| | | |
| March 28, 2025 | W | Rochester Red Wings 2 at Buffalo Bisons 6 | Final |
| March 29, 2025 | L | Rochester Red Wings 8 at Buffalo Bisons 3 | Final (8) |
| March 30, 2025 | | Rochester Red Wings at Buffalo Bisons | Ppd. |
| April 1, 2025 | L | Buffalo Bisons 7 at Memphis Redbirds 13 | Final |
| April 2, 2025 | L | Buffalo Bisons 3 at Memphis Redbirds 15 | Final |
| April 3, 2025 | | Buffalo Bisons at Memphis Redbirds | Ppd. |
| April 4, 2025 | L | Buffalo Bisons 1 at Memphis Redbirds 4 (Game 1) | Final (7) |
| April 4, 2025 | L | Buffalo Bisons 1 at Memphis Redbirds 3 (Game 2) | Final (7) |
| April 5, 2025 | | Buffalo Bisons at Memphis Redbirds | Ppd. |
| April 6, 2025 | | Buffalo Bisons at Memphis Redbirds (Game 1) | Cancelled |
| April 6, 2025 | | Buffalo Bisons at Memphis Redbirds (Game 2) | Cancelled |
| April 8, 2025 | | Durham Bulls at Buffalo Bisons | Ppd. |
| April 9, 2025 | L | Durham Bulls 7 at Buffalo Bisons 1 (Game 1) | Final (7) |
| April 9, 2025 | W | Durham Bulls 1 at Buffalo Bisons 2 (Game 2) | Final (7) |
| April 10, 2025 | | Durham Bulls at Buffalo Bisons | Ppd. |
| April 11, 2025 | W | Durham Bulls 5 at Buffalo Bisons 8 | Final |
| April 12, 2025 | L | Durham Bulls 4 at Buffalo Bisons 1 (Game 1) | Final (7) |
| April 12, 2025 | L | Durham Bulls 2 at Buffalo Bisons 1 (Game 2) | Final (7) |
| April 13, 2025 | W | Durham Bulls 3 at Buffalo Bisons 5 | Final |
| April 15, 2025 | L | Buffalo Bisons 2 at Syracuse Mets 10 | Final (6) |
| April 16, 2025 | | Buffalo Bisons at Syracuse Mets | Ppd. |
| April 17, 2025 | L | Buffalo Bisons 0 at Syracuse Mets 2 | Final |
| April 18, 2025 | L | Buffalo Bisons 0 at Syracuse Mets 3 (Game 1) | Final (7) |
| April 18, 2025 | L | Buffalo Bisons 5 at Syracuse Mets 11 (Game 2) | Final (7) |
| April 19, 2025 | W | Buffalo Bisons 5 at Syracuse Mets 1 | Final |
| April 20, 2025 | L | Buffalo Bisons 1 at Syracuse Mets 2 | Final |
| April 22, 2025 | L | Rochester Red Wings 8 at Buffalo Bisons 4 | Final (11) |
| April 23, 2025 | W | Rochester Red Wings 3 at Buffalo Bisons 6 (Game 1) | Final (7) |
| April 23, 2025 | W | Rochester Red Wings 2 at Buffalo Bisons 3 (Game 2) | Final (7) |
| April 24, 2025 | W | Rochester Red Wings 1 at Buffalo Bisons 8 | Final |
| April 25, 2025 | L | Rochester Red Wings 8 at Buffalo Bisons 1 | Final |
| April 26, 2025 | W | Rochester Red Wings 3 at Buffalo Bisons 4 | Final |
| April 27, 2025 | W | Rochester Red Wings 0 at Buffalo Bisons 2 | Final |
| April 29, 2025 | L | Buffalo Bisons 1 at Iowa Cubs 9 | Final |
| April 30, 2025 | W | Buffalo Bisons 10 at Iowa Cubs 8 | Final |
| May 1, 2025 | W | Buffalo Bisons 8 at Iowa Cubs 1 | Final |
| May 2, 2025 | L | Buffalo Bisons 2 at Iowa Cubs 4 | Final |
| May 3, 2025 | L | Buffalo Bisons 2 at Iowa Cubs 10 | Final |
| May 4, 2025 | W | Buffalo Bisons 3 at Iowa Cubs 1 | Final |
| May 6, 2025 | L | Buffalo Bisons 2 at St. Paul Saints 6 | Final |
| May 7, 2025 | L | Buffalo Bisons 7 at St. Paul Saints 8 | Final |
| May 8, 2025 | L | Buffalo Bisons 10 at St. Paul Saints 13 | Final |
| May 9, 2025 | W | Buffalo Bisons 17 at St. Paul Saints 3 | Final |
| May 10, 2025 | L | Buffalo Bisons 1 at St. Paul Saints 2 | Final |
| May 11, 2025 | L | Buffalo Bisons 2 at St. Paul Saints 3 | Final |
| May 13, 2025 | L | Worcester Red Sox 10 at Buffalo Bisons 7 | Final |
| May 14, 2025 | L | Worcester Red Sox 8 at Buffalo Bisons 4 | Final |
| May 15, 2025 | W | Worcester Red Sox 1 at Buffalo Bisons 12 | Final |
| May 16, 2025 | L | Worcester Red Sox 10 at Buffalo Bisons 3 | Final |
| May 17, 2025 | W | Worcester Red Sox 5 at Buffalo Bisons 6 | Final |
| May 18, 2025 | W | Worcester Red Sox 4 at Buffalo Bisons 8 | Final |
| May 20, 2025 | L | Buffalo Bisons 4 at Lehigh Valley IronPigs 5 | Final |
| May 21, 2025 | L | Buffalo Bisons 5 at Lehigh Valley IronPigs 8 | Final (8) |
| May 22, 2025 | | Buffalo Bisons at Lehigh Valley IronPigs | Ppd. |
| May 23, 2025 | W | Buffalo Bisons 14 at Lehigh Valley IronPigs 6 | Final |
| May 24, 2025 | L | Buffalo Bisons 1 at Lehigh Valley IronPigs 4 (Game 1) | Final (7) |
| May 24, 2025 | L | Buffalo Bisons 2 at Lehigh Valley IronPigs 4 (Game 2) | Final (7) |
| May 25, 2025 | L | Buffalo Bisons 2 at Lehigh Valley IronPigs 7 | Final |
| May 27, 2025 | W | Charlotte Knights 9 at Buffalo Bisons 10 | Final |
| May 28, 2025 | | Charlotte Knights at Buffalo Bisons | Ppd. |
| May 29, 2025 | W | Charlotte Knights 2 at Buffalo Bisons 3 (Game 1) | Final (7) |
| May 29, 2025 | W | Charlotte Knights 2 at Buffalo Bisons 5 (Game 2) | Final (7) |
| May 30, 2025 | L | Charlotte Knights 5 at Buffalo Bisons 3 | Final |
| May 31, 2025 | W | Charlotte Knights 4 at Buffalo Bisons 5 | Final |
| June 1, 2025 | L | Charlotte Knights 8 at Buffalo Bisons 4 | Final |
| June 3, 2025 | W | Buffalo Bisons 8 at Syracuse Mets 5 | Final |
| June 4, 2025 | L | Buffalo Bisons 6 at Syracuse Mets 7 | Final |
| June 5, 2025 | W | Buffalo Bisons 9 at Syracuse Mets 1 | Final |
| June 6, 2025 | L | Buffalo Bisons 0 at Syracuse Mets 18 | Final |
| June 7, 2025 | W | Buffalo Bisons 7 at Syracuse Mets 5 | Final |
| June 8, 2025 | W | Buffalo Bisons 8 at Syracuse Mets 6 | Final (10) |
| June 10, 2025 | L | Columbus Clippers 4 at Buffalo Bisons 3 | Final |
| June 11, 2025 | W | Columbus Clippers 2 at Buffalo Bisons 5 | Final |
| June 12, 2025 | L | Columbus Clippers 7 at Buffalo Bisons 1 | Final |
| June 13, 2025 | W | Columbus Clippers 5 at Buffalo Bisons 6 | Final |
| June 14, 2025 | L | Columbus Clippers 6 at Buffalo Bisons 1 | Final |
| June 15, 2025 | L | Columbus Clippers 7 at Buffalo Bisons 3 | Final (10) |
| June 17, 2025 | L | Buffalo Bisons 4 at Worcester Red Sox 5 | Final |
| June 18, 2025 | W | Buffalo Bisons 14 at Worcester Red Sox 1 | Final |
| June 19, 2025 | L | Buffalo Bisons 4 at Worcester Red Sox 9 | Final |
| June 20, 2025 | L | Buffalo Bisons 1 at Worcester Red Sox 7 | Final |
| June 21, 2025 | W | Buffalo Bisons 10 at Worcester Red Sox 6 | Final |
| June 22, 2025 | L | Buffalo Bisons 10 at Worcester Red Sox 12 | Final |
| June 24, 2025 | L | Lehigh Valley IronPigs 4 at Buffalo Bisons 1 | Final (10) |
| June 25, 2025 | L | Lehigh Valley IronPigs 7 at Buffalo Bisons 1 | Final |
| June 26, 2025 | L | Lehigh Valley IronPigs 12 at Buffalo Bisons 8 | Final |
| June 27, 2025 | L | Lehigh Valley IronPigs 8 at Buffalo Bisons 3 | Final |
| June 28, 2025 | W | Lehigh Valley IronPigs 3 at Buffalo Bisons 13 | Final |
| June 29, 2025 | W | Lehigh Valley IronPigs 3 at Buffalo Bisons 4 | Final (11) |
| July 1, 2025 | W | Rochester Red Wings 1 at Buffalo Bisons 2 | Final |
| July 2, 2025 | W | Rochester Red Wings 3 at Buffalo Bisons 5 | Final |
| July 3, 2025 | L | Rochester Red Wings 14 at Buffalo Bisons 8 | Final |
| July 4, 2025 | W | Buffalo Bisons 9 at Rochester Red Wings 6 | Final |
| July 5, 2025 | L | Buffalo Bisons 5 at Rochester Red Wings 8 | Final |
| July 6, 2025 | L | Buffalo Bisons 1 at Rochester Red Wings 3 | Final |
| July 8, 2025 | L | Buffalo Bisons 2 at Scranton/Wilkes-Barre RailRiders 5 | Final |
| July 9, 2025 | L | Buffalo Bisons 2 at Scranton/Wilkes-Barre RailRiders 7 | Final |
| July 10, 2025 | L | Buffalo Bisons 7 at Scranton/Wilkes-Barre RailRiders 11 | Final |
| July 11, 2025 | L | Buffalo Bisons 1 at Scranton/Wilkes-Barre RailRiders 10 | Final |
| July 12, 2025 | L | Buffalo Bisons 3 at Scranton/Wilkes-Barre RailRiders 6 | Final |
| July 13, 2025 | L | Buffalo Bisons 4 at Scranton/Wilkes-Barre RailRiders 5 | Final |
| July 18, 2025 | L | Omaha Storm Chasers 7 at Buffalo Bisons 3 | Final |
| July 19, 2025 | W | Omaha Storm Chasers 2 at Buffalo Bisons 3 | Final |
| July 20, 2025 | L | Omaha Storm Chasers 8 at Buffalo Bisons 6 | Final |
| July 22, 2025 | W | Buffalo Bisons 3 at Columbus Clippers 1 | Final |
| July 23, 2025 | L | Buffalo Bisons 4 at Columbus Clippers 6 | Final |
| July 24, 2025 | W | Buffalo Bisons 7 at Columbus Clippers 1 | Final |
| July 25, 2025 | W | Buffalo Bisons 10 at Columbus Clippers 3 | Final |
| July 26, 2025 | | Buffalo Bisons at Columbus Clippers | Susp. |
| July 27, 2025 | | Buffalo Bisons at Columbus Clippers (Game 2) | Cancelled |
| July 27, 2025 | | Buffalo Bisons at Columbus Clippers (Game 1) | Ppd. |
| July 29, 2025 | W | Syracuse Mets 0 at Buffalo Bisons 1 | Final |
| July 30, 2025 | L | Syracuse Mets 8 at Buffalo Bisons 3 | Final |
| July 31, 2025 | L | Syracuse Mets 2 at Buffalo Bisons 1 | Final |
| August 1, 2025 | L | Syracuse Mets 5 at Buffalo Bisons 3 | Final |
| August 2, 2025 | L | Syracuse Mets 5 at Buffalo Bisons 4 | Final |
| August 3, 2025 | L | Syracuse Mets 4 at Buffalo Bisons 3 | Final |
| August 5, 2025 | L | Buffalo Bisons 6 at Worcester Red Sox 10 | Final |
| August 6, 2025 | W | Buffalo Bisons 7 at Worcester Red Sox 3 | Final |
| August 7, 2025 | L | Buffalo Bisons 1 at Worcester Red Sox 2 | Final |
| August 8, 2025 | L | Buffalo Bisons 2 at Worcester Red Sox 5 | Final |
| August 9, 2025 | W | Buffalo Bisons 5 at Worcester Red Sox 3 | Final |
| August 10, 2025 | W | Buffalo Bisons 6 at Worcester Red Sox 3 | Final |
| August 12, 2025 | W | Lehigh Valley IronPigs 0 at Buffalo Bisons 6 | Final |
| August 13, 2025 | L | Lehigh Valley IronPigs 9 at Buffalo Bisons 4 | Final |
| August 14, 2025 | W | Lehigh Valley IronPigs 5 at Buffalo Bisons 10 | Final |
| August 15, 2025 | W | Lehigh Valley IronPigs 0 at Buffalo Bisons 2 | Final |
| August 16, 2025 | L | Lehigh Valley IronPigs 10 at Buffalo Bisons 3 | Final |
| August 17, 2025 | W | Lehigh Valley IronPigs 4 at Buffalo Bisons 5 | Final |
| August 19, 2025 | | Scranton/Wilkes-Barre RailRiders at Buffalo Bisons | Ppd. |
| August 20, 2025 | W | Scranton/Wilkes-Barre RailRiders 1 at Buffalo Bisons 4 | Final |
| August 21, 2025 | L | Scranton/Wilkes-Barre RailRiders 5 at Buffalo Bisons 3 (Game 1) | Final (7) |
| August 21, 2025 | W | Scranton/Wilkes-Barre RailRiders 3 at Buffalo Bisons 4 (Game 2) | Final |
| August 22, 2025 | L | Scranton/Wilkes-Barre RailRiders 7 at Buffalo Bisons 4 | Final |
| August 23, 2025 | L | Scranton/Wilkes-Barre RailRiders 10 at Buffalo Bisons 3 | Final |
| August 24, 2025 | L | Scranton/Wilkes-Barre RailRiders 5 at Buffalo Bisons 3 | Final |
| August 26, 2025 | W | Buffalo Bisons 5 at Indianapolis Indians 4 | Final |
| August 27, 2025 | W | Buffalo Bisons 6 at Indianapolis Indians 3 | Final |
| August 28, 2025 | W | Buffalo Bisons 5 at Indianapolis Indians 3 | Final |
| August 29, 2025 | L | Buffalo Bisons 3 at Indianapolis Indians 5 | Final |
| August 30, 2025 | L | Buffalo Bisons 1 at Indianapolis Indians 2 | Final |
| August 31, 2025 | W | Buffalo Bisons 6 at Indianapolis Indians 2 | Final |
| September 2, 2025 | W | Syracuse Mets 3 at Buffalo Bisons 4 | Final |
| September 3, 2025 | L | Syracuse Mets 10 at Buffalo Bisons 2 | Final |
| September 4, 2025 | | Syracuse Mets at Buffalo Bisons | Ppd. |
| September 5, 2025 | W | Syracuse Mets 1 at Buffalo Bisons 5 (Game 1) | Final (7) |
| September 5, 2025 | L | Syracuse Mets 7 at Buffalo Bisons 1 (Game 2) | Final (7) |
| September 6, 2025 | L | Syracuse Mets 10 at Buffalo Bisons 0 | Final |
| September 7, 2025 | W | Syracuse Mets 6 at Buffalo Bisons 10 | Final |
| September 9, 2025 | L | Buffalo Bisons 4 at Rochester Red Wings 5 | Final (10) |
| September 10, 2025 | W | Buffalo Bisons 9 at Rochester Red Wings 2 | Final |
| September 11, 2025 | L | Buffalo Bisons 7 at Rochester Red Wings 8 | Final |
| September 12, 2025 | W | Buffalo Bisons 4 at Rochester Red Wings 3 | Final |
| September 13, 2025 | W | Buffalo Bisons 4 at Rochester Red Wings 3 | Final |
| September 14, 2025 | L | Buffalo Bisons 4 at Rochester Red Wings 5 | Final |
| September 16, 2025 | | Scranton/Wilkes-Barre RailRiders at Buffalo Bisons | 6:05 p.m. |
| September 17, 2025 | | Scranton/Wilkes-Barre RailRiders at Buffalo Bisons | 6:05 p.m. |
| September 18, 2025 | | Scranton/Wilkes-Barre RailRiders at Buffalo Bisons | 1:05 p.m. |
| September 19, 2025 | | Scranton/Wilkes-Barre RailRiders at Buffalo Bisons | 6:05 p.m. |
| September 20, 2025 | | Scranton/Wilkes-Barre RailRiders at Buffalo Bisons | 1:05 p.m. |
| September 21, 2025 | | Scranton/Wilkes-Barre RailRiders at Buffalo Bisons | 12:05 p.m. |
Buffalo Bisons Schedule
