National Professional Soccer League Schedule
All times Eastern
Complete Schedule
| October 28, 2000 | 20 at Baltimore Spirit 23 | Final | |
| October 28, 2000 | 7 at Buffalo Blizzard 17 | Final | |
| October 29, 2000 | Baltimore Spirit 19 at 26 | Final | |
| October 29, 2000 | Buffalo Blizzard 8 at Edmonton Drillers 16 | Final | |
| November 2, 2000 | 4 at Edmonton Drillers 26 | Final | |
| November 4, 2000 | 16 at Buffalo Blizzard 14 | Final (OT) | |
| November 5, 2000 | Baltimore Spirit 19 at 8 | Final | |
| November 10, 2000 | Buffalo Blizzard 13 at 21 | Final | |
| November 10, 2000 | Edmonton Drillers 17 at Baltimore Spirit 15 | Final | |
| November 11, 2000 | Buffalo Blizzard 6 at 15 | Final | |
| November 11, 2000 | Edmonton Drillers 4 at Milwaukee 20 | Final | |
| November 13, 2000 | Edmonton Drillers 9 at Baltimore Spirit 22 | Final | |
| November 16, 2000 | Milwaukee 8 at Edmonton Drillers 9 | Final | |
| November 17, 2000 | Baltimore Spirit 23 at 6 | Final | |
| November 18, 2000 | 11 at Baltimore Spirit 17 | Final | |
| November 18, 2000 | Milwaukee 10 at Edmonton Drillers 16 | Final | |
| November 19, 2000 | 9 at Buffalo Blizzard 20 | Final | |
| November 22, 2000 | Edmonton Drillers 15 at 19 | Final | |
| November 24, 2000 | Edmonton Drillers 23 at Baltimore Spirit 14 | Final | |
| November 25, 2000 | Baltimore Spirit 4 at 14 | Final | |
| November 25, 2000 | 7 at Buffalo Blizzard 9 | Final (OT) | |
| December 1, 2000 | Milwaukee 9 at Baltimore Spirit 8 | Final | |
| December 2, 2000 | Baltimore Spirit 12 at 20 | Final | |
| December 2, 2000 | Buffalo Blizzard 12 at 14 | Final (OT) | |
| December 8, 2000 | Buffalo Blizzard 16 at 14 | Final (OT) | |
| December 8, 2000 | 13 at Baltimore Spirit 12 | Final | |
| December 9, 2000 | 14 at Buffalo Blizzard 9 | Final | |
| December 14, 2000 | 12 at Baltimore Spirit 16 | Final | |
| December 15, 2000 | 11 at Buffalo Blizzard 13 | Final (OT) | |
| December 16, 2000 | Baltimore Spirit 17 at 13 | Final | |
| December 16, 2000 | Buffalo Blizzard 9 at Milwaukee 13 | Final | |
| December 27, 2000 | 12 at Buffalo Blizzard 20 | Final | |
| December 28, 2000 | Buffalo Blizzard 7 at Baltimore Spirit 24 | Final | |
| December 30, 2000 | 11 at Baltimore Spirit 20 | Final | |
| January 5, 2001 | 19 at Baltimore Spirit 10 | Final | |
| January 6, 2001 | Milwaukee 10 at Buffalo Blizzard 17 | Final | |
| January 7, 2001 | Baltimore Spirit 9 at 7 | Final (OT) | |
| January 12, 2001 | Buffalo Blizzard 6 at 7 (Trenton, NJ) | Final | |
| January 14, 2001 | Buffalo Blizzard 16 at 18 | Final (2OT) | |
| January 20, 2001 | Buffalo Blizzard 13 at 18 | Final | |
| January 21, 2001 | 15 at Buffalo Blizzard 6 | Final | |
| January 21, 2001 | Baltimore Spirit 6 at Milwaukee 17 | Final | |
| January 27, 2001 | 10 at Baltimore Spirit 5 | Final | |
| January 27, 2001 | 11 at Buffalo Blizzard 15 | Final | |
| January 28, 2001 | Buffalo Blizzard 11 at 8 | Final | |
| January 31, 2001 | 18 at Baltimore Spirit 22 | Final | |
| February 2, 2001 | Milwaukee 11 at Baltimore Spirit 6 | Final | |
| February 2, 2001 | 17 at Buffalo Blizzard 23 | Final | |
| February 4, 2001 | 12 at Buffalo Blizzard 9 | Final | |
| February 4, 2001 | Baltimore Spirit 8 at Milwaukee 13 | Final | |
| February 6, 2001 | Buffalo Blizzard 6 at 12 | Final | |
| February 10, 2001 | 5 at Buffalo Blizzard 14 | Final | |
| February 11, 2001 | Baltimore Spirit 12 at 16 | Final | |
| February 17, 2001 | Buffalo Blizzard 13 at 8 | Final | |
| February 18, 2001 | Baltimore Spirit 4 at Milwaukee 13 | Final | |
| February 22, 2001 | Baltimore Spirit 4 at Buffalo Blizzard 19 | Final | |
| February 23, 2001 | Buffalo Blizzard 13 at 11 | Final | |
| February 25, 2001 | Buffalo Blizzard 14 at 19 | Final | |
| February 25, 2001 | Baltimore Spirit 14 at 10 | Final | |
| February 28, 2001 | Baltimore Spirit 9 at 18 | Final | |
| March 2, 2001 | Baltimore Spirit 19 at 16 | Final | |
| March 3, 2001 | Baltimore Spirit 12 at 19 | Final | |
| March 3, 2001 | Buffalo Blizzard 8 at 6 | Final | |
| March 4, 2001 | Buffalo Blizzard 11 at 7 | Final | |
| March 4, 2001 | 11 at Baltimore Spirit 17 | Final | |
| March 8, 2001 | 14 at Buffalo Blizzard 18 | Final | |
| March 9, 2001 | 15 at Baltimore Spirit 13 | Final | |
| March 11, 2001 | 9 at Baltimore Spirit 20 | Final | |
| March 11, 2001 | 13 at Buffalo Blizzard 12 | Final | |
| March 17, 2001 | Baltimore Spirit 8 at 18 | Final | |
| March 17, 2001 | 6 at Buffalo Blizzard 16 | Final | |
| March 22, 2001 | Baltimore Spirit 11 at 10 | Final | |
| March 22, 2001 | 6 at Buffalo Blizzard 12 | Final | |
| March 23, 2001 | Baltimore Spirit 4 at 11 | Final | |
| March 24, 2001 | Buffalo Blizzard 12 at 14 | Final (OT) | |
| March 24, 2001 | Milwaukee 9 at Baltimore Spirit 6 | Final | |
| March 29, 2001 | 12 at Baltimore Spirit 13 | Final | |
| March 29, 2001 | 15 at Buffalo Blizzard 18 | Final | |
| March 31, 2001 | Buffalo Blizzard 16 at 8 | Final | |
| March 31, 2001 | 13 at Baltimore Spirit 19 | Final | |
| April 1, 2001 | 9 at Buffalo Blizzard 12 | Final | |
| April 6, 2001 | Baltimore Spirit 8 at 14 (Playoff Game 1) | Final | |
| April 7, 2001 | 7 at Baltimore Spirit 17 (Playoff Game 2) | Final | |
| April 7, 2001 | 9 at Buffalo Blizzard 8 (Playoff Game 1) | Final | |
| April 13, 2001 | Buffalo Blizzard 13 at 18 (Playoff Game 2) | Final | |
| April 13, 2001 | Baltimore Spirit 12 at 16 (Playoff Game 3) | Final |
