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| March 27, 2022 | T | Sporting Kansas City II 1 at Colorado Rapids 2 1 | Final (PK 2-4) |
| April 10, 2022 | L | Colorado Rapids 2 1 at North Texas SC 3 | Final |
| April 17, 2022 | L | Colorado Rapids 2 0 at Minnesota United FC 2 4 | Final |
| May 1, 2022 | W | Portland Timbers 2 1 at Colorado Rapids 2 3 | Final |
| May 8, 2022 | L | Colorado Rapids 2 0 at Houston Dynamo 2 2 | Final |
| May 15, 2022 | L | Colorado Rapids 2 1 at Earthquakes II 7 | Final |
| May 22, 2022 | | Tacoma Defiance at Colorado Rapids 2 | 11:00 p.m. |
| May 29, 2022 | | Colorado Rapids 2 at Minnesota United FC 2 | 2:00 p.m. |
| June 4, 2022 | | North Texas SC at Colorado Rapids 2 | 9:00 p.m. |
| June 8, 2022 | | St. Louis City SC 2 at Colorado Rapids 2 | 9:00 p.m. |
| June 12, 2022 | | Real Monarchs at Colorado Rapids 2 | 9:00 p.m. |
| June 18, 2022 | | Colorado Rapids 2 at Tacoma Defiance | 10:00 p.m. |
| June 26, 2022 | | Colorado Rapids 2 at Portland Timbers 2 | 10:00 p.m. |
| July 2, 2022 | | Colorado Rapids 2 at St. Louis City SC 2 | 8:00 p.m. |
| July 10, 2022 | | Sporting Kansas City II at Colorado Rapids 2 | 8:00 p.m. |
| July 15, 2022 | | Earthquakes II at Colorado Rapids 2 | 6:00 p.m. |
| July 24, 2022 | | Vancouver Whitecaps FC 2 at Colorado Rapids 2 | 8:00 p.m. |
| August 6, 2022 | | Minnesota United FC 2 at Colorado Rapids 2 | 12:00 a.m. |
| August 14, 2022 | | Colorado Rapids 2 at Houston Dynamo 2 | 9:00 p.m. |
| August 21, 2022 | | North Texas SC at Colorado Rapids 2 | 10:00 p.m. |
| August 25, 2022 | | Colorado Rapids 2 at Vancouver Whitecaps FC 2 | 10:00 p.m. |
| September 5, 2022 | | Colorado Rapids 2 at Sporting Kansas City II | 8:00 p.m. |
| September 11, 2022 | | Houston Dynamo 2 at Colorado Rapids 2 | 8:00 p.m. |
| September 18, 2022 | | Colorado Rapids 2 at Real Monarchs | 7:00 p.m. |
Colorado Rapids 2 Schedule
