| | | |
| April 4, 2025 | L | Myrtle Beach Pelicans 13 at Charleston RiverDogs 2 | Final |
| April 5, 2025 | L | Myrtle Beach Pelicans 4 at Charleston RiverDogs 3 | Final |
| April 6, 2025 | L | Myrtle Beach Pelicans 5 at Charleston RiverDogs 2 | Final |
| April 8, 2025 | L | Charleston RiverDogs 1 at Columbia Fireflies 4 | Final |
| April 9, 2025 | L | Charleston RiverDogs 3 at Columbia Fireflies 8 | Final |
| April 10, 2025 | L | Charleston RiverDogs 2 at Columbia Fireflies 5 | Final |
| April 11, 2025 | W | Charleston RiverDogs 7 at Columbia Fireflies 3 | Final |
| April 12, 2025 | W | Charleston RiverDogs 10 at Columbia Fireflies 1 | Final |
| April 13, 2025 | L | Charleston RiverDogs 3 at Columbia Fireflies 9 | Final |
| April 15, 2025 | W | Hickory Crawdads 2 at Charleston RiverDogs 3 | Final |
| April 16, 2025 | L | Hickory Crawdads 10 at Charleston RiverDogs 3 | Final |
| April 17, 2025 | W | Hickory Crawdads 1 at Charleston RiverDogs 6 | Final |
| April 18, 2025 | W | Hickory Crawdads 0 at Charleston RiverDogs 1 | Final |
| April 19, 2025 | W | Hickory Crawdads 0 at Charleston RiverDogs 3 | Final |
| April 20, 2025 | L | Hickory Crawdads 7 at Charleston RiverDogs 5 | Final |
| April 22, 2025 | L | Charleston RiverDogs 2 at Fredericksburg Nationals 4 | Final |
| April 23, 2025 | W | Charleston RiverDogs 6 at Fredericksburg Nationals 2 | Final |
| April 24, 2025 | W | Charleston RiverDogs 6 at Fredericksburg Nationals 0 | Final |
| April 25, 2025 | L | Charleston RiverDogs 1 at Fredericksburg Nationals 8 | Final |
| April 26, 2025 | L | Charleston RiverDogs 3 at Fredericksburg Nationals 5 | Final |
| April 27, 2025 | L | Charleston RiverDogs 5 at Fredericksburg Nationals 6 | Final (10) |
| April 29, 2025 | L | Charleston RiverDogs 5 at Lynchburg Hillcats 6 | Final |
| April 30, 2025 | L | Charleston RiverDogs 4 at Lynchburg Hillcats 7 | Final |
| May 1, 2025 | L | Charleston RiverDogs 2 at Lynchburg Hillcats 8 | Final |
| May 2, 2025 | L | Charleston RiverDogs 0 at Lynchburg Hillcats 6 | Final |
| May 3, 2025 | | Charleston RiverDogs at Lynchburg Hillcats | Ppd. |
| May 4, 2025 | W | Charleston RiverDogs 3 at Lynchburg Hillcats 1 (Game 1) | Final (7) |
| May 4, 2025 | W | Charleston RiverDogs 7 at Lynchburg Hillcats 1 (Game 2) | Final (7) |
| May 6, 2025 | W | Columbia Fireflies 0 at Charleston RiverDogs 4 | Final |
| May 7, 2025 | W | Columbia Fireflies 2 at Charleston RiverDogs 3 | Final |
| May 8, 2025 | W | Columbia Fireflies 1 at Charleston RiverDogs 5 | Final |
| May 9, 2025 | L | Columbia Fireflies 3 at Charleston RiverDogs 2 | Final |
| May 10, 2025 | W | Columbia Fireflies 6 at Charleston RiverDogs 10 | Final |
| May 11, 2025 | W | Columbia Fireflies 2 at Charleston RiverDogs 3 | Final |
| May 13, 2025 | W | Salem Red Sox 0 at Charleston RiverDogs 5 | Final |
| May 14, 2025 | W | Salem Red Sox 2 at Charleston RiverDogs 4 | Final |
| May 15, 2025 | W | Salem Red Sox 1 at Charleston RiverDogs 2 | Final |
| May 16, 2025 | W | Salem Red Sox 8 at Charleston RiverDogs 10 | Final |
| May 17, 2025 | L | Salem Red Sox 4 at Charleston RiverDogs 2 | Final |
| May 18, 2025 | L | Salem Red Sox 5 at Charleston RiverDogs 3 | Final (10) |
| May 20, 2025 | L | Charleston RiverDogs 4 at Augusta GreenJackets 6 | Final |
| May 21, 2025 | L | Charleston RiverDogs 4 at Augusta GreenJackets 5 | Final |
| May 22, 2025 | L | Charleston RiverDogs 2 at Augusta GreenJackets 5 | Final |
| May 23, 2025 | L | Charleston RiverDogs 11 at Augusta GreenJackets 13 | Final |
| May 24, 2025 | L | Charleston RiverDogs 5 at Augusta GreenJackets 6 | Final |
| May 25, 2025 | W | Charleston RiverDogs 10 at Augusta GreenJackets 8 | Final |
| May 27, 2025 | L | Kannapolis Cannon Ballers 3 at Charleston RiverDogs 0 | Final |
| May 28, 2025 | W | Kannapolis Cannon Ballers 4 at Charleston RiverDogs 7 | Final |
| May 29, 2025 | | Kannapolis Cannon Ballers at Charleston RiverDogs | Ppd. |
| May 30, 2025 | L | Kannapolis Cannon Ballers 2 at Charleston RiverDogs 1 | Final |
| May 31, 2025 | W | Kannapolis Cannon Ballers 1 at Charleston RiverDogs 5 (Game 1) | Final (7) |
| May 31, 2025 | W | Kannapolis Cannon Ballers 3 at Charleston RiverDogs 5 (Game 2) | Final (7) |
| June 1, 2025 | W | Kannapolis Cannon Ballers 4 at Charleston RiverDogs 5 | Final |
| June 3, 2025 | L | Charleston RiverDogs 0 at Carolina Mudcats 10 | Final |
| June 4, 2025 | W | Charleston RiverDogs 8 at Carolina Mudcats 5 | Final (13) |
| June 5, 2025 | | Charleston RiverDogs at Carolina Mudcats | Ppd. |
| June 6, 2025 | W | Charleston RiverDogs 8 at Carolina Mudcats 4 (Game 1) | Final (7) |
| June 6, 2025 | W | Charleston RiverDogs 3 at Carolina Mudcats 0 (Game 2) | Final (7) |
| June 7, 2025 | W | Charleston RiverDogs 5 at Carolina Mudcats 2 | Final |
| June 8, 2025 | L | Charleston RiverDogs 2 at Carolina Mudcats 6 | Final |
| June 10, 2025 | L | Augusta GreenJackets 5 at Charleston RiverDogs 1 | Final |
| June 11, 2025 | W | Augusta GreenJackets 3 at Charleston RiverDogs 7 | Final |
| June 12, 2025 | W | Augusta GreenJackets 4 at Charleston RiverDogs 5 | Final |
| June 13, 2025 | W | Augusta GreenJackets 1 at Charleston RiverDogs 5 | Final |
| June 14, 2025 | | Augusta GreenJackets at Charleston RiverDogs | Ppd. |
| June 15, 2025 | W | Augusta GreenJackets 4 at Charleston RiverDogs 7 (Game 1) | Final (7) |
| June 15, 2025 | L | Augusta GreenJackets 9 at Charleston RiverDogs 6 (Game 2) | Final (7) |
| June 17, 2025 | W | Charleston RiverDogs 14 at Kannapolis Cannon Ballers 8 | Final |
| June 18, 2025 | W | Charleston RiverDogs 14 at Kannapolis Cannon Ballers 5 | Final |
| June 19, 2025 | W | Charleston RiverDogs 5 at Kannapolis Cannon Ballers 1 | Final |
| June 20, 2025 | W | Charleston RiverDogs 6 at Kannapolis Cannon Ballers 4 | Final |
| June 21, 2025 | W | Charleston RiverDogs 6 at Kannapolis Cannon Ballers 4 | Final (10) |
| June 22, 2025 | W | Charleston RiverDogs 6 at Kannapolis Cannon Ballers 5 | Final |
| June 24, 2025 | L | Lynchburg Hillcats 6 at Charleston RiverDogs 4 | Final |
| June 25, 2025 | W | Lynchburg Hillcats 0 at Charleston RiverDogs 7 | Final (8) |
| June 26, 2025 | L | Lynchburg Hillcats 3 at Charleston RiverDogs 2 | Final |
| June 27, 2025 | L | Lynchburg Hillcats 8 at Charleston RiverDogs 5 | Final |
| June 28, 2025 | W | Lynchburg Hillcats 3 at Charleston RiverDogs 7 | Final |
| June 29, 2025 | W | Lynchburg Hillcats 1 at Charleston RiverDogs 3 | Final |
| July 1, 2025 | L | Myrtle Beach Pelicans 2 at Charleston RiverDogs 1 | Final |
| July 2, 2025 | L | Myrtle Beach Pelicans 10 at Charleston RiverDogs 0 | Final |
| July 3, 2025 | L | Myrtle Beach Pelicans 3 at Charleston RiverDogs 1 | Final |
| July 4, 2025 | L | Charleston RiverDogs 6 at Myrtle Beach Pelicans 8 | Final |
| July 5, 2025 | | Charleston RiverDogs at Myrtle Beach Pelicans | Ppd. |
| July 6, 2025 | W | Charleston RiverDogs 7 at Myrtle Beach Pelicans 1 | Final |
| July 8, 2025 | L | Columbia Fireflies 4 at Charleston RiverDogs 1 | Final |
| July 9, 2025 | W | Columbia Fireflies 4 at Charleston RiverDogs 5 | Final (11) |
| July 10, 2025 | | Columbia Fireflies at Charleston RiverDogs | Ppd. |
| July 11, 2025 | | Columbia Fireflies at Charleston RiverDogs | Susp. |
| July 12, 2025 | W | Columbia Fireflies 2 at Charleston RiverDogs 3 (Game 1) | Final (10) |
| July 12, 2025 | L | Columbia Fireflies 3 at Charleston RiverDogs 2 (Game 2) | Final (7) |
| July 13, 2025 | W | Columbia Fireflies 0 at Charleston RiverDogs 3 | Final |
| July 18, 2025 | W | Charleston RiverDogs 7 at Hickory Crawdads 1 | Final |
| July 19, 2025 | W | Charleston RiverDogs 6 at Hickory Crawdads 4 | Final (10) |
| July 20, 2025 | L | Charleston RiverDogs 5 at Hickory Crawdads 7 | Final |
| July 22, 2025 | W | Charleston RiverDogs 8 at Salem Red Sox 6 | Final |
| July 23, 2025 | W | Charleston RiverDogs 6 at Salem Red Sox 3 | Final |
| July 24, 2025 | W | Charleston RiverDogs 8 at Salem Red Sox 2 | Final |
| July 25, 2025 | L | Charleston RiverDogs 5 at Salem Red Sox 6 | Final |
| July 26, 2025 | W | Charleston RiverDogs 5 at Salem Red Sox 0 | Final |
| July 27, 2025 | W | Charleston RiverDogs 6 at Salem Red Sox 5 | Final |
| July 29, 2025 | W | Myrtle Beach Pelicans 2 at Charleston RiverDogs 4 | Final |
| July 30, 2025 | W | Myrtle Beach Pelicans 3 at Charleston RiverDogs 4 | Final |
| July 31, 2025 | L | Myrtle Beach Pelicans 3 at Charleston RiverDogs 0 | Final |
| August 1, 2025 | L | Myrtle Beach Pelicans 5 at Charleston RiverDogs 1 | Final |
| August 2, 2025 | L | Myrtle Beach Pelicans 19 at Charleston RiverDogs 1 | Final |
| August 3, 2025 | L | Myrtle Beach Pelicans 9 at Charleston RiverDogs 1 | Final |
| August 5, 2025 | W | Charleston RiverDogs 7 at Augusta GreenJackets 0 | Final |
| August 6, 2025 | L | Charleston RiverDogs 2 at Augusta GreenJackets 14 | Final |
| August 7, 2025 | W | Charleston RiverDogs 3 at Augusta GreenJackets 2 | Final |
| August 8, 2025 | L | Charleston RiverDogs 3 at Augusta GreenJackets 4 | Final |
| August 9, 2025 | L | Charleston RiverDogs 2 at Augusta GreenJackets 11 | Final |
| August 10, 2025 | | Charleston RiverDogs at Augusta GreenJackets | Ppd. |
| August 12, 2025 | L | Hickory Crawdads 6 at Charleston RiverDogs 0 | Final |
| August 13, 2025 | W | Hickory Crawdads 2 at Charleston RiverDogs 3 | Final |
| August 14, 2025 | W | Hickory Crawdads 1 at Charleston RiverDogs 2 | Final (10) |
| August 15, 2025 | W | Hickory Crawdads 3 at Charleston RiverDogs 4 | Final |
| August 16, 2025 | W | Hickory Crawdads 0 at Charleston RiverDogs 7 | Final |
| August 17, 2025 | W | Hickory Crawdads 2 at Charleston RiverDogs 5 | Final |
| August 19, 2025 | L | Charleston RiverDogs 2 at Myrtle Beach Pelicans 8 | Final |
| August 20, 2025 | L | Charleston RiverDogs 7 at Myrtle Beach Pelicans 8 | Final (11) |
| August 21, 2025 | L | Charleston RiverDogs 0 at Myrtle Beach Pelicans 7 | Final |
| August 22, 2025 | W | Charleston RiverDogs 3 at Myrtle Beach Pelicans 2 | Final |
| August 23, 2025 | L | Charleston RiverDogs 4 at Myrtle Beach Pelicans 6 (Game 1) | Final (7) |
| August 23, 2025 | L | Charleston RiverDogs 1 at Myrtle Beach Pelicans 8 (Game 2) | Final (7) |
| August 24, 2025 | L | Charleston RiverDogs 12 at Myrtle Beach Pelicans 13 | Final (11) |
| August 26, 2025 | W | Augusta GreenJackets 4 at Charleston RiverDogs 6 | Final |
| August 27, 2025 | W | Augusta GreenJackets 0 at Charleston RiverDogs 1 (Game 1) | Final (7) |
| August 27, 2025 | W | Charleston RiverDogs 6 at Augusta GreenJackets 4 (Game 2) | Final (7) |
| August 28, 2025 | W | Augusta GreenJackets 1 at Charleston RiverDogs 6 | Final |
| August 29, 2025 | L | Augusta GreenJackets 4 at Charleston RiverDogs 1 | Final |
| August 30, 2025 | L | Augusta GreenJackets 9 at Charleston RiverDogs 8 | Final |
| August 31, 2025 | L | Augusta GreenJackets 12 at Charleston RiverDogs 7 | Final |
| September 2, 2025 | L | Charleston RiverDogs 2 at Hickory Crawdads 3 | Final |
| September 3, 2025 | L | Charleston RiverDogs 3 at Hickory Crawdads 6 | Final |
| September 4, 2025 | | Charleston RiverDogs at Hickory Crawdads | Cancelled |
| September 5, 2025 | L | Charleston RiverDogs 6 at Hickory Crawdads 8 | Final |
| September 6, 2025 | W | Charleston RiverDogs 2 at Hickory Crawdads 1 | Final |
| September 7, 2025 | W | Charleston RiverDogs 12 at Hickory Crawdads 8 | Final |
Charleston RiverDogs Schedule
