber Rattlers 2 at Great Lakes Loons 4 | Final |
| June 12, 2025 | L | Wisconsin Timber Rattlers 9 at Great Lakes Loons 2 | Final |
| June 13, 2025 | L | Wisconsin Timber Rattlers 6 at Great Lakes Loons 4 | Final |
| June 14, 2025 | W | Wisconsin Timber Rattlers 2 at Great Lakes Loons 9 | Final |
| June 15, 2025 | L | Wisconsin Timber Rattlers 10 at Great Lakes Loons 4 | Final |
| June 17, 2025 | W | Peoria Chiefs 7 at Great Lakes Loons 8 | Final |
| June 18, 2025 | | Peoria Chiefs at Great Lakes Loons | Cancelled |
| June 19, 2025 | W | Peoria Chiefs 4 at Great Lakes Loons 13 | Final |
| June 20, 2025 | L | Peoria Chiefs 7 at Great Lakes Loons 1 | Final |
| June 21, 2025 | W | Peoria Chiefs 6 at Great Lakes Loons 8 | Final |
| June 22, 2025 | W | Peoria Chiefs 5 at Great Lakes Loons 6 | Final |
| June 24, 2025 | L | Great Lakes Loons 7 at Fort Wayne TinCaps 8 | Final |
| June 25, 2025 | W | Great Lakes Loons 11 at Fort Wayne TinCaps 0 | Final |
| June 26, 2025 | L | Great Lakes Loons 1 at Fort Wayne TinCaps 7 | Final |
| June 27, 2025 | W | Great Lakes Loons 8 at Fort Wayne TinCaps 0 | Final |
| June 28, 2025 | L | Great Lakes Loons 1 at Fort Wayne TinCaps 2 | Final |
| June 29, 2025 | L | Great Lakes Loons 7 at Fort Wayne TinCaps 8 | Final |
| July 1, 2025 | W | Great Lakes Loons 14 at West Michigan Whitecaps 9 | Final |
| July 2, 2025 | W | Great Lakes Loons 5 at West Michigan Whitecaps 2 | Final |
| July 3, 2025 | L | Great Lakes Loons 1 at West Michigan Whitecaps 2 | Final (10) |
| July 4, 2025 | L | West Michigan Whitecaps 15 at Great Lakes Loons 1 | Final |
| July 5, 2025 | W | West Michigan Whitecaps 3 at Great Lakes Loons 7 | Final |
| July 6, 2025 | W | West Michigan Whitecaps 2 at Great Lakes Loons 4 | Final |
| July 8, 2025 | W | Lansing Lugnuts 2 at Great Lakes Loons 3 | Final |
| July 9, 2025 | | Lansing Lugnuts at Great Lakes Loons | Ppd. |
| July 10, 2025 | L | Lansing Lugnuts 10 at Great Lakes Loons 1 (Game 1) | Final (7) |
| July 10, 2025 | W | Lansing Lugnuts 1 at Great Lakes Loons 4 (Game 2) | Final (7) |
| July 11, 2025 | L | Lansing Lugnuts 6 at Great Lakes Loons 3 | Final |
| July 12, 2025 | L | Lansing Lugnuts 9 at Great Lakes Loons 2 | Final |
| July 13, 2025 | L | Lansing Lugnuts 3 at Great Lakes Loons 1 | Final |
| July 18, 2025 | W | Great Lakes Loons 5 at Dayton Dragons 4 | Final |
| July 19, 2025 | W | Great Lakes Loons 4 at Dayton Dragons 1 | Final |
| July 20, 2025 | | Great Lakes Loons at Dayton Dragons | Cancelled |
| July 22, 2025 | W | Beloit Sky Carp 4 at Great Lakes Loons 7 | Final |
| July 23, 2025 | W | Beloit Sky Carp 5 at Great Lakes Loons 6 | Final (10) |
| July 24, 2025 | W | Beloit Sky Carp 2 at Great Lakes Loons 9 | Final |
| July 25, 2025 | W | Beloit Sky Carp 1 at Great Lakes Loons 5 | Final |
| July 26, 2025 | W | Beloit Sky Carp 2 at Great Lakes Loons 7 | Final |
| July 27, 2025 | L | Beloit Sky Carp 3 at Great Lakes Loons 0 | Final |
| July 29, 2025 | W | Great Lakes Loons 6 at Fort Wayne TinCaps 0 | Final |
| July 30, 2025 | L | Great Lakes Loons 3 at Fort Wayne TinCaps 4 | Final (10) |
| July 31, 2025 | W | Great Lakes Loons 2 at Fort Wayne TinCaps 0 | Final |
| August 1, 2025 | W | Great Lakes Loons 9 at Fort Wayne TinCaps 2 | Final |
| August 2, 2025 | W | Great Lakes Loons 18 at Fort Wayne TinCaps 3 | Final |
| August 3, 2025 | L | Great Lakes Loons 2 at Fort Wayne TinCaps 5 | Final |
| August 5, 2025 | L | Lansing Lugnuts 6 at Great Lakes Loons 3 | Final (10) |
| August 6, 2025 | L | Lansing Lugnuts 3 at Great Lakes Loons 1 | Final |
| August 7, 2025 | W | Lansing Lugnuts 6 at Great Lakes Loons 7 | Final |
| August 8, 2025 | W | Lansing Lugnuts 6 at Great Lakes Loons 8 | Final (10) |
| August 9, 2025 | W | Lansing Lugnuts 1 at Great Lakes Loons 6 | Final |
| August 10, 2025 | W | Lansing Lugnuts 1 at Great Lakes Loons 4 | Final |
| August 12, 2025 | L | Great Lakes Loons 3 at Wisconsin Timber Rattlers 4 | Final |
| August 13, 2025 | W | Great Lakes Loons 7 at Wisconsin Timber Rattlers 3 | Final |
| August 14, 2025 | L | Great Lakes Loons 6 at Wisconsin Timber Rattlers 8 | Final |
| August 15, 2025 | W | Great Lakes Loons 16 at Wisconsin Timber Rattlers 5 | Final |
| August 16, 2025 | W | Great Lakes Loons 7 at Wisconsin Timber Rattlers 0 | Final |
| August 17, 2025 | W | Great Lakes Loons 5 at Wisconsin Timber Rattlers 3 | Final |
| August 19, 2025 | L | Great Lakes Loons 4 at Quad Cities River Bandits 13 | Final |
| August 20, 2025 | W | Great Lakes Loons 2 at Quad Cities River Bandits 1 | Final |
| August 21, 2025 | W | Great Lakes Loons 7 at Quad Cities River Bandits 1 | Final |
| August 22, 2025 | W | Great Lakes Loons 12 at Quad Cities River Bandits 3 | Final |
| August 23, 2025 | L | Great Lakes Loons 3 at Quad Cities River Bandits 6 | Final |
| August 24, 2025 | L | Great Lakes Loons 3 at Quad Cities River Bandits 4 | Final |
| August 26, 2025 | L | West Michigan Whitecaps 2 at Great Lakes Loons 1 | Final |
| August 27, 2025 | W | West Michigan Whitecaps 2 at Great Lakes Loons 6 | Final |
| August 28, 2025 | L | West Michigan Whitecaps 2 at Great Lakes Loons 1 | Final (10) |
| August 29, 2025 | W | West Michigan Whitecaps 1 at Great Lakes Loons 8 | Final |
| August 30, 2025 | W | West Michigan Whitecaps 4 at Great Lakes Loons 6 | Final |
| August 31, 2025 | L | West Michigan Whitecaps 7 at Great Lakes Loons 2 | Final |
| September 2, 2025 | L | Great Lakes Loons 6 at Lake County Captains 7 | Final (10) |
| September 3, 2025 | W | Great Lakes Loons 11 at Lake County Captains 5 | Final |
| September 4, 2025 | L | Great Lakes Loons 3 at Lake County Captains 4 | Final |
| September 5, 2025 | L | Great Lakes Loons 2 at Lake County Captains 3 | Final |
| September 6, 2025 | W | Great Lakes Loons 9 at Lake County Captains 2 | Final |
| September 7, 2025 | W | Great Lakes Loons 9 at Lake County Captains 5 | Final |
Great Lakes Loons Schedule
