Columbus Lions Schedule
All times Eastern
Complete Schedule
| March 21, 2025 | W | Carolina Cobras 0 at Columbus Lions 25 | Final |
| March 28, 2025 | L | Columbus Lions 20 at Carolina Cobras 40 | Final |
| April 18, 2025 | L | Beaumont Renegades 44 at Columbus Lions 37 | Final |
| April 26, 2025 | L | Columbus Lions 38 at Colorado Spartans 42 | Final |
| May 3, 2025 | Columbus Lions at Carolina Cobras | Cancelled | |
| May 10, 2025 | W | Louisiana Rouxgaroux 20 at Columbus Lions 40 | Final |
| May 17, 2025 | W | Columbus Lions 40 at Beaumont Renegades 37 | Final |
| May 24, 2025 | W | Columbus Lions 39 at Wheeling Miners 13 | Final |
| May 31, 2025 | L | Wheeling Miners 47 at Columbus Lions 44 | Final (OT) |
| June 7, 2025 | L | Columbus Lions 45 at Beaumont Renegades 56 (Playoff) | Final |
