| | | |
| March 9, 2025 | T | Philadelphia Union II 0 at New England Revolution II 0 | Final (PK 3-4) |
| March 13, 2025 | W | FC Cincinnati 2 0 at New England Revolution II 2 | Final |
| March 28, 2025 | W | Toronto FC II 0 at New England Revolution II 4 | Final |
| April 9, 2025 | L | New England Revolution II 0 at Orlando City B 1 | Final |
| April 23, 2025 | T | Columbus Crew 2 2 at New England Revolution II 2 | Final (PK 1-4) |
| April 26, 2025 | W | New York City FC II 1 at New England Revolution II 2 | Final |
| May 4, 2025 | T | New England Revolution II 3 at Toronto FC II 3 | Final (PK 9-8) |
| May 18, 2025 | L | New England Revolution II 1 at New York Red Bulls II 4 | Final |
| May 24, 2025 | L | New England Revolution II 0 at Chattanooga FC 1 | Final |
| May 31, 2025 | W | New England Revolution II 1 at New York City FC II 0 | Final |
| June 9, 2025 | T | New England Revolution II 2 at Chicago Fire FC II 2 | Final (PK 5-4) |
| June 15, 2025 | L | FC Cincinnati 2 1 at New England Revolution II 0 | Final |
| June 26, 2025 | T | New England Revolution II 2 at Philadelphia Union II 2 | Final (PK 6-7) |
| June 29, 2025 | | Huntsville City Football Club at New England Revolution II | Ppd. |
| July 5, 2025 | W | New England Revolution II 2 at Columbus Crew 2 1 | Final |
| July 13, 2025 | W | New England Revolution II 4 at Chicago Fire FC II 3 | Final |
| July 20, 2025 | W | Orlando City B 0 at New England Revolution II 3 | Final |
| July 30, 2025 | W | Atlanta United 2 0 at New England Revolution II 3 | Final |
| August 2, 2025 | L | New England Revolution II 0 at Carolina Core FC 1 | Final |
| August 10, 2025 | T | Columbus Crew 2 2 at New England Revolution II 2 | Final (PK 4-5) |
| August 15, 2025 | W | New York Red Bulls II 2 at New England Revolution II 4 | Final |
| August 24, 2025 | W | New England Revolution II 3 at Philadelphia Union II 1 | Final |
| August 31, 2025 | T | Chicago Fire FC II 2 at New England Revolution II 2 | Final (PK 3-1) |
| September 8, 2025 | W | Huntsville City Football Club 0 at New England Revolution II 1 | Final |
| September 12, 2025 | W | Toronto FC II 1 at New England Revolution II 2 | Final |
| September 18, 2025 | W | New England Revolution II 3 at New York City FC II 1 | Final |
| September 21, 2025 | L | New England Revolution II 1 at FC Cincinnati 2 3 | Final |
| September 26, 2025 | L | Crown Legacy FC 1 at New England Revolution II 0 | Final |
| October 5, 2025 | W | New England Revolution II 5 at Inter Miami CF II 2 | Final |
| October 19, 2025 | L | Chicago Fire FC II 1 at New England Revolution II 0 (Playoff) | Final |
New England Revolution II Schedule
