| | | |
| March 9, 2025 | T | Philadelphia Union II 0 at New England Revolution II 0 | Final (PK 3-4) |
| March 13, 2025 | W | FC Cincinnati 2 0 at New England Revolution II 2 | Final |
| March 28, 2025 | W | Toronto FC II 0 at New England Revolution II 4 | Final |
| April 9, 2025 | L | New England Revolution II 0 at Orlando City B 1 | Final |
| April 23, 2025 | T | Columbus Crew 2 2 at New England Revolution II 2 | Final (PK 1-4) |
| April 26, 2025 | W | New York City FC II 1 at New England Revolution II 2 | Final |
| May 4, 2025 | T | New England Revolution II 3 at Toronto FC II 3 | Final (PK 9-8) |
| May 18, 2025 | | New England Revolution II at New York Red Bulls II | 5:00 p.m. |
| May 24, 2025 | | New England Revolution II at Chattanooga FC | 7:00 p.m. |
| May 31, 2025 | | New England Revolution II at New York City FC II | 4:00 p.m. |
| June 8, 2025 | | New England Revolution II at Chicago Fire FC II | 4:00 p.m. |
| June 15, 2025 | | FC Cincinnati 2 at New England Revolution II | 3:00 p.m. |
| June 26, 2025 | | New England Revolution II at Philadelphia Union II | 7:00 p.m. |
| June 29, 2025 | | Huntsville City Football Club at New England Revolution II | 3:00 p.m. |
| July 5, 2025 | | New England Revolution II at Columbus Crew 2 | 3:00 p.m. |
| July 13, 2025 | | New England Revolution II at Chicago Fire FC II | 2:00 p.m. |
| July 20, 2025 | | Orlando City B at New England Revolution II | 3:00 p.m. |
| July 30, 2025 | | Atlanta United 2 at New England Revolution II | 11:00 a.m. |
| August 2, 2025 | | New England Revolution II at Carolina Core FC | 7:30 p.m. |
| August 10, 2025 | | Columbus Crew 2 at New England Revolution II | 8:00 p.m. |
| August 15, 2025 | | New York Red Bulls II at New England Revolution II | 5:00 p.m. |
| August 24, 2025 | | New England Revolution II at Philadelphia Union II | 3:00 p.m. |
| August 31, 2025 | | Chicago Fire FC II at New England Revolution II | 3:00 p.m. |
| September 12, 2025 | | Toronto FC II at New England Revolution II | 3:00 p.m. |
| September 18, 2025 | | New England Revolution II at New York City FC II | 7:30 p.m. |
| September 21, 2025 | | New England Revolution II at FC Cincinnati 2 | 6:00 p.m. |
| September 26, 2025 | | Crown Legacy FC at New England Revolution II | 3:00 p.m. |
| October 5, 2025 | | New England Revolution II at Inter Miami CF II | 1:00 p.m. |
New England Revolution II Schedule
