| | | |
| March 27, 2022 | T | New England Revolution II 2 at New York City FC II 2 | Final (PK 4-3) |
| April 3, 2022 | T | New York City FC II 2 at Orlando City B 2 | Final (PK 3-4) |
| April 10, 2022 | L | New York City FC II 1 at Toronto FC II 3 | Final |
| April 16, 2022 | W | Inter Miami CF II 0 at New York City FC II 7 | Final |
| April 23, 2022 | W | New York City FC II 3 at Rochester New York FC 2 | Final |
| April 30, 2022 | L | New York City FC II 1 at Philadelphia Union II 2 | Final |
| May 8, 2022 | W | Toronto FC II 1 at New York City FC II 4 | Final |
| May 15, 2022 | L | Columbus Crew 2 1 at New York City FC II 0 | Final |
| May 21, 2022 | W | Chicago Fire FC II 0 at New York City FC II 3 | Final |
| May 29, 2022 | | New York City FC II at Inter Miami CF II | 7:00 p.m. |
| June 4, 2022 | | New York City FC II at Orlando City B | 7:00 p.m. |
| June 18, 2022 | | Toronto FC II at New York City FC II | 1:00 p.m. |
| June 27, 2022 | | New York City FC II at Philadelphia Union II | 7:00 p.m. |
| July 2, 2022 | | FC Cincinnati 2 at New York City FC II | 7:00 p.m. |
| July 10, 2022 | | New York City FC II at New England Revolution II | 6:00 p.m. |
| July 16, 2022 | | Rochester New York FC at New York City FC II | 7:00 p.m. |
| July 24, 2022 | | Inter Miami CF II at New York City FC II | 6:00 p.m. |
| August 7, 2022 | | New York City FC II at Columbus Crew 2 | 5:00 p.m. |
| August 12, 2022 | | Orlando City B at New York City FC II | 8:00 p.m. |
| August 20, 2022 | | New York City FC II at Chicago Fire FC II | 8:00 p.m. |
| August 24, 2022 | | Philadelphia Union II at New York City FC II | 6:00 p.m. |
| September 4, 2022 | | New York City FC II at FC Cincinnati 2 | 4:00 p.m. |
| September 10, 2022 | | New England Revolution II at New York City FC II | 8:00 p.m. |
| September 18, 2022 | | New York City FC II at Rochester New York FC | 3:00 p.m. |
New York City FC II Schedule
