Columbus Destroyers Schedule
All times Eastern
Complete Schedule
| March 2, 2008 | L | Columbus Destroyers 47 at Colorado Crush 50 | Final |
| March 7, 2008 | L | Columbus Destroyers 36 at Dallas Desperados 46 | Final |
| March 21, 2008 | W | Columbus Destroyers 52 at Utah Blaze 49 | Final |
| April 13, 2008 | L | Columbus Destroyers 44 at New York Dragons 62 | Final |
| April 21, 2008 | L | Philadelphia Soul 76 at Columbus Destroyers 55 | Final |
| May 3, 2008 | L | Dallas Desperados 48 at Columbus Destroyers 45 | Final |
| May 10, 2008 | L | Columbus Destroyers 43 at Kansas City Brigade 59 | Final |
| May 17, 2008 | L | Columbus Destroyers 43 at Philadelphia Soul 51 | Final |
| May 24, 2008 | W | New York Dragons 41 at Columbus Destroyers 43 | Final |
| May 30, 2008 | L | Columbus Destroyers 61 at New Orleans VooDoo 83 | Final |
| June 7, 2008 | L | Georgia Force 63 at Columbus Destroyers 34 | Final |
| June 14, 2008 | L | Grand Rapids Rampage 63 at Columbus Destroyers 60 | Final |
