| | | |
| March 30, 2022 | W | Earthquakes II 2 at Portland Timbers 2 0 | Final |
| April 3, 2022 | L | Earthquakes II 0 at Houston Dynamo 2 1 | Final |
| April 17, 2022 | L | North Texas SC 1 at Earthquakes II 0 | Final |
| April 25, 2022 | T | Tacoma Defiance 2 at Earthquakes II 2 | Final (PK 5-4) |
| April 30, 2022 | L | Earthquakes II 0 at Vancouver Whitecaps FC 2 2 | Final |
| May 8, 2022 | W | Portland Timbers 2 0 at Earthquakes II 3 | Final |
| May 15, 2022 | W | Colorado Rapids 2 1 at Earthquakes II 7 | Final |
| May 20, 2022 | L | Sporting Kansas City II 2 at Earthquakes II 1 | Final |
| May 29, 2022 | | Earthquakes II at St. Louis City SC 2 | 8:00 p.m. |
| June 4, 2022 | | Earthquakes II at Tacoma Defiance | 10:00 p.m. |
| June 8, 2022 | | Minnesota United FC 2 at Earthquakes II | 10:00 p.m. |
| June 17, 2022 | | Earthquakes II at Real Monarchs | 9:00 p.m. |
| June 24, 2022 | | Earthquakes II at Vancouver Whitecaps FC 2 | 10:00 p.m. |
| July 1, 2022 | | Houston Dynamo 2 at Earthquakes II | 10:30 p.m. |
| July 10, 2022 | | Earthquakes II at North Texas SC | 8:30 p.m. |
| July 15, 2022 | | Earthquakes II at Colorado Rapids 2 | 6:00 p.m. |
| July 22, 2022 | | Earthquakes II at Portland Timbers 2 | 10:00 p.m. |
| July 31, 2022 | | Real Monarchs at Earthquakes II | 9:00 p.m. |
| August 5, 2022 | | Tacoma Defiance at Earthquakes II | 10:30 p.m. |
| August 21, 2022 | | St. Louis City SC 2 at Earthquakes II | 10:00 p.m. |
| August 28, 2022 | | Earthquakes II at Sporting Kansas City II | 6:00 p.m. |
| September 5, 2022 | | Vancouver Whitecaps FC 2 at Earthquakes II | 9:00 p.m. |
| September 9, 2022 | | Real Monarchs at Earthquakes II | 9:00 p.m. |
| September 18, 2022 | | Earthquakes II at Minnesota United FC 2 | 7:00 p.m. |
Earthquakes II Schedule
