| | | |
| March 31, 2025 | L | Vegas Knight Hawks 48 at San Diego Strike Force 41 | Final |
| April 6, 2025 | L | San Diego Strike Force 18 at Bay Area Panthers 41 | Final |
| April 11, 2025 | W | San Diego Strike Force 35 at Vegas Knight Hawks 27 | Final |
| April 27, 2025 | W | Tucson Sugar Skulls 22 at San Diego Strike Force 45 | Final |
| May 4, 2025 | L | San Diego Strike Force 34 at Bay Area Panthers 57 | Final |
| May 11, 2025 | W | Northern Arizona Wranglers 29 at San Diego Strike Force 40 | Final |
| May 17, 2025 | L | San Diego Strike Force 48 at San Antonio Gunslingers 49 | Final (OT) |
| May 25, 2025 | W | Vegas Knight Hawks 39 at San Diego Strike Force 42 | Final |
| May 31, 2025 | W | Northern Arizona Wranglers 32 at San Diego Strike Force 35 | Final |
| June 7, 2025 | W | San Diego Strike Force 58 at Tucson Sugar Skulls 42 | Final |
| June 14, 2025 | W | San Diego Strike Force 56 at Northern Arizona Wranglers 53 | Final |
| June 22, 2025 | W | San Antonio Gunslingers 49 at San Diego Strike Force 53 | Final |
| July 7, 2025 | W | Bay Area Panthers 38 at San Diego Strike Force 46 | Final |
| July 12, 2025 | L | San Diego Strike Force 43 at Arizona Rattlers 46 | Final |
| July 19, 2025 | L | San Diego Strike Force 40 at Fishers Freight 49 | Final |
| July 27, 2025 | W | Arizona Rattlers 26 at San Diego Strike Force 46 | Final |
| August 4, 2025 | | San Diego Strike Force at Arizona Rattlers (Playoff) | 10:05 p.m. |
San Diego Strike Force Schedule
