| | | |
| February 8, 2021 | W | Binghamton Devils 4 at Wilkes-Barre/Scranton Penguins 3 | Final (OT) |
| February 10, 2021 | W | Lehigh Valley Phantoms 1 at Binghamton Devils 2 | Final (OT) |
| February 13, 2021 | L | Utica Comets 6 at Binghamton Devils 5 | Final (SO) |
| February 17, 2021 | L | Hershey Bears 2 at Binghamton Devils 1 | Final |
| February 20, 2021 | L | Binghamton Devils 0 at Lehigh Valley Phantoms 3 | Final |
| February 24, 2021 | L | Lehigh Valley Phantoms 5 at Binghamton Devils 4 | Final (OT) |
| February 26, 2021 | L | Hershey Bears 6 at Binghamton Devils 3 | Final |
| February 27, 2021 | L | Binghamton Devils 0 at Hershey Bears 3 | Final |
| March 6, 2021 | L | Wilkes-Barre/Scranton Penguins 6 at Binghamton Devils 3 | Final |
| March 7, 2021 | L | Binghamton Devils 3 at Hershey Bears 4 | Final (OT) |
| March 10, 2021 | | Lehigh Valley Phantoms 1 at Binghamton Devils 1 | Susp. |
| March 17, 2021 | | Binghamton Devils at Lehigh Valley Phantoms | Ppd. |
| March 19, 2021 | W | Hershey Bears 5 at Binghamton Devils 6 | Final |
| March 21, 2021 | L | Binghamton Devils 2 at Hershey Bears 3 | Final (OT) |
| March 26, 2021 | L | Lehigh Valley Phantoms 3 at Binghamton Devils 2 | Final |
| March 27, 2021 | L | Binghamton Devils 3 at Lehigh Valley Phantoms 6 | Final |
| March 31, 2021 | L | Wilkes-Barre/Scranton Penguins 3 at Binghamton Devils 2 | Final (OT) |
| April 3, 2021 | L | Binghamton Devils 2 at Hershey Bears 4 | Final |
| April 5, 2021 | W | Lehigh Valley Phantoms 1 at Binghamton Devils 2 | Final (SO) |
| April 7, 2021 | L | Hershey Bears 3 at Binghamton Devils 2 | Final |
| April 10, 2021 | L | Binghamton Devils 4 at Wilkes-Barre/Scranton Penguins 5 | Final (OT) |
| April 11, 2021 | | Binghamton Devils at Lehigh Valley Phantoms | Ppd. |
| April 17, 2021 | L | Binghamton Devils 3 at Hershey Bears 6 | Final |
| April 21, 2021 | L | Binghamton Devils 0 at Utica Comets 3 | Final |
| April 23, 2021 | L | Lehigh Valley Phantoms 4 at Binghamton Devils 2 | Final |
| April 24, 2021 | L | Binghamton Devils 2 at Lehigh Valley Phantoms 3 | Final |
| April 26, 2021 | L | Lehigh Valley Phantoms 6 at Binghamton Devils 5 | Final |
| April 28, 2021 | L | Hershey Bears 4 at Binghamton Devils 3 | Final (SO) |
| April 30, 2021 | L | Wilkes-Barre/Scranton Penguins 3 at Binghamton Devils 1 | Final |
| May 1, 2021 | W | Binghamton Devils 4 at Lehigh Valley Phantoms 2 | Final |
| May 5, 2021 | L | Binghamton Devils 3 at Wilkes-Barre/Scranton Penguins 6 | Final |
| May 7, 2021 | L | Hershey Bears 2 at Binghamton Devils 1 | Final |
| May 8, 2021 | L | Binghamton Devils 1 at Wilkes-Barre/Scranton Penguins 4 | Final |
| May 12, 2021 | L | Lehigh Valley Phantoms 2 at Binghamton Devils 1 | Final |
| May 15, 2021 | L | Binghamton Devils 2 at Hershey Bears 3 | Final |
| May 16, 2021 | W | Binghamton Devils 4 at Lehigh Valley Phantoms 3 | Final (SO) |
Binghamton Devils Schedule
