| | | |
| March 27, 2026 | L | Scranton/Wilkes-Barre RailRiders 8 at Buffalo Bisons 0 | Final |
| March 28, 2026 | | Scranton/Wilkes-Barre RailRiders at Buffalo Bisons | Ppd. |
| March 29, 2026 | L | Scranton/Wilkes-Barre RailRiders 5 at Buffalo Bisons 4 (Game 1) | Final (10) |
| March 29, 2026 | W | Scranton/Wilkes-Barre RailRiders 3 at Buffalo Bisons 7 (Game 2) | Final (7) |
| March 31, 2026 | W | Buffalo Bisons 6 at Omaha Storm Chasers 4 | Final |
| April 1, 2026 | L | Buffalo Bisons 0 at Omaha Storm Chasers 3 | Final |
| April 2, 2026 | L | Buffalo Bisons 7 at Omaha Storm Chasers 9 | Final |
| April 3, 2026 | | Buffalo Bisons at Omaha Storm Chasers | Ppd. |
| April 4, 2026 | W | Buffalo Bisons 8 at Omaha Storm Chasers 0 (Game 1) | Final (7) |
| April 4, 2026 | L | Buffalo Bisons 4 at Omaha Storm Chasers 6 (Game 2) | Final (7) |
| April 5, 2026 | L | Buffalo Bisons 3 at Omaha Storm Chasers 4 | Final |
| April 7, 2026 | | Syracuse Mets at Buffalo Bisons | Ppd. |
| April 8, 2026 | W | Syracuse Mets 0 at Buffalo Bisons 2 (Game 1) | Final (7) |
| April 8, 2026 | W | Syracuse Mets 3 at Buffalo Bisons 4 (Game 2) | Final (7) |
| April 9, 2026 | L | Syracuse Mets 5 at Buffalo Bisons 4 | Final |
| April 10, 2026 | W | Syracuse Mets 1 at Buffalo Bisons 7 | Final (6) |
| April 11, 2026 | W | Syracuse Mets 0 at Buffalo Bisons 5 | Final |
| April 12, 2026 | L | Syracuse Mets 3 at Buffalo Bisons 2 | Final |
| April 14, 2026 | W | Buffalo Bisons 5 at Rochester Red Wings 3 | Final |
| April 15, 2026 | L | Buffalo Bisons 3 at Rochester Red Wings 6 | Final |
| April 16, 2026 | | Buffalo Bisons at Rochester Red Wings | Ppd. |
| April 17, 2026 | W | Buffalo Bisons 6 at Rochester Red Wings 2 (Game 1) | Final (7) |
| April 17, 2026 | L | Buffalo Bisons 3 at Rochester Red Wings 5 (Game 2) | Final (7) |
| April 18, 2026 | W | Buffalo Bisons 6 at Rochester Red Wings 3 | Final |
| April 19, 2026 | L | Buffalo Bisons 4 at Rochester Red Wings 6 | Final |
| April 21, 2026 | L | Columbus Clippers 5 at Buffalo Bisons 2 | Final |
| April 22, 2026 | W | Columbus Clippers 3 at Buffalo Bisons 5 | Final |
| April 23, 2026 | W | Columbus Clippers 5 at Buffalo Bisons 6 | Final (10) |
| April 24, 2026 | L | Columbus Clippers 12 at Buffalo Bisons 6 | Final |
| April 25, 2026 | | Columbus Clippers at Buffalo Bisons | Ppd. |
| April 26, 2026 | W | Columbus Clippers 3 at Buffalo Bisons 6 (Game 1) | Final (7) |
| April 26, 2026 | L | Columbus Clippers 6 at Buffalo Bisons 4 (Game 2) | Final (8) |
| April 28, 2026 | L | Buffalo Bisons 6 at Scranton/Wilkes-Barre RailRiders 9 | Final |
| April 29, 2026 | | Buffalo Bisons at Scranton/Wilkes-Barre RailRiders | Ppd. |
| April 30, 2026 | L | Buffalo Bisons 4 at Scranton/Wilkes-Barre RailRiders 5 | Final (10) |
| May 1, 2026 | L | Buffalo Bisons 0 at Scranton/Wilkes-Barre RailRiders 2 (Game 1) | Final (7) |
| May 1, 2026 | W | Buffalo Bisons 8 at Scranton/Wilkes-Barre RailRiders 3 (Game 2) | Final (7) |
| May 2, 2026 | W | Buffalo Bisons 4 at Scranton/Wilkes-Barre RailRiders 2 | Final (11) |
| May 3, 2026 | L | Buffalo Bisons 1 at Scranton/Wilkes-Barre RailRiders 7 | Final |
| May 5, 2026 | L | Buffalo Bisons 5 at Lehigh Valley IronPigs 7 | Final |
| May 6, 2026 | W | Buffalo Bisons 11 at Lehigh Valley IronPigs 1 | Final |
| May 7, 2026 | W | Buffalo Bisons 13 at Lehigh Valley IronPigs 5 | Final |
| May 8, 2026 | L | Buffalo Bisons 0 at Lehigh Valley IronPigs 4 | Final |
| May 9, 2026 | W | Buffalo Bisons 9 at Lehigh Valley IronPigs 7 | Final |
| May 10, 2026 | W | Buffalo Bisons 11 at Lehigh Valley IronPigs 2 | Final |
| May 12, 2026 | W | Worcester Red Sox 2 at Buffalo Bisons 7 | Final |
| May 13, 2026 | L | Worcester Red Sox 6 at Buffalo Bisons 2 | Final |
| May 14, 2026 | W | Worcester Red Sox 3 at Buffalo Bisons 4 | Final |
| May 15, 2026 | W | Worcester Red Sox 2 at Buffalo Bisons 5 | Final |
| May 16, 2026 | W | Worcester Red Sox 0 at Buffalo Bisons 2 | Final (5) |
| May 17, 2026 | L | Worcester Red Sox 4 at Buffalo Bisons 0 | Final |
| May 19, 2026 | L | Buffalo Bisons 5 at Syracuse Mets 9 | Final |
| May 20, 2026 | L | Buffalo Bisons 5 at Syracuse Mets 10 | Final |
| May 21, 2026 | L | Buffalo Bisons 8 at Syracuse Mets 12 | Final |
| May 22, 2026 | W | Buffalo Bisons 4 at Syracuse Mets 2 | Final |
| May 23, 2026 | | Buffalo Bisons at Syracuse Mets | Ppd. |
| May 24, 2026 | W | Buffalo Bisons 6 at Syracuse Mets 4 (Game 1) | Final (7) |
| May 24, 2026 | L | Buffalo Bisons 0 at Syracuse Mets 1 (Game 2) | Final (7) |
| May 26, 2026 | W | Lehigh Valley IronPigs 4 at Buffalo Bisons 5 | Final (10) |
| May 27, 2026 | L | Lehigh Valley IronPigs 7 at Buffalo Bisons 6 | Final |
| May 28, 2026 | L | Lehigh Valley IronPigs 9 at Buffalo Bisons 4 | Final |
| May 29, 2026 | L | Lehigh Valley IronPigs 5 at Buffalo Bisons 4 | Final (11) |
| May 30, 2026 | W | Lehigh Valley IronPigs 5 at Buffalo Bisons 6 | Final |
| May 31, 2026 | L | Lehigh Valley IronPigs 8 at Buffalo Bisons 5 | Final |
| June 2, 2026 | L | Buffalo Bisons 2 at Worcester Red Sox 3 | Final |
| June 3, 2026 | W | Buffalo Bisons 12 at Worcester Red Sox 0 | Final |
| June 4, 2026 | L | Buffalo Bisons 1 at Worcester Red Sox 5 | Final |
| June 5, 2026 | L | Buffalo Bisons 3 at Worcester Red Sox 6 | Final |
| June 6, 2026 | L | Buffalo Bisons 4 at Worcester Red Sox 7 | Final |
| June 7, 2026 | L | Buffalo Bisons 3 at Worcester Red Sox 5 | Final |
| June 9, 2026 | W | Syracuse Mets 2 at Buffalo Bisons 7 | Final (6) |
| June 10, 2026 | L | Syracuse Mets 8 at Buffalo Bisons 2 | Final |
| June 11, 2026 | W | Syracuse Mets 1 at Buffalo Bisons 3 | Final |
| June 12, 2026 | W | Syracuse Mets 1 at Buffalo Bisons 4 | Final |
| June 13, 2026 | W | Syracuse Mets 7 at Buffalo Bisons 8 | Final (10) |
| June 14, 2026 | W | Syracuse Mets 3 at Buffalo Bisons 4 | Final (7) |
| June 16, 2026 | W | Charlotte Knights 5 at Buffalo Bisons 9 | Final |
| June 17, 2026 | L | Charlotte Knights 5 at Buffalo Bisons 1 | Final |
| June 18, 2026 | L | Charlotte Knights 4 at Buffalo Bisons 0 | Final |
| June 19, 2026 | L | Charlotte Knights 10 at Buffalo Bisons 5 | Final |
| June 20, 2026 | W | Charlotte Knights 2 at Buffalo Bisons 4 | Final |
| June 21, 2026 | L | Charlotte Knights 5 at Buffalo Bisons 0 | Final |
| June 23, 2026 | W | Buffalo Bisons 11 at Iowa Cubs 10 | Final (10) |
| June 24, 2026 | L | Buffalo Bisons 11 at Iowa Cubs 18 | Final |
| June 25, 2026 | W | Buffalo Bisons 15 at Iowa Cubs 1 | Final |
| June 26, 2026 | L | Buffalo Bisons 1 at Iowa Cubs 12 | Final |
| June 27, 2026 | W | Buffalo Bisons 9 at Iowa Cubs 3 | Final (11) |
| June 28, 2026 | W | Buffalo Bisons 8 at Iowa Cubs 5 | Final |
| June 30, 2026 | L | Buffalo Bisons 6 at St. Paul Saints 12 | Final |
| July 1, 2026 | W | Buffalo Bisons 3 at St. Paul Saints 2 | Final |
| July 2, 2026 | W | Buffalo Bisons 16 at St. Paul Saints 1 | Final |
| July 3, 2026 | L | Buffalo Bisons 3 at St. Paul Saints 4 | Final |
| July 4, 2026 | L | Buffalo Bisons 5 at St. Paul Saints 6 | Final (6) |
| July 5, 2026 | W | Buffalo Bisons 8 at St. Paul Saints 3 | Final |
| July 7, 2026 | L | Scranton/Wilkes-Barre RailRiders 18 at Buffalo Bisons 3 | Final |
| July 8, 2026 | L | Scranton/Wilkes-Barre RailRiders 5 at Buffalo Bisons 1 | Final |
| July 9, 2026 | | Scranton/Wilkes-Barre RailRiders at Buffalo Bisons | Ppd. |
| July 10, 2026 | L | Scranton/Wilkes-Barre RailRiders 9 at Buffalo Bisons 1 | Final |
| July 11, 2026 | W | Scranton/Wilkes-Barre RailRiders 2 at Buffalo Bisons 5 (Game 1) | Final (7) |
| July 11, 2026 | W | Scranton/Wilkes-Barre RailRiders 1 at Buffalo Bisons 3 (Game 2) | Final (7) |
| July 12, 2026 | L | Scranton/Wilkes-Barre RailRiders 8 at Buffalo Bisons 7 | Final (10) |
| July 17, 2026 | W | Buffalo Bisons 7 at Syracuse Mets 5 | Final |
| July 18, 2026 | L | Buffalo Bisons 2 at Syracuse Mets 15 | Final |
| July 19, 2026 | W | Buffalo Bisons 7 at Syracuse Mets 3 | Final |
| July 21, 2026 | L | Rochester Red Wings 7 at Buffalo Bisons 3 | Final |
| July 22, 2026 | W | Rochester Red Wings 2 at Buffalo Bisons 9 | Final |
| July 23, 2026 | L | Rochester Red Wings 5 at Buffalo Bisons 2 | Final (10) |
| July 24, 2026 | W | Rochester Red Wings 6 at Buffalo Bisons 7 | Final |
| July 25, 2026 | W | Rochester Red Wings 1 at Buffalo Bisons 3 | Final |
| July 26, 2026 | L | Rochester Red Wings 5 at Buffalo Bisons 4 | Final |
| July 28, 2026 | | Buffalo Bisons at Lehigh Valley IronPigs | Ppd. |
| July 29, 2026 | W | Buffalo Bisons 5 at Lehigh Valley IronPigs 4 | Final |
| July 30, 2026 | W | Buffalo Bisons 1 at Lehigh Valley IronPigs 0 (Game 1) | Final (7) |
| July 30, 2026 | L | Buffalo Bisons 3 at Lehigh Valley IronPigs 5 (Game 2) | Final (7) |
| July 31, 2026 | L | Buffalo Bisons 2 at Lehigh Valley IronPigs 7 | Final |
| August 1, 2026 | L | Buffalo Bisons 1 at Lehigh Valley IronPigs 4 | Final |
| August 2, 2026 | W | Buffalo Bisons 8 at Lehigh Valley IronPigs 5 | Final |
| August 4, 2026 | L | Norfolk Tides 10 at Buffalo Bisons 6 | Final |
| August 5, 2026 | W | Norfolk Tides 6 at Buffalo Bisons 7 | Final |
| August 6, 2026 | W | Norfolk Tides 4 at Buffalo Bisons 7 | Final |
| August 7, 2026 | L | Norfolk Tides 6 at Buffalo Bisons 3 | Final (10) |
| August 8, 2026 | W | Norfolk Tides 8 at Buffalo Bisons 10 | Final |
| August 9, 2026 | W | Norfolk Tides 3 at Buffalo Bisons 9 | Final |
| August 11, 2026 | W | Buffalo Bisons 9 at Worcester Red Sox 6 | Final |
| August 12, 2026 | L | Buffalo Bisons 1 at Worcester Red Sox 2 | Final |
| August 13, 2026 | L | Buffalo Bisons 3 at Worcester Red Sox 10 | Final |
| August 14, 2026 | W | Buffalo Bisons 6 at Worcester Red Sox 2 | Final |
| August 15, 2026 | W | Buffalo Bisons 7 at Worcester Red Sox 5 | Final (10) |
| August 16, 2026 | W | Buffalo Bisons 9 at Worcester Red Sox 6 | Final |
| August 18, 2026 | L | Lehigh Valley IronPigs 5 at Buffalo Bisons 1 | Final |
| August 19, 2026 | L | Lehigh Valley IronPigs 2 at Buffalo Bisons 1 | Final |
| August 20, 2026 | L | Lehigh Valley IronPigs 7 at Buffalo Bisons 5 | Final |
| August 21, 2026 | W | Lehigh Valley IronPigs 0 at Buffalo Bisons 8 | Final |
| August 22, 2026 | | Lehigh Valley IronPigs at Buffalo Bisons | Cancelled |
| August 23, 2026 | W | Lehigh Valley IronPigs 2 at Buffalo Bisons 10 | Final |
| August 25, 2026 | W | Buffalo Bisons 6 at Rochester Red Wings 3 | Final |
| August 26, 2026 | L | Buffalo Bisons 3 at Rochester Red Wings 6 | Final |
| August 27, 2026 | L | Buffalo Bisons 6 at Rochester Red Wings 7 | Final |
| August 28, 2026 | L | Buffalo Bisons 3 at Rochester Red Wings 5 | Final |
| August 29, 2026 | W | Buffalo Bisons 6 at Rochester Red Wings 1 | Final |
| August 30, 2026 | L | Buffalo Bisons 7 at Rochester Red Wings 9 | Final |
| September 1, 2026 | L | Worcester Red Sox 9 at Buffalo Bisons 1 | Final |
| September 2, 2026 | | Worcester Red Sox at Buffalo Bisons | Ppd. |
| September 3, 2026 | | Worcester Red Sox at Buffalo Bisons | Susp. |
| September 4, 2026 | L | Worcester Red Sox 6 at Buffalo Bisons 4 (Game 1) | Final (10) |
| September 4, 2026 | L | Worcester Red Sox 10 at Buffalo Bisons 0 (Game 2) | Final |
| September 4, 2026 | L | Worcester Red Sox 10 at Buffalo Bisons 0 | Final |
| September 5, 2026 | L | Worcester Red Sox 4 at Buffalo Bisons 2 | Final |
| September 6, 2026 | W | Worcester Red Sox 7 at Buffalo Bisons 8 | Final |
| September 8, 2026 | L | Buffalo Bisons 1 at Charlotte Knights 4 | Final |
| September 9, 2026 | L | Buffalo Bisons 4 at Charlotte Knights 5 | Final |
| September 10, 2026 | W | Buffalo Bisons 11 at Charlotte Knights 4 | Final |
| September 11, 2026 | L | Buffalo Bisons 1 at Charlotte Knights 2 | Final |
| September 12, 2026 | L | Buffalo Bisons 1 at Charlotte Knights 10 | Final (7) |
| September 12, 2026 | | Buffalo Bisons at Charlotte Knights | Cancelled |
| September 15, 2026 | W | Rochester Red Wings 8 at Buffalo Bisons 9 | Final |
| September 16, 2026 | L | Rochester Red Wings 12 at Buffalo Bisons 4 | Final |
| September 17, 2026 | L | Rochester Red Wings 3 at Buffalo Bisons 1 | Final |
| September 18, 2026 | W | Rochester Red Wings 1 at Buffalo Bisons 7 | Final |
| September 19, 2026 | L | Rochester Red Wings 7 at Buffalo Bisons 3 | Final |
| September 20, 2026 | L | Rochester Red Wings 15 at Buffalo Bisons 8 | Final |
Buffalo Bisons Schedule
