| | | |
| April 4, 2025 | W | Delmarva Shorebirds 1 at Salem Red Sox 12 | Final |
| April 5, 2025 | W | Delmarva Shorebirds 2 at Salem Red Sox 4 | Final |
| April 6, 2025 | W | Delmarva Shorebirds 5 at Salem Red Sox 6 | Final |
| April 8, 2025 | L | Salem Red Sox 8 at Fredericksburg Nationals 9 | Final |
| April 9, 2025 | W | Salem Red Sox 6 at Fredericksburg Nationals 2 | Final |
| April 10, 2025 | L | Salem Red Sox 4 at Fredericksburg Nationals 7 | Final |
| April 11, 2025 | | Salem Red Sox at Fredericksburg Nationals | Ppd. |
| April 12, 2025 | L | Salem Red Sox 0 at Fredericksburg Nationals 3 (Game 1) | Final (7) |
| April 12, 2025 | L | Salem Red Sox 2 at Fredericksburg Nationals 5 (Game 2) | Final (7) |
| April 13, 2025 | L | Salem Red Sox 4 at Fredericksburg Nationals 5 | Final |
| April 15, 2025 | L | Lynchburg Hillcats 10 at Salem Red Sox 8 | Final |
| April 16, 2025 | W | Lynchburg Hillcats 7 at Salem Red Sox 9 | Final |
| April 17, 2025 | L | Lynchburg Hillcats 4 at Salem Red Sox 1 | Final |
| April 18, 2025 | L | Lynchburg Hillcats 5 at Salem Red Sox 2 | Final |
| April 19, 2025 | L | Lynchburg Hillcats 13 at Salem Red Sox 4 | Final |
| April 20, 2025 | L | Lynchburg Hillcats 5 at Salem Red Sox 2 | Final |
| April 22, 2025 | W | Salem Red Sox 12 at Hickory Crawdads 6 | Final |
| April 23, 2025 | W | Salem Red Sox 4 at Hickory Crawdads 0 | Final (10) |
| April 24, 2025 | L | Salem Red Sox 0 at Hickory Crawdads 8 | Final |
| April 25, 2025 | L | Salem Red Sox 4 at Hickory Crawdads 6 | Final |
| April 26, 2025 | L | Salem Red Sox 5 at Hickory Crawdads 6 | Final |
| April 27, 2025 | W | Salem Red Sox 19 at Hickory Crawdads 1 | Final |
| April 29, 2025 | L | Fredericksburg Nationals 9 at Salem Red Sox 5 | Final |
| April 30, 2025 | W | Fredericksburg Nationals 2 at Salem Red Sox 4 | Final |
| May 1, 2025 | W | Fredericksburg Nationals 4 at Salem Red Sox 5 | Final |
| May 2, 2025 | W | Fredericksburg Nationals 2 at Salem Red Sox 3 | Final (10) |
| May 3, 2025 | | Fredericksburg Nationals at Salem Red Sox | Ppd. |
| May 4, 2025 | W | Fredericksburg Nationals 6 at Salem Red Sox 9 | Final |
| May 6, 2025 | L | Salem Red Sox 4 at Fayetteville Woodpeckers 5 | Final |
| May 7, 2025 | W | Salem Red Sox 4 at Fayetteville Woodpeckers 3 | Final |
| May 8, 2025 | W | Salem Red Sox 11 at Fayetteville Woodpeckers 9 | Final (10) |
| May 9, 2025 | W | Salem Red Sox 7 at Fayetteville Woodpeckers 2 | Final |
| May 10, 2025 | L | Salem Red Sox 2 at Fayetteville Woodpeckers 9 | Final |
| May 11, 2025 | L | Salem Red Sox 3 at Fayetteville Woodpeckers 4 | Final |
| May 13, 2025 | L | Salem Red Sox 0 at Charleston RiverDogs 5 | Final |
| May 14, 2025 | L | Salem Red Sox 2 at Charleston RiverDogs 4 | Final |
| May 15, 2025 | L | Salem Red Sox 1 at Charleston RiverDogs 2 | Final |
| May 16, 2025 | L | Salem Red Sox 8 at Charleston RiverDogs 10 | Final |
| May 17, 2025 | W | Salem Red Sox 4 at Charleston RiverDogs 2 | Final |
| May 18, 2025 | W | Salem Red Sox 5 at Charleston RiverDogs 3 | Final (10) |
| May 20, 2025 | L | Delmarva Shorebirds 11 at Salem Red Sox 9 | Final (11) |
| May 21, 2025 | L | Delmarva Shorebirds 14 at Salem Red Sox 4 | Final |
| May 22, 2025 | W | Delmarva Shorebirds 3 at Salem Red Sox 10 | Final |
| May 23, 2025 | L | Delmarva Shorebirds 11 at Salem Red Sox 5 | Final (12) |
| May 24, 2025 | W | Delmarva Shorebirds 3 at Salem Red Sox 4 | Final |
| May 25, 2025 | L | Delmarva Shorebirds 7 at Salem Red Sox 5 | Final |
| May 27, 2025 | | Salem Red Sox at Carolina Mudcats | Ppd. |
| May 28, 2025 | W | Salem Red Sox 4 at Carolina Mudcats 0 (Game 1) | Final (7) |
| May 28, 2025 | L | Salem Red Sox 0 at Carolina Mudcats 1 (Game 2) | Final (7) |
| May 29, 2025 | L | Salem Red Sox 4 at Carolina Mudcats 10 | Final |
| May 30, 2025 | L | Salem Red Sox 7 at Carolina Mudcats 8 | Final |
| May 31, 2025 | | Salem Red Sox at Carolina Mudcats | Ppd. |
| June 1, 2025 | L | Salem Red Sox 2 at Carolina Mudcats 4 | Final |
| June 3, 2025 | W | Lynchburg Hillcats 3 at Salem Red Sox 8 | Final |
| June 4, 2025 | L | Lynchburg Hillcats 2 at Salem Red Sox 1 | Final |
| June 5, 2025 | W | Lynchburg Hillcats 6 at Salem Red Sox 7 | Final |
| June 6, 2025 | L | Lynchburg Hillcats 8 at Salem Red Sox 5 | Final |
| June 7, 2025 | L | Lynchburg Hillcats 10 at Salem Red Sox 5 | Final |
| June 8, 2025 | L | Lynchburg Hillcats 6 at Salem Red Sox 5 | Final |
| June 10, 2025 | L | Salem Red Sox 4 at Delmarva Shorebirds 5 | Final |
| June 11, 2025 | W | Salem Red Sox 6 at Delmarva Shorebirds 4 | Final |
| June 12, 2025 | W | Salem Red Sox 3 at Delmarva Shorebirds 2 | Final |
| June 13, 2025 | L | Salem Red Sox 3 at Delmarva Shorebirds 4 | Final (10) |
| June 14, 2025 | L | Salem Red Sox 6 at Delmarva Shorebirds 9 | Final |
| June 15, 2025 | L | Salem Red Sox 4 at Delmarva Shorebirds 5 | Final |
| June 17, 2025 | | Fredericksburg Nationals at Salem Red Sox | Cancelled |
| June 18, 2025 | W | Fredericksburg Nationals 2 at Salem Red Sox 7 (Game 1) | Final (7) |
| June 18, 2025 | W | Fredericksburg Nationals 0 at Salem Red Sox 1 (Game 2) | Final (7) |
| June 19, 2025 | L | Fredericksburg Nationals 5 at Salem Red Sox 3 | Final |
| June 20, 2025 | L | Fredericksburg Nationals 3 at Salem Red Sox 0 | Final |
| June 21, 2025 | W | Fredericksburg Nationals 1 at Salem Red Sox 3 | Final |
| June 22, 2025 | L | Fredericksburg Nationals 6 at Salem Red Sox 3 | Final |
| June 24, 2025 | L | Hickory Crawdads 8 at Salem Red Sox 0 | Final |
| June 25, 2025 | W | Hickory Crawdads 2 at Salem Red Sox 5 | Final |
| June 26, 2025 | L | Hickory Crawdads 7 at Salem Red Sox 2 | Final |
| June 27, 2025 | | Hickory Crawdads at Salem Red Sox | Susp. |
| June 28, 2025 | W | Hickory Crawdads 1 at Salem Red Sox 6 (Game 1) | Final |
| June 28, 2025 | | Hickory Crawdads at Salem Red Sox (Game 2) | Ppd. |
| June 29, 2025 | L | Hickory Crawdads 3 at Salem Red Sox 0 (Game 1) | Final (7) |
| June 29, 2025 | L | Hickory Crawdads 8 at Salem Red Sox 0 (Game 2) | Final (7) |
| July 1, 2025 | W | Salem Red Sox 1 at Lynchburg Hillcats 0 | Final (8) |
| July 2, 2025 | W | Salem Red Sox 5 at Lynchburg Hillcats 2 | Final (10) |
| July 3, 2025 | L | Salem Red Sox 1 at Lynchburg Hillcats 7 | Final |
| July 4, 2025 | L | Salem Red Sox 3 at Lynchburg Hillcats 4 | Final |
| July 5, 2025 | W | Salem Red Sox 7 at Lynchburg Hillcats 5 | Final |
| July 6, 2025 | L | Salem Red Sox 5 at Lynchburg Hillcats 6 | Final (10) |
| July 8, 2025 | L | Salem Red Sox 4 at Augusta GreenJackets 7 | Final |
| July 9, 2025 | | Salem Red Sox at Augusta GreenJackets | Ppd. |
| July 10, 2025 | L | Salem Red Sox 0 at Augusta GreenJackets 2 (Game 1) | Final (7) |
| July 10, 2025 | W | Salem Red Sox 1 at Augusta GreenJackets 0 (Game 2) | Final (8) |
| July 11, 2025 | L | Salem Red Sox 0 at Augusta GreenJackets 2 | Final (7) |
| July 12, 2025 | W | Salem Red Sox 12 at Augusta GreenJackets 2 | Final |
| July 13, 2025 | L | Salem Red Sox 4 at Augusta GreenJackets 5 | Final |
| July 18, 2025 | L | Fayetteville Woodpeckers 6 at Salem Red Sox 4 | Final |
| July 19, 2025 | | Fayetteville Woodpeckers at Salem Red Sox | Susp. |
| July 20, 2025 | W | Fayetteville Woodpeckers 6 at Salem Red Sox 7 (Game 1) | Final (10) |
| July 20, 2025 | W | Fayetteville Woodpeckers 3 at Salem Red Sox 5 (Game 2) | Final (7) |
| July 22, 2025 | L | Charleston RiverDogs 8 at Salem Red Sox 6 | Final |
| July 23, 2025 | L | Charleston RiverDogs 6 at Salem Red Sox 3 | Final |
| July 24, 2025 | L | Charleston RiverDogs 8 at Salem Red Sox 2 | Final |
| July 25, 2025 | W | Charleston RiverDogs 5 at Salem Red Sox 6 | Final |
| July 26, 2025 | L | Charleston RiverDogs 5 at Salem Red Sox 0 | Final |
| July 27, 2025 | L | Charleston RiverDogs 6 at Salem Red Sox 5 | Final |
| July 29, 2025 | W | Salem Red Sox 6 at Lynchburg Hillcats 4 | Final |
| July 30, 2025 | L | Salem Red Sox 1 at Lynchburg Hillcats 2 | Final |
| July 31, 2025 | W | Salem Red Sox 4 at Lynchburg Hillcats 2 | Final |
| August 1, 2025 | W | Salem Red Sox 1 at Lynchburg Hillcats 0 | Final |
| August 2, 2025 | W | Salem Red Sox 6 at Lynchburg Hillcats 3 | Final |
| August 3, 2025 | W | Salem Red Sox 6 at Lynchburg Hillcats 4 | Final |
| August 5, 2025 | W | Kannapolis Cannon Ballers 2 at Salem Red Sox 3 | Final |
| August 6, 2025 | | Kannapolis Cannon Ballers at Salem Red Sox | Ppd. |
| August 7, 2025 | L | Kannapolis Cannon Ballers 6 at Salem Red Sox 3 (Game 1) | Final (7) |
| August 7, 2025 | L | Kannapolis Cannon Ballers 2 at Salem Red Sox 1 (Game 2) | Final (7) |
| August 8, 2025 | L | Kannapolis Cannon Ballers 7 at Salem Red Sox 3 | Final |
| August 9, 2025 | W | Kannapolis Cannon Ballers 4 at Salem Red Sox 6 | Final |
| August 10, 2025 | W | Kannapolis Cannon Ballers 7 at Salem Red Sox 8 | Final |
| August 12, 2025 | L | Salem Red Sox 1 at Fredericksburg Nationals 3 | Final |
| August 13, 2025 | | Salem Red Sox at Fredericksburg Nationals | Susp. |
| August 14, 2025 | W | Salem Red Sox 4 at Fredericksburg Nationals 2 (Game 1) | Final |
| August 14, 2025 | L | Salem Red Sox 2 at Fredericksburg Nationals 6 (Game 2) | Final (7) |
| August 15, 2025 | L | Salem Red Sox 4 at Fredericksburg Nationals 5 | Final |
| August 16, 2025 | W | Salem Red Sox 7 at Fredericksburg Nationals 5 | Final |
| August 17, 2025 | L | Salem Red Sox 9 at Fredericksburg Nationals 10 | Final (10) |
| August 19, 2025 | L | Carolina Mudcats 3 at Salem Red Sox 0 | Final |
| August 20, 2025 | W | Carolina Mudcats 2 at Salem Red Sox 4 | Final |
| August 21, 2025 | | Carolina Mudcats at Salem Red Sox | Susp. |
| August 22, 2025 | W | Carolina Mudcats 1 at Salem Red Sox 3 (Game 1) | Final |
| August 22, 2025 | | Carolina Mudcats at Salem Red Sox (Game 2) | Ppd. |
| August 23, 2025 | W | Carolina Mudcats 0 at Salem Red Sox 2 (Game 1) | Final (7) |
| August 23, 2025 | L | Carolina Mudcats 11 at Salem Red Sox 6 (Game 2) | Final (7) |
| August 24, 2025 | W | Carolina Mudcats 2 at Salem Red Sox 3 | Final |
| August 26, 2025 | L | Salem Red Sox 4 at Kannapolis Cannon Ballers 9 | Final |
| August 27, 2025 | L | Salem Red Sox 1 at Kannapolis Cannon Ballers 5 | Final |
| August 28, 2025 | W | Salem Red Sox 5 at Kannapolis Cannon Ballers 4 | Final |
| August 29, 2025 | L | Salem Red Sox 7 at Kannapolis Cannon Ballers 10 | Final |
| August 30, 2025 | L | Salem Red Sox 6 at Kannapolis Cannon Ballers 9 | Final |
| August 31, 2025 | L | Salem Red Sox 1 at Kannapolis Cannon Ballers 4 | Final |
| September 1, 2025 | W | Fayetteville Woodpeckers 5 at Salem Red Sox 8 | Final |
| September 3, 2025 | L | Fayetteville Woodpeckers 8 at Salem Red Sox 2 | Final |
| September 4, 2025 | W | Fayetteville Woodpeckers 2 at Salem Red Sox 7 | Final |
| September 5, 2025 | L | Fayetteville Woodpeckers 13 at Salem Red Sox 7 | Final |
| September 6, 2025 | W | Fayetteville Woodpeckers 9 at Salem Red Sox 13 | Final |
| September 7, 2025 | W | Fayetteville Woodpeckers 2 at Salem Red Sox 3 | Final |
Salem Red Sox Schedule
