Louisville Xtreme Schedule
All times Eastern
Complete Schedule
| April 24, 2021 | L | Massachusetts Pirates 49 at Louisville Xtreme 18 | Final |
| May 7, 2021 | L | Louisville Xtreme 29 at Green Bay Blizzard 49 | Final |
| May 22, 2021 | L | Frisco Fighters 34 at Louisville Xtreme 26 | Final |
| May 29, 2021 | L | Sioux Falls Storm 49 at Louisville Xtreme 43 | Final |
| June 5, 2021 | L | Louisville Xtreme 37 at Massachusetts Pirates 42 | Final |
| June 12, 2021 | Green Bay Blizzard at Louisville Xtreme | Cancelled | |
| June 19, 2021 | Louisville Xtreme at Frisco Fighters | Cancelled | |
| June 27, 2021 | Massachusetts Pirates at Louisville Xtreme | Cancelled | |
| July 3, 2021 | Spokane Shock at Louisville Xtreme | Cancelled | |
| July 10, 2021 | Green Bay Blizzard at Louisville Xtreme | Cancelled | |
| July 17, 2021 | Louisville Xtreme at Iowa Barnstormers | Cancelled | |
| July 24, 2021 | Louisville Xtreme at Massachusetts Pirates | Cancelled | |
| July 31, 2021 | Iowa Barnstormers at Louisville Xtreme | Cancelled | |
| August 7, 2021 | Louisville Xtreme at Sioux Falls Storm | Cancelled |
