| | | |
| March 8, 2025 | T | Colorado Springs Switchbacks FC 2 at El Paso Locomotive FC 2 | Final |
| March 15, 2025 | T | Phoenix Rising FC 4 at El Paso Locomotive FC 4 | Final |
| March 22, 2025 | L | El Paso Locomotive FC 0 at New Mexico United 1 | Final |
| March 29, 2025 | W | El Paso Locomotive FC 2 at Hartford Athletic 1 | Final |
| April 5, 2025 | W | Lexington Sporting Club 1 at El Paso Locomotive FC 2 | Final |
| April 13, 2025 | L | El Paso Locomotive FC 1 at Birmingham Legion FC 3 | Final |
| April 19, 2025 | T | El Paso Locomotive FC 1 at Colorado Springs Switchbacks FC 1 | Final |
| April 26, 2025 | T | El Paso Locomotive FC 0 at Texoma FC 0 (Jagermeister Cup) | Final |
| May 3, 2025 | W | New Mexico United 0 at El Paso Locomotive FC 3 | Final |
| May 10, 2025 | T | El Paso Locomotive FC 1 at FC Tulsa 1 | Final |
| May 16, 2025 | W | Indy Eleven 1 at El Paso Locomotive FC 3 | Final |
| May 24, 2025 | W | El Paso Locomotive FC 2 at Las Vegas Lights FC 1 | Final |
| May 31, 2025 | L | Colorado Springs Switchbacks FC 1 at El Paso Locomotive FC 0 | Final |
| June 7, 2025 | T | El Paso Locomotive FC 0 at Oakland Roots 0 | Final |
| June 14, 2025 | L | Orange County SC 3 at El Paso Locomotive FC 0 | Final |
| June 21, 2025 | W | El Paso Locomotive FC 2 at Monterey Bay FC 1 | Final |
| July 4, 2025 | L | San Antonio FC 2 at El Paso Locomotive FC 1 | Final |
| July 12, 2025 | L | El Paso Locomotive FC 0 at Sacramento Republic FC 3 | Final |
| July 19, 2025 | T | Phoenix Rising FC 2 at El Paso Locomotive FC 2 (Jagermeister Cup) | Final |
| July 26, 2025 | W | El Paso Locomotive FC 1 at Union Omaha 0 (Jagermeister Cup) | Final |
| August 2, 2025 | W | Las Vegas Lights FC 0 at El Paso Locomotive FC 6 | Final |
| August 9, 2025 | T | El Paso Locomotive FC 0 at Miami FC 0 | Final |
| August 16, 2025 | T | Monterey Bay FC 2 at El Paso Locomotive FC 2 | Final |
| August 23, 2025 | W | Sacramento Republic FC 0 at El Paso Locomotive FC 1 | Final |
| August 30, 2025 | T | El Paso Locomotive FC 3 at Phoenix Rising FC 3 | Final |
| September 6, 2025 | L | Loudoun United FC 2 at El Paso Locomotive FC 1 | Final |
| September 12, 2025 | L | El Paso Locomotive FC 0 at North Carolina FC 1 | Final |
| September 20, 2025 | L | Charleston Battery 2 at El Paso Locomotive FC 0 | Final |
| September 26, 2025 | T | Rhode Island FC 2 at El Paso Locomotive FC 2 | Final |
| October 1, 2025 | W | Oakland Roots 1 at El Paso Locomotive FC 3 | Final |
| October 4, 2025 | T | El Paso Locomotive FC 0 at Orange County SC 0 | Final |
| October 11, 2025 | W | El Paso Locomotive FC 2 at Lexington Sporting Club 1 | Final |
| October 18, 2025 | T | FC Tulsa 1 at El Paso Locomotive FC 1 | Final |
| October 25, 2025 | L | El Paso Locomotive FC 2 at San Antonio FC 5 | Final |
| November 1, 2025 | L | Phoenix Rising FC 1 at El Paso Locomotive FC 0 (Playoff) | Final |
El Paso Locomotive FC Schedule
