| | | |
| March 8, 2025 | W | Monterey Bay FC 0 at San Antonio FC 1 | Final |
| March 15, 2025 | W | Pittsburgh Riverhounds SC 0 at San Antonio FC 2 | Final |
| March 22, 2025 | W | San Antonio FC 2 at Oakland Roots 1 | Final |
| March 29, 2025 | W | San Antonio FC 3 at Lexington Sporting Club 2 | Final |
| April 6, 2025 | L | Phoenix Rising FC 2 at San Antonio FC 1 | Final |
| April 12, 2025 | L | Miami FC 2 at San Antonio FC 1 | Final |
| April 23, 2025 | W | Colorado Springs Switchbacks FC 2 at San Antonio FC 3 | Final |
| April 26, 2025 | W | San Antonio FC 1 at Phoenix Rising FC 0 (Jagermeister Cup) | Final |
| May 3, 2025 | T | San Antonio FC 0 at Rhode Island FC 0 | Final |
| May 10, 2025 | L | Oakland Roots 2 at San Antonio FC 1 | Final |
| May 17, 2025 | L | San Antonio FC 0 at Charleston Battery 4 | Final |
| May 28, 2025 | T | FC Tulsa 1 at San Antonio FC 1 | Final |
| June 7, 2025 | W | Las Vegas Lights FC 0 at San Antonio FC 3 | Final |
| June 14, 2025 | T | San Antonio FC 0 at Sacramento Republic FC 0 | Final |
| June 21, 2025 | | San Antonio FC at New Mexico United | 9:00 p.m. |
| June 25, 2025 | | San Antonio FC at Colorado Springs Switchbacks FC | 9:00 p.m. |
| June 28, 2025 | | Union Omaha at San Antonio FC | 9:00 p.m. |
| July 4, 2025 | | San Antonio FC at El Paso Locomotive FC | 9:00 p.m. |
| July 12, 2025 | | Tampa Bay Rowdies at San Antonio FC | 9:00 p.m. |
| July 26, 2025 | | New Mexico United at San Antonio FC | 9:00 p.m. |
| August 2, 2025 | | Sacramento Republic FC at San Antonio FC | 9:00 p.m. |
| August 9, 2025 | | San Antonio FC at Las Vegas Lights FC | 10:30 p.m. |
| August 16, 2025 | | Lexington Sporting Club at San Antonio FC | 9:00 p.m. |
| August 20, 2025 | | San Antonio FC at Orange County SC | 10:00 p.m. |
| August 23, 2025 | | San Antonio FC at Monterey Bay FC | 10:00 p.m. |
| August 30, 2025 | | San Antonio FC at Detroit City FC | 7:00 p.m. |
| September 6, 2025 | | New Mexico United at San Antonio FC | 8:30 p.m. |
| September 13, 2025 | | San Antonio FC at Loudoun United FC | 6:00 p.m. |
| September 20, 2025 | | Orange County SC at San Antonio FC | 8:30 p.m. |
| September 27, 2025 | | Birmingham Legion FC at San Antonio FC | 8:30 p.m. |
| October 4, 2025 | | San Antonio FC at Colorado Springs Switchbacks FC | 8:00 p.m. |
| October 11, 2025 | | San Antonio FC at FC Tulsa | 8:00 p.m. |
| October 18, 2025 | | San Antonio FC at Phoenix Rising FC | 10:00 p.m. |
| October 25, 2025 | | El Paso Locomotive FC at San Antonio FC | 8:30 p.m. |
San Antonio FC Schedule
