| | | |
| June 6, 2018 | W | Vermont Mountaineers 1 at Sanford Mainers 2 | Final |
| June 7, 2018 | L | Winnipesaukee Muskrats 8 at Sanford Mainers 1 | Final |
| June 8, 2018 | L | Sanford Mainers 4 at Plymouth Pilgrims 6 | Final |
| June 10, 2018 | W | Sanford Mainers 3 at Valley Blue Sox 0 | Final |
| June 11, 2018 | W | Danbury Westerners 3 at Sanford Mainers 4 | Final |
| June 13, 2018 | W | Sanford Mainers 6 at Keene Swamp Bats 4 | Final |
| June 14, 2018 | W | Sanford Mainers 5 at Upper Valley Nighthawks 2 | Final |
| June 15, 2018 | L | North Adams SteepleCats 14 at Sanford Mainers 8 | Final |
| June 16, 2018 | W | Winnipesaukee Muskrats 5 at Sanford Mainers 9 | Final |
| June 18, 2018 | | Valley Blue Sox at Sanford Mainers | Ppd. |
| June 19, 2018 | W | Sanford Mainers 4 at Vermont Mountaineers 3 | Final |
| June 20, 2018 | W | North Adams SteepleCats 3 at Sanford Mainers 4 | Final |
| June 21, 2018 | L | Sanford Mainers 2 at Valley Blue Sox 7 | Final |
| June 22, 2018 | L | Sanford Mainers 4 at New Bedford Bay Sox 6 | Final |
| June 23, 2018 | W | Vermont Mountaineers 2 at Sanford Mainers 6 | Final |
| June 25, 2018 | L | Plymouth Pilgrims 6 at Sanford Mainers 5 | Final |
| June 26, 2018 | L | Sanford Mainers 5 at Danbury Westerners 8 | Final |
| June 27, 2018 | W | Sanford Mainers 1 at Mystic Schooners 0 | Final (11) |
| June 28, 2018 | | Sanford Mainers at Ocean State Waves | Ppd. |
| June 29, 2018 | L | North Adams SteepleCats 11 at Sanford Mainers 7 | Final |
| June 30, 2018 | W | Vermont Mountaineers 3 at Sanford Mainers 5 | Final |
| July 2, 2018 | W | Sanford Mainers 8 at Winnipesaukee Muskrats 1 | Final |
| July 4, 2018 | L | Sanford Mainers 1 at North Adams SteepleCats 4 | Final |
| July 6, 2018 | L | Sanford Mainers 1 at Vermont Mountaineers 5 | Final |
| July 7, 2018 | W | Sanford Mainers 14 at North Adams SteepleCats 7 | Final |
| July 9, 2018 | L | Keene Swamp Bats 5 at Sanford Mainers 3 | Final (10) |
| July 11, 2018 | W | Sanford Mainers 7 at Newport Gulls 1 | Final |
| July 12, 2018 | W | Winnipesaukee Muskrats 4 at Sanford Mainers 9 | Final |
| July 13, 2018 | L | Valley Blue Sox 4 at Sanford Mainers 0 (Game 1) | Final (11) |
| July 13, 2018 | W | Valley Blue Sox 1 at Sanford Mainers 2 (Game 2) | Final (7) |
| July 14, 2018 | | Sanford Mainers at Upper Valley Nighthawks | Ppd. |
| July 15, 2018 | W | Sanford Mainers 7 at North Adams SteepleCats 3 | Final |
| July 16, 2018 | W | Keene Swamp Bats 4 at Sanford Mainers 5 | Final |
| July 18, 2018 | L | Sanford Mainers 2 at Keene Swamp Bats 11 | Final |
| July 19, 2018 | W | Upper Valley Nighthawks 1 at Sanford Mainers 2 | Final |
| July 20, 2018 | W | Valley Blue Sox 1 at Sanford Mainers 2 | Final |
| July 21, 2018 | L | Sanford Mainers 2 at Upper Valley Nighthawks 5 | Final |
| July 23, 2018 | L | Ocean State Waves 4 at Sanford Mainers 0 (Game 1) | Final (7) |
| July 23, 2018 | L | Ocean State Waves 6 at Sanford Mainers 1 (Game 2) | Final (7) |
| July 24, 2018 | L | Upper Valley Nighthawks 5 at Sanford Mainers 2 | Final |
| July 25, 2018 | | Sanford Mainers at Valley Blue Sox | Ppd. |
| July 26, 2018 | | Mystic Schooners at Sanford Mainers | Ppd. |
| July 27, 2018 | W | Sanford Mainers 10 at Winnipesaukee Muskrats 7 | Final |
| July 28, 2018 | | New Bedford Bay Sox at Sanford Mainers | Ppd. |
| July 31, 2018 | W | New Bedford Bay Sox 6 at Sanford Mainers 7 | Final |
| July 31, 2018 | L | Newport Gulls 10 at Sanford Mainers 7 | Final |
| August 1, 2018 | | Sanford Mainers at Valley Blue Sox | Ppd. |
| August 1, 2018 | W | Sanford Mainers 9 at Keene Swamp Bats 2 | Final |
| August 2, 2018 | | Mystic Schooners at Sanford Mainers | Cancelled |
| August 3, 2018 | | Keene Swamp Bats at Sanford Mainers (Playoff) | Ppd. |
| August 4, 2018 | | Keene Swamp Bats at Sanford Mainers (Playoff) | Ppd. |
| August 5, 2018 | W | Keene Swamp Bats 0 at Sanford Mainers 2 (Playoff) | Final |
| August 6, 2018 | L | Sanford Mainers 2 at Valley Blue Sox 4 (Playoff Gm. 1) | Final |
| August 7, 2018 | L | Valley Blue Sox 8 at Sanford Mainers 6 (Playoff Gm. 2) | Final |
Sanford Mainers Schedule
