London Lightning Schedule
All times Eastern
Complete Schedule
| February 21, 2022 | W | London Lightning 110 at KW Titans 108 | Final |
| February 26, 2022 | W | London Lightning 115 at Windsor Express 92 | Final |
| March 5, 2022 | W | KW Titans 90 at London Lightning 104 | Final |
| March 6, 2022 | W | Lansing Pharoahs 90 at London Lightning 104 | Final |
| March 9, 2022 | W | KW Titans 93 at London Lightning 111 | Final |
| March 12, 2022 | W | Sudbury Five 92 at London Lightning 117 | Final |
| March 13, 2022 | W | Windsor Express 104 at London Lightning 123 | Final |
| March 17, 2022 | W | London Lightning 114 at Sudbury Five 101 | Final |
| March 19, 2022 | W | Syracuse Stallions 95 at London Lightning 109 | Final |
| March 24, 2022 | W | Sudbury Five 105 at London Lightning 108 | Final |
| March 27, 2022 | W | Windsor Express 103 at London Lightning 110 | Final |
| March 31, 2022 | L | London Lightning 90 at Albany Patroons 97 | Final |
| April 2, 2022 | L | London Lightning 102 at KW Titans 103 | Final |
| April 3, 2022 | W | Flint United 83 at London Lightning 113 | Final |
| April 6, 2022 | W | KW Titans 82 at London Lightning 107 | Final |
| April 9, 2022 | W | London Lightning 112 at Lansing Pharoahs 94 | Final |
| April 10, 2022 | W | London Lightning 95 at Flint United 88 | Final |
| April 14, 2022 | L | London Lightning 110 at Sudbury Five 118 | Final |
| April 22, 2022 | L | London Lightning 92 at Windsor Express 110 | Final |
| April 23, 2022 | W | London Lightning 106 at KW Titans 103 | Final |
| May 1, 2022 | W | London Lightning 113 at Windsor Express 99 | Final |
| May 2, 2022 | W | Windsor Express 96 at London Lightning 105 | Final |
| May 9, 2022 | W | London Lightning 120 at Sudbury Five 104 | Final |
| May 12, 2022 | W | Sudbury Five 115 at London Lightning 125 | Final |
| May 15, 2022 | W | Windsor Express 99 at London Lightning 106 (Playoff Gm. 1) | Final |
| May 17, 2022 | W | Windsor Express 97 at London Lightning 107 (Playoff Gm. 2) | Final |
| May 20, 2022 | W | London Lightning 110 at Windsor Express 108 (Playoff Gm. 3) | Final |
| May 27, 2022 | W | KW Titans 91 at London Lightning 116 (Champ. Gm. 1) | Final |
| May 29, 2022 | W | KW Titans 110 at London Lightning 115 (Champ. Gm. 2) | Final |
| June 1, 2022 | W | London Lightning 97 at KW Titans 96 (Champ. Gm. 3) | Final |
