| | | |
| May 16, 2025 | W | Calgary Surge 94 at Niagara River Lions 98 | Final |
| May 18, 2025 | W | Niagara River Lions 87 at Ottawa BlackJacks 85 | Final |
| May 22, 2025 | L | Niagara River Lions 72 at Vancouver Bandits 109 | Final |
| May 24, 2025 | W | Niagara River Lions 88 at Saskatchewan Rattlers 86 | Final |
| May 30, 2025 | L | Saskatchewan Rattlers 89 at Niagara River Lions 87 | Final |
| June 6, 2025 | W | Scarborough Shooting Stars 94 at Niagara River Lions 98 | Final |
| June 8, 2025 | W | Brampton Honey Badgers 80 at Niagara River Lions 94 | Final |
| June 13, 2025 | L | Edmonton Stingers 106 at Niagara River Lions 88 | Final |
| June 15, 2025 | W | Niagara River Lions 90 at Ottawa BlackJacks 89 | Final |
| June 20, 2025 | W | Montreal Alliance 82 at Niagara River Lions 93 | Final |
| June 22, 2025 | L | Niagara River Lions 70 at Scarborough Shooting Stars 102 | Final |
| June 29, 2025 | L | Niagara River Lions 66 at Brampton Honey Badgers 91 | Final |
| July 4, 2025 | W | Winnipeg Sea Bears 82 at Niagara River Lions 93 | Final |
| July 6, 2025 | W | Niagara River Lions 77 at Montreal Alliance 73 | Final |
| July 10, 2025 | W | Vancouver Bandits 77 at Niagara River Lions 96 | Final |
| July 16, 2025 | W | Brampton Honey Badgers 79 at Niagara River Lions 97 | Final |
| July 20, 2025 | W | Scarborough Shooting Stars 81 at Niagara River Lions 96 | Final |
| July 25, 2025 | W | Montreal Alliance 89 at Niagara River Lions 91 | Final |
| July 27, 2025 | W | Niagara River Lions 86 at Brampton Honey Badgers 84 | Final |
| July 31, 2025 | L | Ottawa BlackJacks 96 at Niagara River Lions 93 | Final |
| August 3, 2025 | L | Niagara River Lions 64 at Scarborough Shooting Stars 81 | Final |
| August 6, 2025 | | Niagara River Lions at Winnipeg Sea Bears | 7:00 p.m. |
| August 8, 2025 | | Niagara River Lions at Edmonton Stingers | 8:00 p.m. |
| August 10, 2025 | | Niagara River Lions at Calgary Surge | 7:00 p.m. |
Niagara River Lions Schedule
