| | | |
| March 26, 2022 | L | Chicago Fire FC II 0 at Orlando City B 2 | Final |
| April 3, 2022 | L | Columbus Crew 2 1 at Chicago Fire FC II 0 | Final |
| April 10, 2022 | T | Rochester New York FC 0 at Chicago Fire FC II 0 | Final (PK 6-5) |
| April 17, 2022 | L | Chicago Fire FC II 2 at Toronto FC II 4 | Final |
| April 24, 2022 | T | Philadelphia Union II 3 at Chicago Fire FC II 3 | Final (PK 4-5) |
| May 8, 2022 | T | Minnesota United FC 2 0 at Chicago Fire FC II 0 | Final (PK 7-6) |
| May 15, 2022 | W | FC Cincinnati 2 1 at Chicago Fire FC II 3 | Final |
| May 21, 2022 | | Chicago Fire FC II at New York City FC II | 6:00 p.m. |
| May 27, 2022 | | Chicago Fire FC II at Toronto FC II | 7:00 p.m. |
| June 4, 2022 | | Columbus Crew 2 at Chicago Fire FC II | 6:00 p.m. |
| June 11, 2022 | | St. Louis City SC 2 at Chicago Fire FC II | 8:00 p.m. |
| June 19, 2022 | | Chicago Fire FC II at Philadelphia Union II | 2:00 p.m. |
| June 26, 2022 | | New England Revolution II at Chicago Fire FC II | 5:00 p.m. |
| July 2, 2022 | | Chicago Fire FC II at Inter Miami CF II | 7:00 p.m. |
| July 10, 2022 | | Chicago Fire FC II at FC Cincinnati 2 | 6:00 p.m. |
| July 17, 2022 | | Orlando City B at Chicago Fire FC II | 7:00 p.m. |
| July 30, 2022 | | Chicago Fire FC II at Rochester New York FC | 7:00 p.m. |
| August 6, 2022 | | Chicago Fire FC II at St. Louis City SC 2 | 9:00 p.m. |
| August 14, 2022 | | Chicago Fire FC II at New England Revolution II | 6:00 p.m. |
| August 20, 2022 | | New York City FC II at Chicago Fire FC II | 8:00 p.m. |
| August 25, 2022 | | Toronto FC II at Chicago Fire FC II | 8:00 p.m. |
| September 4, 2022 | | Chicago Fire FC II at Columbus Crew 2 | 4:00 p.m. |
| September 11, 2022 | | Chicago Fire FC II at FC Cincinnati 2 | 4:00 p.m. |
| September 18, 2022 | | Inter Miami CF II at Chicago Fire FC II | 3:00 p.m. |
Chicago Fire FC II Schedule
